Results 11 to 20 of about 161,675 (297)

Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives [PDF]

Journal of Chemistry, 2013
A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives ...
Yuh-Wen Ho, Maw Cherng Suen
doaj   +2 more sources

Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility Safety, and PK

, 2022
A series of novel heteroaromatic biphenyl-methyl-pyrimidine analogues were designed via hybridization of privileged structures of two HIV-1 inhibitors.
Erik De Clercq, Christophe Pannecouque, Li Ding (16240), Chunlin Zhuang (1845721), Fen-Er Chen (2495434), Chunlin Zhuang, Li Ding, Erik De Clercq (7541327), Christophe Pannecouque (496139), Fen-Er Chen   +9 more
core   +3 more sources

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]

, 1989
Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland, Schultz, Günter, Burde, R.   +2 more
core   +1 more source

Experimental and quantum chemical studies of the electronic absorption spectra of pyrimidine derivatives

Journal of Saudi Chemical Society, 2011
The electronic absorption spectra of different pyrimidine derivatives have been measured experimentally and calculated theoretically by the PPP and CNDO/S methods.
M. Mogren, K. Al-Farhan, Ahmed A. Hasanein   +2 more
doaj   +1 more source

Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier

Molecules, 2020
This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8.
Shaikha S. AlNeyadi, Naheed Amir, Mohammad A. Ghattas, Noor Atatreh, Shaikha S. Alketbi, Ruba Al Ajeil, Abdu Adem   +6 more
doaj   +1 more source

Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms.

PLoS ONE, 2013
BackgroundAfrican trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.Methodology/principal findingsPyrimidine requirements for
Juma A M Ali, Daniel N A Tagoe, Jane C Munday, Anne Donachie, Liam J Morrison, Harry P de Koning   +5 more
doaj   +1 more source

Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances

Frontiers in Chemistry, 2021
In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies.
Muhammad Faisal, Aamer Saeed
doaj   +1 more source

Synthesis of Pyrimidines and Condensed Pyrimidines [PDF]

Bulletin of the Chemical Society of Japan, 1973
Abstract A new one-step synthesis of pyrimidines and condensed pyrimidines by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.
openaire   +1 more source

1-Methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine

IUCrData, 2017
In the crystal, molecules of the title compound, C12H10N4, stack in a head-to-tail manner along the b direction through π–π stacking interactions between both portions of the pyrazolopyrimidine ring system.
Mohamed El Hafi, Mohammed Boulhaoua, Abdelhanine Essaghouani, Youssef Ramli, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives

Molecules, 2006
2–Amino–4-phenyl–5,6,7,8–tetrahydroquinoline–3–carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2–benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards
Mohamed Abdelhamed Morsy, Yehya Mahmud Elkholy   +1 more
doaj   +1 more source