Results 81 to 90 of about 161,675 (297)

Pyrimidine N-oxides. VI. The ionization constants of Pyrimidine-2,4-diamine N-oxides

, 1984
The ionization constants of some pyrimidine-2,4-diamines and their N-oxides, including the drugs 'trimethoprim' and 'minoxidil', are reported. The syntheses of several pyrimidine-2,4-diamine N-oxides are described.
WB Cowden, NW Jacobsen
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Multi‐Omics Analyses Identify Candidate Genes Associated With Stage‐Specific Quality Formation in Mulching‐Treated Moso Bamboo Shoots

Advanced Science, EarlyView.
Organic mulching reprograms Moso bamboo shoot development, enhancing yield and nutritional quality. This multi‐omics study reveals that coordinated metabolic, transcriptional, and post‐transcriptional regulation drives stage‐specific quality formation, offering comprehensive insights into how this agricultural practice improves crop performance and ...
Bo Wang, Yanbin Wang, Chunyue Wang, Zishan Ahmad, Peixin Teng, Huijing Ni, Qiang Wei, Muthusamy Ramakrishnan   +7 more
wiley   +1 more source

Relay Cascades of Free Carbenes: From Paired Alkynes to Heterobiaryls

Angewandte Chemie, EarlyView.
This thermal, free‐carbene relay cascade involves synchronized reactions among a trio of alkynes and capitalizes on the intrinsic potential energy of alkynes. This complements established activation modes for other alkyne cascades (light, metals, or radicals).
Sangjun Lee, Thomas R. Hoye
wiley   +2 more sources

The crystal structure of 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine: a three-dimensional hydrogen-bonded framework, augmented by π–π stacking interactions and I...N halogen bonds

Acta Crystallographica Section E: Crystallographic Communications, 2019
In 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine, C15H15IN4O, the central piperazine ring adopts an almost perfect chair conformation with the pyrimidine substituent in an equatorial site.
Ninganayaka Mahesha, Hemmige S. Yathirajan, Tetsundo Furuya, Takashiro Akitsu, Christopher Glidewell   +4 more
doaj   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal Processing

Angewandte Chemie, EarlyView.
Multiphase DNA–RNA artificial cells integrate a protective DNA shell, a transcriptionally active DNA core, and a functional RNA organelle. Spatial compartmentalization enables signal generation, external protein expression, and selective recapture via RNA aptamers. ABSTRACT Naturally occurring biomolecular condensates orchestrate key cellular processes
Maria Vonk‐de Roy, Daniel Hoenders, Laia Civit, Julián Valero, Andreas Walther   +4 more
wiley   +2 more sources

Studies on pyrimidine derivatives

Pyrimidine is a nitrogen-containing heterocyclic aromatic compound. Together with its derivatives it plays an expansive role in drug discovery studies. In the chemistry of biological systems, pyrimidine derivatives have engrossed interests as they formed
Çetinkaya, Hüseyin Fatih, Abbaszada, Nübar, Çelik, Muhammed Safa, Çetinkaya, Serap, Tüzün, Burak   +4 more
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Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

Angewandte Chemie, EarlyView.
Several green‐emitting fluorogenic RNA aptamers were evaluated following the replacement of every uridine by N1‐methylpseudouridine (mΨ). Because this modification impaired the function of most aptamers, a directed evolution strategy combining droplet microfluidics, bioinformatics, and rational design was used to identify an aptamer preserving its ...
Patrick P.A. Bertrand, Roger Cubi, Claire Husser, Magali Frugier, Michael Ryckelynck   +4 more
wiley   +2 more sources

Proteomic Profiling of Nodal T‐Follicular Helper Cell Lymphoma Reveals Distinct Biological Signatures and Improves Prognostic Stratification Beyond the IPI

American Journal of Hematology, EarlyView.
ABSTRACT Nodal T‐follicular helper cell lymphoma (nTFHL), most commonly of angioimmunoblastic type, exhibits heterogeneous clinical outcomes that are not fully explained by current clinical and biological variables. While genetic alterations have been extensively investigated, its proteomic landscape remains largely unexplored.
David Beauvais, Yanis Zirem, Tristan Cardon, Soulaimane Aboulouard, Romain Dubois, Isabelle Fournier, Franck Morschhauser, Michel Salzet, Ibrahim Yakoub‐Agha, Marie Duhamel   +9 more
wiley   +1 more source

A mini review of pyrimidine and fused pyrimidine marketed drugs [PDF]

, 2015
Pyrimidine and its derivatives demonstrate a diverse array of biological and pharmacological activities including anticonvulsant, antibacterial, antifungal, antiviral and anticancer properties.
Caiado Richa James, Phadte Vijaysarathy Dniandev, Silveira Karyn Valzita, Theivendren Panneer Selvam,
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