Results 61 to 70 of about 1,181 (159)

ON THE URINARY EXCRETION OF 4-PYRIDOXIC ACID AND ITS SIGNIFICANCE

THE JOURNAL OF VITAMINOLOGY, 1956
Various factors such as diet. metabolic state of the whole body. especially blood circulation, and functions of the liver and kidneys, influence the excretion of PIC in urine which is assumed. in accordance with Schwartz (8), to have been chiefly formed from PAL by the aldehyde oxidase of the liver.
YAMADA, KOZO, SAWAKI, SHUNJI, OGAWA, EIICHI   +2 more
openaire   +3 more sources

Allelopathic Sugarcane Leaf Litter and Its Potential Use as Soil Mulching for Weed Management in Sugarcane Cultivation

Weed Research, Volume 66, Issue 1, January/February 2026.
ABSTRACT Sugarcane leaves, both green and fallen, left after harvest, are agricultural residues containing compounds that inhibit weed germination and seedling growth. This study evaluated their allelopathic effects and mulching potential for weed control.
Ramida Krumsri, Thanatsan Poonpaiboonpipat, Ukrit Samaksaman, Nitra Nuengchamnong, Chamroon Laosinwattana   +4 more
wiley   +1 more source

Icariin Alleviates Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice by Modulating the Gut–Lung Axis and Serum Metabolism

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of uncertain etiology with few specific and effective therapeutic agents approved for its treatment. We examined the underlying processes and the impact of icariin (ICA) on a bleomycin‐induced pulmonary fibrosis model.
Ting Zhang, Weiyi Gong, Cheng Huang, Hongkai Wang, Baojun Liu, Dawei Cui   +5 more
wiley   +1 more source

Urinary excretion of pyridoxine and 4‐pyridoxic acid in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1964
AbstractSeven patients with active rheumatoid arthritis excreted significantly less pyridoxine in the urine than controls when patient‐control pairs were fed identical constant diets while receiving no drugs. After a 10 mg. dose of pyridoxine hydrochloride, change in objectively measured stiffness appeared to be inversely related to change in urinary ...
A B, MCKUSICK, R W, SHERWIN, L G, JONES, J M, HSU   +3 more
openaire   +2 more sources

Periodontitis Salivary Microbiota Exacerbates Murine Rheumatoid Arthritis via Gut Dysbiosis and Immune Dysregulation

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
Salivary multiomics from healthy, PD, RA, and PD‐RA cohorts identified PD−/RA‐linked microbial and metabolic signatures. We then transplanted salivary microbiota from a PD donor or a healthy donor into collagen‐induced arthritis mice. PD microbiota colonized the gut, reshaped communities, weakened epithelial tight junctions, and provoked systemic ...
Ruiyang Ge, Rong Liu, Yingying Zhou, Ziyao Zhuang, Haowei Mao, Wenzheng Liao, Lei Han, Wenrong Yang, Fuhua Yan, Di Cui   +9 more
wiley   +1 more source

Expanding Role of Endogenous Biomarkers for Assessment of Transporter Activity in Drug Development: Current Applications and Future Horizon

Pharmaceutics
The evaluation of transporter-mediated drug–drug interactions (DDIs) during drug development and post-approval contributes to benefit–risk assessment and helps formulate clinical management strategies.
Vikram Arya, Joseph D. Ma, Kine Eide Kvitne   +2 more
doaj   +1 more source

Urinary excretion of B-group vitamins reflects the nutritional status of B-group vitamins in rats

Journal of Nutritional Science, 2013
We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating ...
Katsumi Shibata, Chisa Sugita, Mitsue Sano, Tsutomu Fukuwatari   +3 more
doaj   +1 more source

Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate (GCDCA‐S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1532-1542, December 2025.
Endogenous biomarkers for drug transporters are an emerging tool for the assessment of transporter‐mediated drug–drug interactions (DDI). Glycochenodeoxycholic acid 3‐O‐sulfate (GCDCA‐S) has been proposed as a Tier 2 biomarker of hepatic OATP1B3 and renal OAT3 transporters by the International Transporter Consortium.
Yuki Ujihira, Viktor Georgiev, Kayode Ogungbenro, Aleksandra Galetin   +3 more
wiley   +1 more source

Integration of Bioinformatics, Serum Pharmacochemistry, and Metabolomics to Reveal the Mechanisms of Danggui Buxue Decoction in Anti‐Rheumatoid Arthritis Through Inflammation and NF‐κB Signaling Pathway Regulation

Immunity, Inflammation and Disease, Volume 13, Issue 9, September 2025.
ABSTRACT Objective Rheumatoid arthritis (RA) remains a significant clinical challenge due to the limited efficacy and adverse effects associated with conventional treatments. Danggui buxue decoction (DBD), renowned for its qi‐tonifying, blood‐nourishing, and anti‐inflammatory properties, has shown promising potential in the management of RA. This study
Lianyun Du, Ye Zhai, Meixiu Luo, Lu Tang, Saiyue Qiu, Xin Jiang, Enpeng Wang, Zhi Pan   +7 more
wiley   +1 more source

Effectiveness of Pyridoxal‐5′‐Phosphate in PNPO Deficiency: A Systematic Review

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Pyridox(am)ine 5′‐phosphate oxidase (PNPO) deficiency is an ultrarare inherited neurometabolic disease, characterized by primarily neonatal‐onset B6‐responsive epileptic encephalopathies. Treatment often requires sustainable access to high‐quality pyridoxal‐5′‐phosphate (PLP, i.e., active vitamin B6), although some patients (also) respond to ...
Nina N. Stolwijk, Laura van Dussen, Niels D. Reijnhout, Marion M. M. G. Brands, Bregje Jaeger, Peter T. Clayton, Carla E. M. Hollak, Annet M. Bosch   +7 more
wiley   +1 more source