Results 101 to 110 of about 161,675 (297)

Synthesis of Carbocyclic C-Nucleosides Containing Nonnatural Pyrimidine Bases [PDF]

, 1996
A series of new carbocyclic C-nucleosides with a cis-4′-(hydroxymethyl)cyclopent-2′-enyl sugar moiety and unnatural pyrimidine bases (2–6) were synthesized in racemic form in two steps starting from the easily accessible cyclic carbonate ...
Scheffold, Rolf, Hildbrand, Stefan, Stefan Hildbrand, Leumann, Christian, Christian Leumann, Rolf Scheffold   +5 more
core   +1 more source

The use of pyrimidine derivatives as adsorbents for the removal and extraction of heavy metal ions

Pyrimidine and pyrimidine derivatives, which are included in heterocyclic compounds, are used in various applications in fields such as pharmaceutical medicine, biochemistry, analytical chemistry, polymer chemistry, coordination chemistry, and ...
Çaylak, Osman, Tüzün, Burak
core  

Basophilic Stippling Unmasks Pyrimidine 5′‐Nucleotidase Deficiency in a G6PD‐Deficient Patient

American Journal of Hematology, EarlyView.
Victor Bobée, Stéphane Moutereau, Maïssa Souissi, Pierre Lebreton, Loïc Garcon   +4 more
wiley   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

SYNTHESIS OF PYRIMIDINE NUCLEOSIDE ANALOGUES.

, 1968
SYNTHESIS OF PYRIMIDINE NUCLEOSIDE ...
ALFRED JR. CHAN (7960880)
core   +3 more sources

Calculation of pKa values some 2-sübstituted pyrimidine derivatives

, 2015
Bu çalışmada on dört adet bazı perimidin türevi bileşiklerin (2-benzil-1H-perimidin (1), 2-(2-florobenzil)-1H-perimidin (2), 2-(3-florobenzil)-1H-perimidin (3), 2-(4-florobenzil)-1H-perimidin (4), 2-(2-bromobenzil)-1H-perimidin (5), 2-(3-bromobenzil)-1H ...
Tanyel, Tolga
core  

Role of Pyrimidine Derivatives in the Treatment of Cancer [PDF]

The study of the chemistry of pyrimidines is contributing to the expansion of research into the therapeutic applications of these compounds. In the field of medicinal chemistry, the sheer number of pyrimidine synthesis methods and reactions that are ...
kumar, Subham, Sarwade, Prakash Pralhad, Maurya, Chandresh, Gaisamudre (Sarwade), Kavita Narayan, Dangwal, Kiran, Srinandhinidevi, K. M., Otia, Mihir, Prakash, Jay   +7 more
core   +1 more source

Synthetic Elaboration, DFT Profiling, and Molecular-Dynamics-Guided Computational Validation Toward Anti-Diabetic Therapeutics: Tailored Pyrimidine-Derived Pyrazole-Thiadiazole Hybrid Scaffolds

Pharmaceuticals
Background/Objectives: Diabetes mellitus (DM) is a critical metabolic condition with escalated blood glucose levels caused by insulin resistance, restricted insulin production, and the activity of alpha-amylase and alpha-glucosidase enzymes.
Nahed Sail Alharthi
doaj   +1 more source

Pyrimidine N-Oxides. II. The Synthesis of Some Amino- and Imino-pyrimidine N-Oxides and Related Compounds

, 1979
Substituent effects on the peroxy acid oxidation of some pyrimidine-2,4,6-triamines are reported together with the synthesis of new N'-methylpyrimidine N-oxides and a pyrimidine N,N'-dioxide.
WB Cowden, NW Jacobsen
core   +1 more source

Induction and Enhancement of Bacteriocin Production (Review)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley   +1 more source