Results 61 to 70 of about 5,110,049 (220)

Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder.

PLoS ONE, 2021
Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD).
Zarazuela Zolkipli-Cunningham, Jane C Naviaux, Tomohiro Nakayama, Charlotte M Hirsch, Jonathan M Monk, Kefeng Li, Lin Wang, Thuy P Le, Simone Meinardi, Donald R Blake, Robert K Naviaux   +10 more
doaj   +1 more source

Icariin Alleviates Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice by Modulating the Gut–Lung Axis and Serum Metabolism

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of uncertain etiology with few specific and effective therapeutic agents approved for its treatment. We examined the underlying processes and the impact of icariin (ICA) on a bleomycin‐induced pulmonary fibrosis model.
Ting Zhang, Weiyi Gong, Cheng Huang, Hongkai Wang, Baojun Liu, Dawei Cui   +5 more
wiley   +1 more source

The vitamin B6 requirement in oral contraceptive users II. Assessment by tryptophan metabolites, vitamin B6, and pyridoxic acid levels in urine

American Journal of Clinical Nutrition, 1979
Elizabeth A. Donald, TR Bossé
openalex   +2 more sources

Periodontitis Salivary Microbiota Exacerbates Murine Rheumatoid Arthritis via Gut Dysbiosis and Immune Dysregulation

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
Salivary multiomics from healthy, PD, RA, and PD‐RA cohorts identified PD−/RA‐linked microbial and metabolic signatures. We then transplanted salivary microbiota from a PD donor or a healthy donor into collagen‐induced arthritis mice. PD microbiota colonized the gut, reshaped communities, weakened epithelial tight junctions, and provoked systemic ...
Ruiyang Ge, Rong Liu, Yingying Zhou, Ziyao Zhuang, Haowei Mao, Wenzheng Liao, Lei Han, Wenrong Yang, Fuhua Yan, Di Cui   +9 more
wiley   +1 more source

Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate (GCDCA‐S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1532-1542, December 2025.
Endogenous biomarkers for drug transporters are an emerging tool for the assessment of transporter‐mediated drug–drug interactions (DDI). Glycochenodeoxycholic acid 3‐O‐sulfate (GCDCA‐S) has been proposed as a Tier 2 biomarker of hepatic OATP1B3 and renal OAT3 transporters by the International Transporter Consortium.
Yuki Ujihira, Viktor Georgiev, Kayode Ogungbenro, Aleksandra Galetin   +3 more
wiley   +1 more source

A Novel Two-Dimensional Liquid Chromatography Combined with Ultraviolet Detection Method for Quantitative Determination of Pyridoxal 5′-Phosphate, 4-Pyridoxine Acid and Pyridoxal in Animal Plasma

Animals, 2023
Vitamin B6 is an indispensable micronutrient in organisms and is widely distributed in blood, tissues, and organs. Changes in the content and ratio of vitamin B6 can affect the entire physiological condition of the body, so it becomes particularly ...
Rong-Ju Yang, Na Wang, Xiao Ma, Meng-Die Gong, Yi-Rong Wang, Si-Yu Meng, Zhao-Ying Liu, Qi Tang   +7 more
doaj   +1 more source

Integration of Bioinformatics, Serum Pharmacochemistry, and Metabolomics to Reveal the Mechanisms of Danggui Buxue Decoction in Anti‐Rheumatoid Arthritis Through Inflammation and NF‐κB Signaling Pathway Regulation

Immunity, Inflammation and Disease, Volume 13, Issue 9, September 2025.
ABSTRACT Objective Rheumatoid arthritis (RA) remains a significant clinical challenge due to the limited efficacy and adverse effects associated with conventional treatments. Danggui buxue decoction (DBD), renowned for its qi‐tonifying, blood‐nourishing, and anti‐inflammatory properties, has shown promising potential in the management of RA. This study
Lianyun Du, Ye Zhai, Meixiu Luo, Lu Tang, Saiyue Qiu, Xin Jiang, Enpeng Wang, Zhi Pan   +7 more
wiley   +1 more source

Genetic mutation and aqueous humor metabolites alterations in a family with Marfan syndrome

Heliyon
This study used four generations of a Chinese family to reveal the genetic etiology and ocular manifestation pathogenesis of Marfan syndrome (MFS) through whole genome sequencing (WGS) and metabolomics analysis.
Jing Wu, Fei Li, Jingjing Zhang, Xiao-dan Hao   +3 more
doaj   +1 more source

Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats

Journal of Nutritional Science, 2013
We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating ...
Katsumi Shibata, Chisa Sugita, Mitsue Sano, Tsutomu Fukuwatari   +3 more
doaj   +1 more source

Reaction of Pyridoxal and Amino Acids in Methanol

Chemical and Pharmaceutical Bulletin, 1968
Reactions of amino acids and related amines with pyridoxal in methanol were studied by the changes of electronic absorption spectra. Most amino acids and amines formed Schiff bases, which existed in keto-enamine and enol-imine forms. Equilibrium between the two tautomeric forms was affected by the nature of amino acids or amine residues.
openaire   +3 more sources