Results 101 to 110 of about 147,452 (301)
A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate
Angewandte Chemie International Edition, EarlyView.Nucleoside‐5′‐triphosphates (NTPs) are essential components for the generation of nucleic acids, yet their chemical synthesis is hindered by the low yield of nucleoside phosphorylation. Here, we present a universal, two‐enzyme nucleoside‐to‐NTP cascade that is driven by polyphosphate.
Jonathan P. Suess +1 more
wiley +1 more source
Studies on pyrimidine derivatives
Pyrimidine is a nitrogen-containing heterocyclic aromatic compound. Together with its derivatives it plays an expansive role in drug discovery studies. In the chemistry of biological systems, pyrimidine derivatives have engrossed interests as they formed
Çetinkaya, Hüseyin Fatih +4 more
core
The evolution of pyrimidine bases
Evolution occurs when genes in a population of cells change in sequence and frequency over time and dominate by modification. However, in the evolutionary process, before the formation of cells, there must also be compounds that form these cells.
Kebabci, Özgür, Tüzün, Burak
core
Sustainable Pd‐Catalyzed Aminations “on Dirty Water”
Angewandte Chemie International Edition, EarlyView.Aminations, done safely yet neat, and therefore, quickly, using low levels of Pd, in “dirty water” that must contain 30% KOH; not NaOH, and not at 5%,10%, 20%, 40%, or 50% KOH. Moreover, no base sensitivity of functional groups! Very cool. Thank you, Nature.
Erfan Oftadeh +4 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.The first enantioselective alkynylations of aqueous fluoral are described. These processes are catalyzed by an iodide‐bound ruthenium‐(Ph‐BPE)‐catalyst; an octahedral metal complex that can exist as 12 diastereomeric‐at‐metal isomers. Calculations reveal that 2 of 12 stereoisomeric complexes account for 99.9% of the Boltzmann population and that ...
Weijia Shen +6 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini +19 more
wiley +1 more source
The use of pyrimidine derivatives as adsorbents for the removal and extraction of heavy metal ions
Pyrimidine and pyrimidine derivatives, which are included in heterocyclic compounds, are used in various applications in fields such as pharmaceutical medicine, biochemistry, analytical chemistry, polymer chemistry, coordination chemistry, and ...
Çaylak, Osman, Tüzün, Burak
core
Arthritis &Rheumatology, EarlyView.Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven +6 more
wiley +1 more source