Results 51 to 60 of about 161,675 (297)

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2018
Cytidine triphosphate synthase catalyzes the synthesis of cytidine 5′-triphosphate (CTP) from uridine 5′-triphosphate (UTP), the final step in the production of cytidine nucleotides.
Heidy Y. Narvaez-Ortiz, Andrea J. Lopez, Nishith Gupta, Barbara H. Zimmermann   +3 more
doaj   +1 more source

Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage.

, 2010
International audienceThis article describes a synthetic route to generate two purine-pyrimidine and pyrimidine heterodinucleosides. Both microwave activated regioselective alkylation using hydride and copper-catalyzed-azide-alkyne-cycloaddition (CuAAC ...
Elchinger, Pierre-Henri, Lucas, Romain, Faugeras, Pierre-Antoine, Zerrouki, Rachida, R. Zerrouki, R. Lucas, P. A. Faugeras, P. H. Elchinger   +7 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents

Molecules, 2021
Background: Anticancer drug resistance is a challenging phenomenon of growing concern which arises from alteration in drug targets. Despite the fast speed of new chemotherapeutic agent design, the increasing prevalence of this phenomenon requires further
Valentina Noemi Madia, Alice Nicolai, Antonella Messore, Alessandro De Leo, Davide Ialongo, Valeria Tudino, Francesco Saccoliti, Daniela De Vita, Luigi Scipione, Marco Artico, Samanta Taurone, Ludovica Taglieri, Roberto Di Santo, Susanna Scarpa, Roberta Costi   +14 more
doaj   +1 more source

A Facile and Effective Four-Component Synthesis of Benzo[4,5]imidazo[1,2-a]-pyrimidine-3-carboxamides Based on Diketene

, 2019
A novel and efficient four component reaction involving diketene, primary amines, aromatic aldehydes and 2-amino-benzimidazole in the presence of I2 in refluxing EtOAc for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimidine-3-carboxamides is reported ...
Majid M. Heravi (3939749), Manizheh Ghanbarian (8067164), Seyed Yahya Shirazi Beheshtiha (8067167)   +2 more
core   +1 more source

Synthesis of various fused pyrimidine rings with their pharmacological and antimicrobial evaluation [PDF]

, 2014
Various fused pyrimidine such as furo[2,3-d]pyrimidine, triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under different reaction conditions ...
Marzouk Magda I., Mounir Salem A., Mahmoud Naglaa F.   +2 more
core   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source