Results 151 to 160 of about 161,675 (297)

Pyrimidine-based NNRTIs in HIV therapy: advances in synthesis, potency and structure-activity relationships. [PDF]

RSC Adv
Ali H, Hashmi MA, Ajmal N, Goraija MS, Rasool N, Siddiqua UH, Malik A.   +6 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Pyrimidine and Purine Concentrations in Cord, Preterm and Term Infant Plasma Compared to Maternal Values-An Observational Study. [PDF]

Nutrients
Minarski M, Rottach-Barnekow F, Shunova A, Böckmann K, Bernhard W, Wiechers C, Poets CF, Franz AR.   +7 more
europepmc   +1 more source

Pyrimidine derivatives as anti-inflammatory agents

Although the discovery of a new drug is time-consuming and can cost billions of dollars, it is highly essential for improving patient outcomes with minimum toxicity.
Çetintaş, Halil Ibrahim, Tüzün, Burak   +1 more
core  

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Dual inhibitors of CDK2 and TRKA kinases: design, synthesis, antiproliferative activity and molecular modeling of novel pyrazolopyrimidine derivatives. [PDF]

RSC Adv
Attia MH, Lasheen DS, Samir N, Taher AT, Abdel-Aziz HA, Abou El Ella DA.   +5 more
europepmc   +1 more source

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

Journal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay, Cansu Topkaya, Elif Kağa, Yasin Eren, Ramazan Güp   +4 more
wiley   +1 more source

Synthesis, DNA-binding and antiproliferative activity of N-(Nitrogen heterocyclic) norcantharidin acylamide acid

Open Chemistry, 2009
Zhu Wen-Zhong, Hu Rui-Ding, Lin Qiu-Yue, Wang Xiao-Xia, Zheng Xiao-Liang   +4 more
doaj   +1 more source

Green Acid Mediated Synthesis of Imidazo[1,2-a]Pyrimidine-Thiazole/1,3,4-Thiadiazole Hybrids: Design, Characterization and In-Vitro Biological Evaluation. [PDF]

Chem Biodivers
P D, Naik S, D U, Dhekale MS, Vibhutimath SP, Rajula RR, B C R, Bhat N, Veeranagaiah NS.   +8 more
europepmc   +1 more source

Biochemical testing and pathology reveal rare cause of pediatric acute liver failure: Hyperornithinemia‐hyperammonemia‐homocitrullinuria syndrome

JPGN Reports, EarlyView.
Abstract Hyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome is a rare metabolic condition that can cause lethargy, ataxia, tachypnea, nausea, vomiting, seizures, coma, and acute liver failure. We present a 26‐month‐old female with acute liver failure who was diagnosed with HHH 1 week after admission. Histology revealed an acute hepatitic
Tierra L. Mosher, Kathryn S. Czepiel, Matthew B. Neu, Andrea Carolina Cortes Fernandez, L. Walden Browne, Annie D. Niehaus, Roberto Gugig   +6 more
wiley   +1 more source