Results 121 to 130 of about 121,513 (263)

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Lactate-driven pyrimidine synthesis promotes ferroptosis resistance in hepatocellular carcinoma. [PDF]

Mol Biomed
Park MJ, Lee S, Kim DH, Kim MK, Jang BK, Yoon G, Park M, Jeong GH, Byun JK, Choi YK, Park KG.   +10 more
europepmc   +1 more source

A Dual‐Mode Photoconductive Colorimetric Wearable UV‐Dosimeter: Strategies for Tunable UV‐Band Sensitivity

Small, EarlyView.
The harmful ultraviolet component of sunlight necessitates reliable and wavelength‐selective personal UV monitoring technologies. Here, thermally evaporated CuBr thin films enable dual‐mode UV dosimetry through persistent photoconductive and colorimetric responses arising from charge trapping and surface oxide formation.
Suman Kundu, Aneeta Jaggernauth, Robert O'Connor, Rajani K. Vijayaraghavan   +3 more
wiley   +1 more source

A SMUG1 Inhibitor Modulates the Excision of Pyrimidine DNA Damage. [PDF]

ACS Med Chem Lett
Thacker PS, Gao Y, McPherson L, Lee A, Averill AM, Pratihar S, Doublié S, Ford JM, Kool ET.   +8 more
europepmc   +1 more source

Filtration‐Based SERS With In Situ Gold Growth in Bacterial Microenvironment for Rapid Detection of Low‐Level Bacteria

Small Methods, EarlyView.
A filtration‐assisted SERS platform integrating in situ gold growth within the bacterial microenvironment enables rapid and highly sensitive detection of low‐level bacteria in complex biological matrices. By overcoming hotspot–bacteria mismatch, the platform simultaneously achieves selective bacterial identification and rapid antimicrobial ...
Eun‐Bi Jang, Ji Young Lee, Hoeil Chung, Min‐Young Lee   +3 more
wiley   +1 more source

Synthesis, DNA-binding and antiproliferative activity of N-(Nitrogen heterocyclic) norcantharidin acylamide acid

Open Chemistry, 2009
Zhu Wen-Zhong, Hu Rui-Ding, Lin Qiu-Yue, Wang Xiao-Xia, Zheng Xiao-Liang   +4 more
doaj   +1 more source

The oncogenic control of nucleotide synthesis. [PDF]

Oncogenesis
Vidal-Cruchez O, Ben-Sahra I.
europepmc   +1 more source

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish

Integrative Zoology, EarlyView.
This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu, Li Sun, Jiao Chen, Jing Wang, Miao Guan, Shixia Xu   +5 more
wiley   +1 more source

A synergistic acid-base tandem co-sensitization approach using pyrimidine fluorescent dyes achieves 22% indoor efficiency. [PDF]

Sci Rep
Badawy SA, Shehta W, Masry AA, Moustafa AH, Elmorsy MR.   +4 more
europepmc   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source