Results 211 to 220 of about 147,452 (301)

Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt-FoxO signaling. [PDF]

Front Immunol
Bian S, Zhao L, Wang X, Wu Z, Yang M, Ou J, Han T, Liao F, Xue Q, Huo X, Chang J.   +10 more
europepmc   +1 more source

The IKU2/RLK7–MAPK–MINI3 signaling module controls endosperm cellularization timing to determine seed size in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The phosphorylation status of the WRKY transcription factor WRKY10/MINI3, controls the timing of endosperm cellularization in Arabiopsis, thus regulating final seed size, offering a molecular understanding that could inform future agricultural breeding strategies. ABSTRACT Seed size is a critical factor in determining crop yield.
Min Ni, Yuchen Qian, Tinggang Nong, Wangshu Mou, Niu Liu, La Yang, Dongdong Li, Huixia Shou, Juan Xu   +8 more
wiley   +1 more source

Correction for Pfannenstiel et al., "Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication". [PDF]

mBio
Pfannenstiel JJ, Duong MTH, Cluff D, Sherrill LM, Colquhoun I, Cadoux G, Thorne D, Pääkkönen J, Schemmel NF, O'Connor J, Saenjamsai P, Feng M, Parthasarathy S, Hageman MJ, Johnson DK, Roy A, Lehtiö L, Ferraris DV, Fehr AR.   +18 more
europepmc   +1 more source

Asthma in Young Adults at High Risk for Allergies Is Traced Back to Immune and Microbiota Signatures in Early Childhood

Clinical &Experimental Allergy, EarlyView.
Ymke A. de Jong, Isabella Badolati, Ulrika Hellberg, Katarína Bankóová, Caroline Nilsson, Eva Sverremark‐Ekström   +5 more
wiley   +1 more source

Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance

New Phytologist, EarlyView.
Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap, Arash Fazeli, Ali Bandehagh, Nicolas L. Taylor   +3 more
wiley   +1 more source

Evaluating 7‑Aminopyrazolo[4,3‑<i>d</i>]pyrimidines as Human A₁ and A₃ Adenosine Receptor Antagonists. [PDF]

ACS Omega
Georgiou K, Lamprakopoulou M, Buthmann H, Böing S, Pousias A, Dexter A, Chew EXY, Huang X, Michalettou EI, Pearce A, Dotsikas Y, Pouli N, Marakos P, Kolocouris A, Ladds G, Lougiakis N.   +15 more
europepmc   +1 more source

Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa

Oral Diseases, EarlyView.
ABSTRACT Objective To analyze the nuclear abnormalities of cytotoxicity—karyorrhexis (KR), karyolysis (KL), and pyknosis (PN)—and genotoxicity—micronucleus (MN) in exfoliated cells from different sites of the oral mucosa in patients with Epidermolysis Bullosa (EB) and a control group.
Ana Carolina Sias Franco Franzosi, Rebeca Ferreira Badaró, Lucas Fernandes Leal, Rosalie Matuk Fuentes Torrelio, Willian Grassi Bautz, Leticia Nogueira da Gama‐de‐Souza   +5 more
wiley   +1 more source

Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer. [PDF]

Nat Commun
Nan Y, Wang K, Hu M, Luo Q, Wu X, Yu X, Zhou X, Chen L, Li B, Cui Z, Liu Z.   +10 more
europepmc   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, EarlyView.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Megamitochondria in alcohol-associated liver disease and cancer: a friend or foe? [PDF]

eGastroenterology
Niu M, Wei X, Ma X, Ding WX.
europepmc   +1 more source