Localizable Fluorescent Metal Ion Indicators With Tunable Colors
Advanced Science, EarlyView.A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self‐labeling proteins yields bright, color‐tunable potassium probes that permit wash‐free live‐cell imaging, revealing dynamic potassium efflux in stimulated neurons.
Ming‐Ming Wang +3 more
wiley +1 more source
Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by Docking Studies [PDF]
, 2023 Ahmed K. B. Aljohani +11 more
openalex +1 more source
Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD [PDF]
, 2018 The dihydroorotase (DHOase) domain of the multifunctional protein carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase (CAD) catalyzes the third step in the de novo biosynthesis of pyrimidine nucleotides in animals.
D'Abramo, Marco +4 more
core +1 more source
Advanced Science, EarlyView.Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu +7 more
wiley +1 more source
1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
IUCrData, 2018 The title molecule, C6H6N4O, is essentially planar [dihedral angle between the rings = 0.46 (9)°]. The crystal structure consists of sheets of molecules lying parallel to (\overline{1}11) formed by a combination of N—H...O, C—H...O and C—H...H hydrogen ...
Mohamed El Hafi +5 more
doaj +1 more source
Comparative analysis between RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise [PDF]
, 2023 Giuliana Calia +3 more
openalex +1 more source
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]
, 2018 Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona +6 more
core +3 more sources
Advanced Science, EarlyView.Molecular dipole engineering in dendritic perylene diimide polymers through nitrogen‐rich heterocyclic linkers amplifies the built‐in electric field, enabling sub‐picosecond charge separation and efficient multi‐electron accumulation. This structure–dynamics–performance relationship establishes a versatile design strategy for high‐performance organic ...
Ying‐Xin Qiao +11 more
wiley +1 more source
Electronic structure of the molecule based magnet Cu PM(NO3)2 (H2O)2
, 2007 We present density functional calculations on the molecule based S=1/2 antiferromagnetic chain compound Cu PM(NO3)2 (H2O)2; PM = pyrimidine. The properties of the ferro- and antiferromagnetic state are investigated at the level of the local density ...
A. U. B. Wolter +7 more
core +1 more source
Advanced Energy Materials, EarlyView.We identify two decisive levers for SAM interfaces: molecular design (carboxylic acid‐based, phosphonic acid, other anchoring chemistries, and polymeric SAMs) and mixing routes (co‐assembly, in situ assembly, pre‐ and post‐treatment). Coordinated tuning of headgroups and assembly pathways optimises energy alignment and film formation, suppresses ...
Jiaxu Zhang, Bochun Kang, Feng Yan
wiley +1 more source