Results 171 to 180 of about 251,884 (333)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Synthesis, antioxidant and antimicrobial activities, molecular docking study of new pyrimidine derivatives. [PDF]

Sci Rep
Khalaf HS, El-Rashedy AA, Abd El-Gwaad AA, Fayed AA.   +3 more
europepmc   +1 more source

Glycolysis and pyrimidine biosynthesis are required for replication of adherent–invasive Escherichia coli in macrophages

, 2016
A. Thompson, Ian O’Neill, Emma Jane Smith, John Catchpole, Ailís Fagan, Karl Burgess, Ruaidhrı́ J. Carmody, David J. Clarke   +7 more
openalex   +2 more sources

Pyrimidine base and ribonucleoside catabolic enzyme activities of thePseudomonas diminutagroup [PDF]

, 1992
Thomas P. West
openalex   +1 more source

Novel Pyrimidine-5-carboxamide Compounds as NNMT Inhibitors for Treating Diabetes

, 2021
Ram W. Sabnis
openalex   +2 more sources

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

The pyrimidine tracts of bacteriophage øX174

, 1969
Riva Pearl Wenig Bickel
openalex   +1 more source

Studies on Pyrimidine Derivatives. VII

, 1960
Kenzo Sirakawa
openalex   +2 more sources

A one step synthetic approach to L-pyrimidine nucleosides using Natural Phosphate coated with potassium iodide as catalyst [PDF]

, 2008
Hassan B. Lazrek, Laila Baddi, Driss Ouzebla, Michaël Smietana, Jean‐Jacques Vasseur   +4 more
openalex   +1 more source

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

Cancer Science, EarlyView.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen, Xin Li, Weixiong Zhu, Yanxi Mu, Guoqing Zhang, Youheng Zhang, Yusheng Cheng, Wence Zhou   +7 more
wiley   +1 more source