Results 11 to 20 of about 147,452 (301)

Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility Safety, and PK

, 2022
A series of novel heteroaromatic biphenyl-methyl-pyrimidine analogues were designed via hybridization of privileged structures of two HIV-1 inhibitors.
Erik De Clercq, Christophe Pannecouque, Li Ding (16240), Chunlin Zhuang (1845721), Fen-Er Chen (2495434), Chunlin Zhuang, Li Ding, Erik De Clercq (7541327), Christophe Pannecouque (496139), Fen-Er Chen   +9 more
core   +3 more sources

Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues [PDF]

, 2022
Analogues of the canonical nucleosides have a longstanding presence and proven capability within medicinal chemistry and drug discovery research.
Miller, Gavin J.; id_orcid, Benckendorff, Caecilie M.M., Miller, Gavin J., Benckendorff, Caecilie, Slyusarchuk, Valentyna D., Huang, Ningwu, Smith, Mark, Lima, Marcelo A.   +7 more
core   +1 more source

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]

, 1989
Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland, Schultz, Günter, Burde, R.   +2 more
core   +1 more source

Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency

Molecules, 2020
Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the ...
Kirill P. Cheremnykh, Victor A. Savelyev, Sergey A. Borisov, Igor D. Ivanov, Dmitry S. Baev, Tatyana G. Tolstikova, Valentin A. Vavilin, Elvira E. Shults   +7 more
doaj   +1 more source

Experimental and quantum chemical studies of the electronic absorption spectra of pyrimidine derivatives

Journal of Saudi Chemical Society, 2011
The electronic absorption spectra of different pyrimidine derivatives have been measured experimentally and calculated theoretically by the PPP and CNDO/S methods.
M. Mogren, K. Al-Farhan, Ahmed A. Hasanein   +2 more
doaj   +1 more source

Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier

Molecules, 2020
This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8.
Shaikha S. AlNeyadi, Naheed Amir, Mohammad A. Ghattas, Noor Atatreh, Shaikha S. Alketbi, Ruba Al Ajeil, Abdu Adem   +6 more
doaj   +1 more source

Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms.

PLoS ONE, 2013
BackgroundAfrican trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.Methodology/principal findingsPyrimidine requirements for
Juma A M Ali, Daniel N A Tagoe, Jane C Munday, Anne Donachie, Liam J Morrison, Harry P de Koning   +5 more
doaj   +1 more source

Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances

Frontiers in Chemistry, 2021
In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies.
Muhammad Faisal, Aamer Saeed
doaj   +1 more source

1-Methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine

IUCrData, 2017
In the crystal, molecules of the title compound, C12H10N4, stack in a head-to-tail manner along the b direction through π–π stacking interactions between both portions of the pyrazolopyrimidine ring system.
Mohamed El Hafi, Mohammed Boulhaoua, Abdelhanine Essaghouani, Youssef Ramli, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A_2A/A_2B adenosine receptor antagonists

, 2022
A series of novel dual A2A/A2B AR antagonists based on the triazole-pyrimidine-methylbenzonitrile core were designed and synthesised. The A2A AR antagonist cAMP functional assay results were encouraging for most target compounds containing quinoline or ...
Xinzhen Fu (9201722), Tiantian Lin (6718970), Lin Guo (113004), Zeping Xie (543927), Ming Liu (105953), Zhi Li (72309), Shizhou Gong (12644246), Shumin Zhang (187205), Lijuan Kou (12644243), Maolei Xu (4689487)   +9 more
core   +1 more source