Results 271 to 280 of about 251,884 (333)

Synthesis and antitumor property of triazole-aryloxyacetyl hydrazide hybrids with furo[2,3-d]pyrimidine scaffold. [PDF]

BMC Chem
Ma J, Zhao W, Gao H, Zhang B, Feng C, Hu Y.   +5 more
europepmc   +1 more source

Synthesis and Biological Evaluation of Imidazothiadiazole-Fused-Pyrimidine Derivatives as Anticancer Agents

G. Purna Chander Rao, Somaiah Nalla, V. Ramesh, D. Ramachandran, A. Kalyan Chakravarthy   +4 more
openalex   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Integrating network pharmacology, microbiomics, and metabolomics to uncover the therapeutic effect of Liubao tea on osteoarthritis. [PDF]

Front Immunol
Le G, Wen R, Huang Z, Fang H, Zheng J, Wang Y, Luo H.   +6 more
europepmc   +1 more source

Impact of Underlying Liver Disease on the Risk and Prognostic Factors of Breast Cancer Liver Metastases: A Retrospective Multicenter Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective To examine factors influencing breast cancer liver metastases (BCLM) and assess the impact of underlying liver diseases (nonalcoholic fatty liver and HBsAg infection) on BCLM development. Methods Patients diagnosed with breast cancer at four affiliated hospitals in China between 2014 and 2024 were included.
Xiaowen Wang, Yuan Zhang, Qiwei Yang, Luo Yang, Yanhui Wang, Xiangxin Zeng, Long Zou, Yujuan Guo, Wenyang Zhou, Yuqi Jiang, Jiezhong Wu, Peng Zhang, Song Zhou, Guangjuan Zheng, Tao Huang, Genshu Wang, Kunpeng Hu   +16 more
wiley   +1 more source

Design, Synthesis, and Antibacterial Evaluation of Pyrido[2,3‑<i>d</i>]Pyrimidine and Pyrido[3,2‑<i>e</i>]Pyrimido[1,2‑<i>c</i>]Pyrimidine Derivatives. [PDF]

ACS Omega
El-Essawy FA, Odah MAA.
europepmc   +1 more source

Combining drugs that bypass p53 to treat TP53-mutated leukemias. [PDF]

Blood Adv
Biswas S, Zahran ZAM, Gu X, Cardone L, Marti R, Mouannes N, Stich M, Jain A, Fedorov K, Tomlinson B, Goldfinger M, Verma A, Saunthararajah Y.   +12 more
europepmc   +1 more source

Identification of TgENT1 as the TgUUT1 Uracil/Uridine Transporter of <i>Toxoplasma gondii</i>. [PDF]

Pathogens
Elati HAA, Ferreira Silva M, Sheiner L, de Koning HP.   +3 more
europepmc   +1 more source

Disclosing New Insights on Pyrazolo[3,4-<i>d</i>] Pyrimidine Tethered Diverse Amino Acid Candidates as Potential DHFR Inhibitors and Anti-Virulence Agents. [PDF]

J Microbiol Biotechnol
Ibrahim TS, Salem IM, Alhakamy NA, Al-Mahmoudy AMM, Hegazy WAH.   +4 more
europepmc   +1 more source