Results 61 to 70 of about 147,452 (301)
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
4-(Prop-2-yn-1-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine
IUCrData, 2017 The asymmetric unit of the title compound, C8H6N4S, consists of two independent molecules differing in the orientation of the side chain. In the crystal, molecules form dimers through N—H...N hydrogen bonds.
Mohamed El Hafi +5 more
doaj +1 more source
Molecules, 2021 Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein, series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in vivo for their antitumor activity.
Naglaa M. Ahmed +3 more
doaj +1 more source
Localizable Fluorescent Metal Ion Indicators With Tunable Colors
Advanced Science, EarlyView.A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self‐labeling proteins yields bright, color‐tunable potassium probes that permit wash‐free live‐cell imaging, revealing dynamic potassium efflux in stimulated neurons.
Ming‐Ming Wang +3 more
wiley +1 more source
Synthesis of various fused pyrimidine rings with their pharmacological and antimicrobial evaluation [PDF]
Journal of the Serbian Chemical Society, 2014 Various fused pyrimidine such as furo[2,3-d]pyrimidine, triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under different reaction conditions ...
Mounir Salem A. +2 more
doaj +1 more source
, 1969 Pyrimidine dimers of cyclobutane type were found in the RNA of tobacco mosaic virus when irradiated free (about 1.0 per photoreactivable lesion), but not in the RNA irradiated inside the virus.
Carpenter, J. M., Kleczkowski, A.
core +1 more source
Advanced Science, EarlyView.Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu +7 more
wiley +1 more source
Crystal structure of 4,6-dichloro-5-methylpyrimidine
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C5H4Cl2N2, is essentially planar with an r.m.s. deviation for all non-H atoms of 0.009 Å. The largest deviation from the mean plane is 0.016 (4) Å for an N atom. In the crystal, molecules are linked by pairs of C—H...N hydrogen bonds,
Meriem Medjani +4 more
doaj +1 more source
Advanced Science, EarlyView.Molecular dipole engineering in dendritic perylene diimide polymers through nitrogen‐rich heterocyclic linkers amplifies the built‐in electric field, enabling sub‐picosecond charge separation and efficient multi‐electron accumulation. This structure–dynamics–performance relationship establishes a versatile design strategy for high‐performance organic ...
Ying‐Xin Qiao +11 more
wiley +1 more source
Elevated Expression of Pyrimidine Nucleoside Phosphorylase (PyNPase) in Renal Cell Carcinoma Tissue [PDF]
, 2001 Background: Pyrimidine nucleoside phosphorylase (PyNPase) is an enzyme that converts 5'-deoxy-5-fluorouridine to 5- fluorouracil. PyNPase is identical to platelet-derived endothelial cell growth factor (PD-ECGF), and has angiogenic activity.
Maeda, Kanenori +4 more
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