Results 211 to 220 of about 161,675 (297)

Author response to Commentary on "Long-term safety and efficacy of deoxycytidine/deoxythymidine in treatment of POLG-related disorders". [PDF]

Neurotherapeutics
Myers KA, Buhas D, Waters PJ.
europepmc   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

A deep eutectic solvent mediated synthesis of spiro[naphthalene-2,5'-pyrimidine]-4-carbonitriles and their <i>in silico</i> inhibitory potential against the SARS-CoV-2 main protease. [PDF]

RSC Adv
Chaudhary A, Saluja P, Mathur D, Yadav S.   +3 more
europepmc   +1 more source

Toward “Obesityomics”: Domain‐Specific Omics in Precision Obesity Medicine with a Brief AI Perspective

Obesity Reviews, EarlyView.
ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra, Sara G. I. Suliman, Mohammed Al‐Hadad, Dorret I. Boomsma, Fadwa Alhantoobi, Maithah Alsamahi, Haneen Abufarajallah, Alia Al Tikriti, Zeyar Aung, Selena Richards, Abdulrahim Sajini, Mira Mousa, Fatima Sulaiman, Wael Osman   +13 more
wiley   +1 more source

Retraction Note: Synthesis, antimicrobial, anti-inflammatory, antioxidant and cytotoxicity of new pyrimidine and pyrimidopyrimidine derivatives. [PDF]

Sci Rep
Keshk RM, Salama ZA, Elsaedany SK, ElRehim EMA, Beltagy DM.   +4 more
europepmc   +1 more source

Molecular Links Between Heat Stress and DNA Damage Response in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT Climate change poses a major threat to agricultural productivity and, consequently, to global food security. Among the consequences of climate change, heat stress (HS) has emerged as a critical factor limiting crop performance. This has stimulated extensive research over the past decade to elucidate the molecular and physiological mechanisms ...
Adrian Calves‐Ubach, Miriam Szurman‐Zubrzycka   +1 more
wiley   +1 more source

Design, synthesis, molecular docking and molecular dynamics simulations of pyrazolo[3,4-<i>d</i>]pyrimidine scaffolds as selective COX-2 and CDK2 kinase inhibitors with dual anti-inflammatory and anti-proliferative activities. [PDF]

RSC Adv
Ewieda SY, Ziko L, Elshewy A, Salem M, Ibrahim ML, Lotfy Khaled M, Abdalla M, Eltayb WA, Elnagar MR, Tawfik MM, Abdullah Alzahrani AY, Nemr MTM.   +11 more
europepmc   +1 more source

Epigenetic signatures of attention problems in youth with childhood exposure to family and community violence

Psychiatry and Clinical Neurosciences, EarlyView.
Aim The link between violence‐related epigenetic changes and attentional problems (APs) is still not well understood. This article examines if exposure to family and community violence during childhood and adolescence may shape DNA methylation patterns associated with attention in youth.
Renata Queiroz Ramos, Adriane Feijó Evangelista, Cosme Marcelo Furtado Passos da Silva, Fernanda Serpeloni, Joviana Quintes Avanci, Natasha Reis Lacerda, Simone Gonçalves de Assis   +6 more
wiley   +1 more source

Drugs inducing interstitial lung disease: in silico analysis of their structures and targets. [PDF]

Mol Med
Tanabe M, Takahama S, Yamamoto T, Sakate R.   +3 more
europepmc   +1 more source