Results 71 to 80 of about 805,988 (244)

Reaction of Furanoeremophilans with Pyridoxal

Natural Product Communications, 2008
Furanoeremophilan-10β-ol, a major component of Ligularia cymbulifera growing in northwestern Yunnan Province of China, reacted with pyridoxal or its 5′-phosphate at room temperature in aqueous solution to afford condensation products.
Atsushi Torihata, Chiaki Kuroda
doaj   +1 more source

Nuclear‐Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra‐High Field

Journal of the Chinese Chemical Society, EarlyView.
This study shows that the sensitivity of liquid‐state NMR spectroscopy can be dramatically increased, with enhancement factors up to 160‐fold on a 1.1 GHz ultra‐high‐field NMR spectrometer. This advance exploits low‐concentration photochemically induced dynamic nuclear polarization (LC‐photo‐CIDNP) and it enables facile atomic‐resolution detection of ...
Ji Ho Jeong, Anubhab Halder, Silvia Cavagnero   +2 more
wiley   +1 more source

Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists

eLife
P2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng, Chen-Xi Yue, Fei Jin, Yao Wang, Muneyoshi Ichikawa, Ye Yu, Chang-Run Guo, Motoyuki Hattori   +7 more
doaj   +1 more source

Modification of Pepsinogen with Pyridoxal Phosphate

Journal of Biological Chemistry, 1974
Pyridoxal-PO4 binds to pepsinogen in a reaction in which the stoichiometry is highly dependent on the conformation of the protein. When pepsinogen is in its native conformation, pyridoxal-PO4 forms Schiff bases with the α-NH2 group of Leu1 and the e-NH2 group of Lys358.
openaire   +2 more sources

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Methods Stool was collected from 120 subjects (AP [n = 30], CD
Neha R. Santucci, Chinenye R. Dike, Jenny Hellmann, Nicholas J. Ollberding, Qing Duan, Philip Minar, Lee A. Denson, David B. Haslam, Daniel Castillo, Maisam Abu‐El‐Haija   +9 more
wiley   +1 more source

Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider, Claudia Hanko, Konrad Büssow, Stefan Schmelz, Wulf Blankenfeldt   +4 more
wiley   +1 more source

Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways

Yeast, EarlyView.
ABSTRACT The genus Nakaseomyces provides four species that are closely related but have different characteristics. For example, N. glabratus (formerly known as Candida glabrata) is a common human pathogen, whereas N. bracarensis and N. nivariensis have been isolated in clinical settings but are not common human pathogens. N.
Maria Abraham, Christine L. Iosue, Dennis D. Wykoff   +2 more
wiley   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy

Pharmaceuticals
Background/Objectives: Septic cardiomyopathy (SCM) is a severe cardiac complication of sepsis, characterized by cardiac dysfunction with limited effective treatments.
Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban   +8 more
doaj   +1 more source

Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous oxalosis is an uncommon manifestation of primary hyperoxalosis, which can often resemble other cutaneous manifestations of end stage renal disease (ESRD), particularly calciphylaxis. We report the case of a 46 year old female with primary hyperoxaluria type one (PH1) believed to be well‐controlled on lumasiran, a small interfering ...
Shrina Patel, Brad Graham, Kaci Reaves, Mya Phelps   +3 more
wiley   +1 more source