Results 151 to 160 of about 147,452 (301)

Characterization of Gastrointestinal Absorption of Salmon Milt-Derived Oligodeoxyribonucleic Acids in Mice. [PDF]

J Nutr Metab
Hayashi F, Masuo Y, Nishizawa Y, Koike A, Ishimoto T, Kiriyama K, Fujita M, Sutoh K, Kato Y.   +8 more
europepmc   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

The antitumor promise of furo[2,3-<i>d</i>]pyrimidine: a 2016-2025 review. [PDF]

RSC Adv
Mansour MA, Elshafei HA, Sayed AS, Ashour AA, Hussein NE, Abdel Karim MM, Kamel FM, Elsayed NT, Ahmed MR, Seleem MT, Gomaa RM.   +10 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Genetic analysis of pyrimidine biosynthetic enzymes in Plasmodium falciparum. [PDF]

PLoS Pathog
Rajaram K, Sievert ML, Elahi R, Blauwkamp J, Dillard LB, Absalon S, Prigge ST.   +6 more
europepmc   +1 more source

Chemical Kinetics of 2‐, 4‐, and 2,4‐Seleno‐Uracils at Low Temperatures: Tautomerizations and Rotamerizations on Inert Matrices

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT In the interstellar medium, chemical reactions proceed under conditions vastly different to those on Earth; these include extremely low temperatures and densities and take place in the gas phase and on water–ice grains. Understanding the energetics and more importantly the kinetics of such reactions is of relevance to the consequences on how ...
Judith Wurmel, John M. Simmie
wiley   +1 more source

The arginine synthetase pathway is responsible for carbamoyl phosphate synthesis in <i>Thermococcus kodakarensis</i>. [PDF]

Front Microbiol
Michimori Y, Ohashi N, Szymanski C, Atomi H.   +3 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Sodium butyrate suppresses endometrial cancer cell growth by inhibiting thymidylate synthase and reprogramming pyrimidine metabolism. [PDF]

Genes Nutr
Kim N, Park S, Yang C.
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source