Results 131 to 140 of about 161,675 (297)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

PhD

, 2008
dissertationThe antitumor activity shown by 2,4-dioxopyrido[2,3-d]pyrimidine (1), 4-oxopyrido[2,3-d]pyrimidine (2) and sangivamycin (17) stimulated the synthesis of the nucleoside derivatives, 2,4-dioxo-1-(beta-D-ribofuranosyl)pyrido[2,3-d]pyrimidine ...
Rizkalla, Boshra Hanna
core  

Dihydropyrimidine Dehydrogenase Genotype–Phenotype Correlations in Plasma and Peripheral Blood Mononuclear Cells

Clinical Pharmacology &Therapeutics, EarlyView.
The chemotherapeutic 5‐fluorouracil (5‐FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5‐FU toxicity.
Brianna M. Bembenek, Seid Hamzic, Kelly J. Bouchonville, Carlo R. Largiadèr, Steven M. Offer   +4 more
wiley   +1 more source

Sustainable Hydrogen Production by Glycerol and Monosaccharides Catalytic Acceptorless Dehydrogenation (AD) in Homogeneous Phase

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Sustainable hydrogen production can be obtained from hydogen‐rich biomass‐derived organic molecules through Acceptorless Dehydrogenation (AD) reactions. Glycerol and sugars are available in large quantities from industry and can be successfully used as substrates in AD protocols, in the presence of tailored, selective, easily tunable and thermally ...
Sylwia Kostera, Luca Gonsalvi
wiley   +1 more source

Design, synthesis, bioassay, and molecular docking of novel thiazolo[3,2-a]pyrimidine derivatives as insecticidal and antimicrobial agents. [PDF]

RSC Adv
Mohamed SA, Zaki RM, Danial AW, Kamal El-Dean AM, Saddik AA, Abd-Elnabi AD, Tolba MS, Fouad MR.   +7 more
europepmc   +1 more source

Synergistic Molecular Engineering and Crosslinking Topology for High‐Temperature Energy Storage in All‐Organic Dielectrics

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A synergistic strategy combining CF3 group incorporation and crosslinking topology is employed to tailor chain spacing and local ordering in all‐organic dielectrics. This design effectively suppresses carrier migration and enhances polarization, yielding outstanding high‐temperature energy storage performance (e.g., 8.95 J cm−3 with 90% efficiency at ...
Xu Tong, Xue Zhang, Tiandong Zhang, Changhai Zhang, Zhiqi Zhou, Tongqin Zhang, Jiaqi Zhang, Chao Wang, Yue Zhang, Yongquan Zhang, Qingguo Chi   +10 more
wiley   +1 more source

Characterization of carABpyrB operon and role of pyrE in Francisella novicida biofilm. [PDF]

Microbiologyopen
Sprinkel KC, Geiger AR, van Hoek ML.
europepmc   +1 more source

The Serendipitous Discovery of Rollover Cyclometalation: From Unrecognized Observation to Transformative Chemistry

European Journal of Inorganic Chemistry, EarlyView.
Rollover cyclometalation is a distinctive variant of classical cyclometalation where a chelated heterocyclic ligand undergoes internal rotation, releasing one donor atom from coordination and subsequently activating a remote C─H bond with high regioselectivity.
Antonio Zucca, Maria I. Pilo
wiley   +1 more source

Tandem Synthesis and Photophysical Behavior of Pyrazolo[3,4‐h][1,6]naphthyridines: A Theoretical–Experimental Approach

European Journal of Organic Chemistry, EarlyView.
A tandem reaction of 5‐aroylpyrazolo[3,4‐b]pyridines with malononitrile and methanol to access pyrazolo[3,4‐h][1,6]naphthyridines was achieved in 60%–66% yield under microwave conditions. The tricyclic fluorophoric core bears groups of different stereoelectronic nature (i.e., alkyl, aryl, MeO, and CN), and thus their optoelectronic activity shows ...
Carlos Cifuentes, Alexander Ladino‐Bejarano, Cristian Rivera‐Moyano, Jaime Portilla   +3 more
wiley   +1 more source

Stereodynamics of Hemiacetal Formation in Pyridine-3-Carbaldehyde and Pyrimidine-5-Carbaldehyde Derivatives: Implications for the Soai Reaction. [PDF]

Chirality
Möhler P, Siegle AF, Trapp O.
europepmc   +1 more source