Results 131 to 140 of about 28,846 (248)

Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review

open access: yesCurrent Developments in Nutrition
Background: Pyridoxine-dependent epilepsy (PDE) is identified as a rare neurometabolic disease marked by biallelic pathogenic mutations of the ALDH7A1 gene.
Ali Jafari   +5 more
doaj  

Exploring the Stability and Substrate Profile of Transaminase from Silicibacter pomeroyi with Ancestral Sequence Reconstruction

open access: yesChemBioChem, Volume 26, Issue 13, July 11, 2025.
This study describes the successful identification of ancestral sequences N50 and N49, which have a longer half‐life of approximately four and two times the wild‐type Sp‐amine transaminase, respectively.. This approach effectively enhances the thermal stability of the transaminase.
Luyao Zhao   +4 more
wiley   +1 more source

Mammalian Tolerance to Amino Acid Heterochirality

open access: yesChemBioChem, Volume 26, Issue 13, July 11, 2025.
Organisms preferentially use l‐amino acids (l‐AAs). However, de novo synthesized l‐AAs are in part converted to d‐AAs. The ribosome has a robust system to use l‐AAs for protein synthesis, whereas non‐ribosomal synthesis can also use d‐AAs. Furthermore, some AA residues can be post‐translationally isomerized through enzymatic or spontaneous processes ...
Sakiko Taniguchi   +4 more
wiley   +1 more source

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