Results 111 to 120 of about 161,675 (297)
Synthesis of аlkenyloxy(аміnо)pyrazolo[3,4-D]pyrimidine-4-ones
, 2014 Alkenyl ethers regioselectively synthesized pyrazolo [3,4-d] pyrimidine-4-one, did not make a direct alkylation of pyrazolo [3,4-d] pyrimidine-4,6-dione.
Свалявин, Н. І. +4 more
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Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry
Bulletin of the Korean Chemical Society, EarlyView.Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah +8 more
wiley +1 more source
Advanced ScienceMetabolic abnormalities contribute to the pathogenesis of obesity and its complications. Yet, the understanding of the interactions between critical metabolic pathways that underlie obesity remains to be improved, in part owing to the lack of ...
Huiying Liu +9 more
doaj +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
Photodimerization in pyrimidine-substituted dipeptides
, 2005 Ten N-epsilon-glycylornithineamide derivatives have been synthesized containing various N-alpha-linked pyrimidine-1-ylacetyl groups which can undergo (2 pi + 2 pi) photodimerization on irradiation with UV light at 254 rim.
Ramanujam, P.S. +3 more
core +1 more source
Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly
Bulletin of the Korean Chemical Society, EarlyView.Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim +7 more
wiley +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Purification and properties of bacterial pyrimidine nucleosidase
, 1951 The metabolism of pyrimidine nucleosides was found to be similar to the dissimilation of purine nucleosides. Thus pyrimidine base is cleaved from the nucleoside and is accumulated.
Paege, Lynn
core +1 more source
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
Elevated Expression of Pyrimidine Nucleoside Phosphorylase (PyNPase) in Renal Cell Carcinoma Tissue [PDF]
, 2001 Background: Pyrimidine nucleoside phosphorylase (PyNPase) is an enzyme that converts 5'-deoxy-5-fluorouridine to 5- fluorouracil. PyNPase is identical to platelet-derived endothelial cell growth factor (PD-ECGF), and has angiogenic activity.
Maeda, Kanenori +4 more
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