Results 31 to 40 of about 147,452 (301)

Pyrimidine-Based Mononuclear and Dinuclear Iridium(III) Complexes for High Performance Organic Light-Emitting Diodes

, 2016
Containing two nitrogen atoms, the electron-deficient pyrimidine ring has excellent coordinating capability with transition metal ions. However, compared with the widely used pyridine ring, applications of the pyrimidine ring in phosphorescent Ir­(III ...
Guijiang Zhou (1406068), Boao Liu (3354965), Kaini Zhang (3377384), Zhao Feng (3377381), Jiang Zhao (353820), Jing-Shuang Dang (1863709), Xiaolong Yang (31447)   +6 more
core   +1 more source

A Review on Fused Pyrimidine Systems as EGFR Inhibitors and Their Structure–Activity Relationship

Frontiers in Chemistry, 2022
Epidermal growth factor receptor (EGFR) belongs to the family of tyrosine kinase that is activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular proliferation process, differentiation, and apoptosis.
Tanuja T. Yadav, Gulam Moin Shaikh, Maushmi S. Kumar, Meena Chintamaneni, Mayur YC   +4 more
doaj   +1 more source

2-Amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one

IUCrData, 2018
The asymmetric unit of the title compound, C6H7N5O, consists of two molecules with almost identical conformations. In the crystal, inversion dimers linked by pairs of N—H...N hydrogen bonds occur for both molecules; further N—H...N and N—H...O hydrogen ...
Sanae Lahmidi, Mohamed El Hafi, Nada kheira Sebbar, Nadeem Abad, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562

, 2022
A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety via N-containing bridge and then evaluated for their cytotoxic activity against MCF-7 and K562 cell lines.
Nehad M. El-Dydamony (12315278), Rana M. Abdelnaby (12315281), Omaima Ali (12315287), Rasha R. Fakhr Eldeen (12315293), Amira A. Helwa (12315296), Mohamed I. Fahmy (12315290), Rasha Abdelhady (12315284)   +6 more
core   +1 more source

Novel Selective and Potent EGFR Inhibitor that Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer

Molecules, 2016
Treating patients suffering from EGFR mutant non-small cell lung cancer (NSCLC) with first-generation EGFR tyrosine kinase inhibitors (EGFR TKI) provides excellent response rates.
Yanxia Li, Zhendong Song, Yue Jin, Zeyao Tang, Jian Kang, Xiaodong Ma   +5 more
doaj   +1 more source

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines

Molecules, 2020
A series of 34 new pyrimido[2,1-c][1,2,4]triazine-3,4-diones were synthesized and fully characterized using IR, NMR, MS, and microanalytical analysis. In vitro investigation of 12 compounds of this series revealed promising antimicrobial activity of the ...
Islam H. El Azab, Nadia A.A. Elkanzi
doaj   +1 more source

Uracil Compounds As Inhibitors For Glutamate Oxaloactate Tansaminase (GOT) In Serum Of Some Leukemia Patients [PDF]

Kirkuk Journal of Science, 2015
Effect of Uracil’s derivatives on enzyme glutamate oxaloacetate transaminase (GOT) for sample of normal human and some types of leukemia patients, acute lymphatic(ALL) (11 cases), acute mylosyticl (AML) (4 cases), acute mylomonocyticl (AMOL) (2cases ...
Nadia Q. Haj
doaj   +1 more source

A Facile and Effective Four-Component Synthesis of Benzo[4,5]imidazo[1,2-a]-pyrimidine-3-carboxamides Based on Diketene

, 2019
A novel and efficient four component reaction involving diketene, primary amines, aromatic aldehydes and 2-amino-benzimidazole in the presence of I2 in refluxing EtOAc for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimidine-3-carboxamides is reported ...
Majid M. Heravi (3939749), Manizheh Ghanbarian (8067164), Seyed Yahya Shirazi Beheshtiha (8067167)   +2 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis

Journal of Lipid Research
A key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis.
Julia A. Pinette, Jacob W. Myers, Woo Yong Park, Heather G. Bryant, Alex M. Eddie, Genesis A. Wilson, Claudia Montufar, Zayedali Shaikh, Zer Vue, Elizabeth R. Nunn, Ryoichi Bessho, Matthew A. Cottam, Volker H. Haase, Antentor O. Hinton, Jessica B. Spinelli, Jean-Philippe Cartailler, Elma Zaganjor   +16 more
doaj   +1 more source