Results 131 to 140 of about 66,485 (345)

Status epilepticus in older adults: A critical review

open access: yesEpilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward   +5 more
wiley   +1 more source

Pyridoxine responsive epilepsy caused by a novel homozygous PNPO mutation

open access: yesMolecular Genetics and Metabolism Reports, 2016
We report a patient with anti-epileptic treatment refractory neonatal seizures responsive to pyridoxine. Biochemical analysis revealed normal markers for antiquitin deficiency and also mutation analysis of the ALDH7A1 (Antiquitin) gene was negative ...
B. Jaeger   +6 more
doaj   +1 more source

First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus

open access: yesThe FEBS Journal, EarlyView.
The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi   +15 more
wiley   +1 more source

Antidote Stocking at Hospitals in North Palestine [PDF]

open access: yes, 2007
Objective: The purpose of this study was to determine the availability and adequacy of antidote stocking at hospitals in north Palestine based on published guidelines for antidote stocking.
Al-Jabi W, Samah   +3 more
core   +1 more source

The disease‐linked R336C mutation in cystathionine β‐synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity

open access: yesThe FEBS Journal, EarlyView.
Cystathionine β‐synthase (CBS) is an essential enzyme involved in cysteine metabolism. The mutation R336C, associated with severe homocystinuria and of high incidence in Qatar, reduces its activity. Our research shows that this mutation does not destabilize the enzyme fold but subtly alters the tautomeric equilibrium of the PLP cofactor within the ...
Carolina Conter   +10 more
wiley   +1 more source

Aquaculture Asia, Vol. 10, No. 1, pp.1-50, January - March 2005 [PDF]

open access: yes, 2005
CONTENTS: Freshwater prawn culture in China and its market prospects, by Miao Weimin. Demise of wastewater-fed duckweed based aquaculture in Bangladesh, by Peter Edwards.

core  

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

open access: yesThe FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona   +11 more
wiley   +1 more source

SORPTION ISOTHERM OF PYRIDOXINE HYDROCHLORIDE ON GLAUCONITE

open access: yesКонденсированные среды и межфазные границы, 2017
Natural aluminosilicates are promising sorbents that can be used to separate and isolate biologically active substances, namely vitamins. Hydrochloride pyridoxine (vitamin B6) is an important biologically active compound necessary for the normal ...
Kotova Diana L.   +4 more
doaj   +1 more source

Old player, new roles: defining the role of the plastidial phosphorylase

open access: yesNew Phytologist, EarlyView.
Summary The plastidial phosphorylase (Pho1 or Phs1; E.C. 2.4.1.1) is a ubiquitous enzyme among plants that catalyzes the formation and degradation of glucans. Although the first report connecting Pho1 with starch metabolism came out > 80 years ago, its precise role is still a matter of debate.
David Seung   +2 more
wiley   +1 more source

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