Results 61 to 70 of about 28,111 (262)

Designing Enzymatic Reactivity with an Expanded Palette

ChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

POTENTIOMETRIC AND CONDUCTIMETRIC STUDIES OF CHEMICAL EQUILIBRIA FOR PYRIDOXINE HYDROCHLORIDE IN AQUEOUS SOLUTIONS: SIMPLE EXPERIMENTAL DETERMINATION OF PKA VALUES AND ANALYTICAL APPLICATIONS TO PHARMACEUTICAL ANALYSIS

Eclética Química, 2018
The combination of two low-cost classical procedures based on titrimetric techniques is presented for the determination of pyridoxine hydrochloride in pharmaceuticals samples.
Thiago de Almeida Drumond dos Santos, Diego Oliveira da Costa, Samuel Silva da Rocha Pita, Felipe Silva Semaan   +3 more
doaj   +1 more source

Fluorescence Spectroscopy of Flour Fractions and Dough: Analysis of Spectral Differences and Potential to Improve Wheat Quality Prediction

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Spectroscopy of wheat kernels and flour has been used as a rapid tool to assess wheat quality, but predictions still lack in accuracy for most quality parameters except for protein content. To enable an improved prediction of further quality characteristics, new approaches are needed.
Denise Ziegler, Lukas Buck, Katharina Anne Scherf, Lutz Popper, Bernd Hitzmann   +4 more
wiley   +1 more source

Formulation of dispersible isoniazid/pyridoxine fixed-dose combination tablets for isoniazid preventive therapy in pediatrics

Cogent Medicine, 2020
Objective: Oral dispersible isoniazid 50 mg/pyridoxine 6.25 mg fixed-dose combination (FDC) tablets were formulated for Isoniazid Preventive Therapy in pediatrics weighing less than 5 kg.
M. W. Mwangi, L. J. Tirop, P. M. Njogu, J. M. Bururia, N. M. Njuguna, E. G. Mbae   +5 more
doaj   +1 more source

Manifestation of "Wing-Beating" Tremors Along With Appearance of the "Giant Panda" Sign on Brain MRI in Neuro Wilson's Disease Due to Treatment Failure: A Case Report. [PDF]

Clin Case Rep
ABSTRACT We report a patient of neuro Wilson's disease who presented with “wing‐beating” tremors and “giant panda” sign on magnetic resonance imaging, 1 year after initiation of treatment with zinc acetate. We focus on the importance of initiating copper chelator therapy as the first line treatment as it improves the prognosis and prevents irreversible
Dosi RV, Shah KP, Sarvaiya JN, Kadakia DJ, Patel DR, Mishra A.   +5 more
europepmc   +2 more sources

Chemoenzymatic Total Synthesis of Lansai B

Chemistry – A European Journal, EarlyView.
Lansai B was obtained in a chemoenzymatic approach from the small building block 5‐bromoindole utilizing two enzymes. Applying a tryptophan synthase and a further characterized C3‐methyltransferase the sterically demanding framework is constructed within just six steps. After late‐stage Suzuki‐coupling and n‐methylation the natural product was isolated.
Marcel Schatton, Mona Haase, Julia Tenhaef, Catharina Gronkowsky, Stephan Noack, Jörg Pietruszka   +5 more
wiley   +1 more source

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, EarlyView.
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source

Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery

ChemMedChem, EarlyView.
The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley   +1 more source

Does pyridoxine control behavioral symptoms in adult patients treated with levetiracetam? Case series from UAE

Epilepsy and Behavior Case Reports, 2015
Behavioral symptoms are known side effects of levetiracetam. Previous case series in children and adolescents have demonstrated the potential effect of pyridoxine in ameliorating these symptoms.
Taoufik Alsaadi, Khadija El Hammasi, Tarek M. Shahrour   +2 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source