Results 191 to 200 of about 121,513 (263)

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source

Design, Synthesis and Antiviral Evaluation of Pyrido[1,2-<i>c</i>]pyrimidin-1-one Derivatives Against Porcine Epidemic Diarrhea Virus (PEDV). [PDF]

Molecules
Xu W, Ni W, Zhou Z, Ju Z, Liu S, Pan S, Jiang X.   +6 more
europepmc   +1 more source

Conjugated Linoleic Acid‐Enriched Fermented Dairy Modulates Microbiota and Metabolites to Alleviate MASLD: Insights From Multi‐Omics and Causal Mediation Analysis

Food Frontiers, Volume 7, Issue 5, September 2026.
In a 120‐day randomized trial, CLA‐enriched fermented dairy remodeled the gut microbiota and rewired host metabolic pathways in patients with MASLD. These changes were accompanied by reductions in ALT, total cholesterol, creatinine, and hs‐CRP, supporting a microbiota‐mediated dietary strategy for metabolic and liver health.
Fei Mi, Yanjiao Wang, Jia Xiong, Yiyuan Ma, Hongmei Pan, Jianzhong Yin, Yunmei Chai, Yao Wang, Xin Xu, Ai Zhang, Qingwen Ma, Hui Wang, Dongbai Liu, Shaoxiong Wu   +13 more
wiley   +1 more source

DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer. [PDF]

Cancer Res
Mao C, Wu S, Rajacharya GH, Wang M, Lu Z, Huo D, Yan Y, Chen X, Lei G, Xu Z, Li Q, Sun M, Zhao X, Zhuang L, Jiang D, Lin SH, Koong AC, Singh PK, Gan B.   +18 more
europepmc   +1 more source

Correction: Novel pyrimidine-substituted chalcones: In vitro antioxidant properties and cytotoxic effects against human cancer cell lines. [PDF]

PLoS One
Nayak P, Shenoy VS, Upadhye V, Abass KS, Alsaidan OA, Soni M, Hajare ST.   +6 more
europepmc   +1 more source

Dynamics of enzyme and metabolic profile of broilers fed black soldier fly (<i>Hermetiailucens</i>) larvae-based diets. [PDF]

Biochem Biophys Rep
Oladejo OA, Ibiwoye DO, Faniyi AA, Ayoola MO, Oguntunji AO, Ayansina AD, Dahunsi SO.   +6 more
europepmc   +1 more source

Myricetin Inhibits <i>Toxoplasma gondii</i> Growth, Alters Intracerebral Cyst Morphology, and Demonstrates Therapeutic Efficacy In Vivo. [PDF]

Cells
Ge CC, He HX, Pei MY, Tang SQ, He W, Bian MM, Pan M, Huang SY.   +7 more
europepmc   +1 more source

Synthesis and biological evaluation of <i>N</i>/<i>O</i>-propargylated diarylpyrimidines as dual inhibitors of acetylcholinesterase and monoamine oxidase. [PDF]

RSC Adv
Kumar N, Jangid K, Kumar V, Dwivedi AR, Kumar V, Devi B, Arora T, Parkash J, Kumar V.   +8 more
europepmc   +1 more source

Cross-Reactivity of Antiphospholipid Antibodies with Gut Commensal Proteins in Antiphospholipid Syndrome. [PDF]

TH Open
van Mourik DJM, Balvers M, Jansen VLBI, de Jonge PA, Coppens M, Nieuwdorp M, Middeldorp S, Eikenboom JCJ, Voorberg J, van Mens TE.   +9 more
europepmc   +1 more source

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Pyrimidines. XIII. Novel pyrimidine to pyrimidine transformation reactions

Journal of Heterocyclic Chemistry, 1977
AbstractNovel pyrimidine to pyrimidine transformation reactions are described. 1,3‐Dimethyl‐(or diethyl)‐uracil(1) are converted into isocytosine, 2‐thiouracil or uracil derivatives by treatment with guanidine, thiourea or urea, respectively. The latter two cases require base catalysis. The effects of some substituents at C‐5 and C‐6 of 1,3‐dialkylated
Kosaku Hirota, Kyoichi A. Watanabe, Jack J. Fox   +2 more
openaire   +1 more source