Results 91 to 100 of about 147,452 (301)

Ein Ruthenium‐(Ph‐BPE) Katalysator für die asymmetrische Alkinylierung von Fluoral: Enantioselektion aus einem von 12 fluxionalen Komplexen mit rutheniumzentrierter Stereogenität

Angewandte Chemie, EarlyView.
Dies beschreibt die ersten enantioselektiven Alkinylierungen wässrigen Fluorals. Diese Prozesse werden durch einen Iodid‐gebundenen Ruthenium‐(Ph‐BPE)‐Komplex katalysiert, welcher als oktaedrischer Metallkomplex in 12 verschiedenen stereoisomeren Formen vorliegen kann.
Weijia Shen, Sebastian Höthker, Colin E. Hayter, Nicholas K. Bowers, Andrea Pellegrini, Stefan Grimme, Michael J. Krische   +6 more
wiley   +1 more source

Synthesis and Antimicrobial Evaluation of Novel Pyrazole, Imidazole and Pyrimidine Derivatives Possessing Imidazo[4,5-b]indol Moiety

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2019
In this study, novel pyrazole, imidazole, pyrimidine derivatives bearing imidazo[4,5-b]indol moiety were successfully synthesized and their chemical structures were identified and confirmed by different spectral techniques.
Nadia Ali Ahmed Elkanzi, Amira Atef Ghoneim, Hajer Hrichi   +2 more
doaj   +1 more source

Synthesis of Carbocyclic C-Nucleosides Containing Nonnatural Pyrimidine Bases

, 1996
A series of new carbocyclic C-nucleosides with a cis-4′-(hydroxymethyl)cyclopent-2′-enyl sugar moiety and unnatural pyrimidine bases (2–6) were synthesized in racemic form in two steps starting from the easily accessible cyclic carbonate ...
Scheffold, Rolf, Hildbrand, Stefan, Stefan Hildbrand, Leumann, Christian, Christian Leumann, Rolf Scheffold   +5 more
core   +1 more source

Brain pyrimidine nucleotide synthesis and Alzheimer disease [PDF]

, 2019
Many patients suffering late-onset Alzheimer disease show a deficit in respiratory complex IV activity. The de novo pyrimidine biosynthesis pathway connects with the mitochondrial respiratory chain upstream from respiratory complex IV.
Gaudó, Paula, Jiménez-Salvador, Irene, Bayona Bafaluy, M. Pilar, Jimenez Salvador, Irene, Meade, Patricia, Ferrer, Isidro (Ferrer Abizanda), Andrés-Benito, Pol, Ferrer, Isidro, Ruiz Pesini, Eduardo, Pesini, Alba, Montoya, Julio, Garrido-Pérez, Nuria, Ruiz-Pesini, Eduardo, Andrés Benito, Pol, Garrido Pérez, Nuria, Pesini, Pedro, Iglesias, Eldris, Bayona-Bafaluy, M Pilar   +17 more
core   +1 more source

BIOLOGICALLY ACTIVE PYRIMIDINE HYDARZONES

, 2015
Pyrimidine constitutes an important class of heterocycles in drug discovery & is very well known for their anticancer, antimicrobial, antioxidant & antiviral activities.
Shukla, Chhama, Luhach, Kanishk, Yadav, Rajender, Srivastav, Sanchit   +3 more
core   +1 more source

Unlocking Catalyst Activation as a Critical Bottleneck in Cross‐Coupling Reactions: Room‐Temperature Couplings of Weak Nucleophiles Enabled by [Pd(1‐MeNAP)TFA]2 Precatalysts

Angewandte Chemie International Edition, EarlyView.
In many Pd‐catalyzed cross‐couplings, catalyst performance has been found to be limited by catalyst activation. Methylnaphthyl (MeNAP) palladium trifluoroacetate dimers are presented as easy‐to‐store and easy‐to‐handle precursors, which rapidly activate under reaction conditions, even when only weakly coordinating, non‐reducing nucleophiles are present.
Sourav Manna, Henric F. Janning, Nikolaos V. Tzouras, Jane Anto Simplica Sagayaraj, Fadil Faizal Mannighayil, Angelino Doppiu, Lukas J. Gooßen   +6 more
wiley   +1 more source

The study of the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method

Журнал органічної та фармацевтичної хімії, 2019
Aim. To study profoundly the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method. Results and discussion. For the derivatives of 6-heterylthieno[2,3-
Sergiy V. Vlasov, Sergiy M. Kovalenko, T. P. Osolodchenko, V. S. Vlasov   +3 more
doaj   +1 more source

Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides

, 1997
Two cytoplasmic forms of pyrimidine nucleotidase (PN-I and PN-II) have been purified from human erythrocytes to apparent homogeneity and partially characterized.
Ruggieri, Silverio, Emanuelli, Monica, Monica Emanuelli, Amici, Adolfo, Adolfo Amici, Raffaelli, Nadia, Giulio Magni, Nadia Raffaelli, MAGNI G., Magni, Giulio, Silverio Ruggieri   +10 more
core   +1 more source

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source