Results 231 to 240 of about 251,884 (333)

Interventional human ocular safety experiments for 222‐nm far‐ultraviolet‐C lamp irradiation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 517-526, March/April 2025.
To directly assess the ocular safety of 222‐nm far‐ultraviolet‐C (UVC) irradiation in humans, five subjects were exposed to 222‐nm UVC at doses of 22, 50, and 75 mJ/cm2. The findings indicate that far‐UVC irradiation does not cause “clinically significant photokeratitis” or long‐term ocular damage, though it may induce temporary discomfort.
Kazunobu Sugihara, Sachiko Kaidzu, Masahiro Sasaki, Masaki Tanito   +3 more
wiley   +1 more source

On the ozonation of anti-SARS-CoV-2 substances and their nucleoside analogues for mechanistic understanding of the ozone induced transformation using HPLC-ESI-Q-TOF-HRMS. [PDF]

RSC Adv
Bartels I, Hoffmann-Jacobsen K, Schmidt TC, Jaeger M.   +3 more
europepmc   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Fe₃O₄@SiO₂@taurine: a magnetically recoverable green nanocatalyst for efficient synthesis of pyrano[2,3-<i>d</i>]pyrimidine derivatives. [PDF]

Nanoscale Adv
Paliwal C, Aanchal, Dharmendra, Ranawat PS, Ameta KL, Ameta C.   +5 more
europepmc   +1 more source

Alloxazine derivatives as multifunctional agents for photodynamic therapy, cancer cell imaging, and cell proliferation inhibition

Photochemistry and Photobiology, EarlyView.
Alloxazine photosensitizers, molecularly engineered through sugar conjugation and methoxy substitution to enhance solubility, photodynamic potency, and fluorescence, enable image‐guided photodynamic therapy while inhibiting cancer cell growth in the absence of photoactivation.
Rubej R. Khan, Sourav Kanti Seth, Reshma Mathew, Nitza V. Falcón‐Cruz, Chris Acquah, Steffen Jockusch, Liraz Levi, Carlos E. Crespo‐Hernández   +7 more
wiley   +1 more source

Acetylated Pyrimidine Metabolism Genes as Prognostic Markers and Their Influence on Immune Profiles in Lung Adenocarcinoma. [PDF]

Hum Mutat
Jia K, Zhang S, He Y, Liang L, Nair S.
europepmc   +1 more source

Investigation of 222‐nm ultraviolet C irradiation bactericidal effect on the surgical field in a rabbit model

Photochemistry and Photobiology, EarlyView.
In a rabbit surgical field model seeded with polymicrobial flora, a single dose of 222‐nm UV‐C (500 mJ/cm2) markedly reduced bacterial colonies, achieving a bactericidal effect comparable to 254‐nm UV‐C (200 mJ/cm2), while no UV‐C irradiation showed heavy growth. Wound healing did not differ among groups. Microbiota profiling detected SSI‐relevant taxa
Tomoaki Fukui, Yuya Yamamoto, Kyohei Takase, Keisuke Oe, Kenichi Sawauchi, Ryota Nishida, Takahiro Niikura, Rena Kaigome, Masahiro Sasaki, Toru Koi, Hiroyuki Ohashi, Ryosuke Kuroda   +11 more
wiley   +1 more source

Benzoyl Ring Halogenated Classical 2-Amino-6-methyl-3,4-dihydro-4-oxo-5-substituted Thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine Antifolates as Inhibitors of Thymidylate Synthase and as Antitumor Agents

, 2004
Aleem Gangjee, Hiteshkumar D. Jain, John J. McGuire, Roy L. Kisliuk   +3 more
openalex   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Pyrimidine-based compounds as promising anticancer agents targeting tumor cell senescence. [PDF]

Mol Ther Oncol
Carpintero-Fernández P, Martínez MM, Carneiro-Figueira A, Martínez R, García-Yuste A, Barturen-Gómez M, Pérez-Caaveiro C, Guitián-Caamaño A, Sarandeses LA, Sestelo JP, Mayán MD.   +10 more
europepmc   +1 more source