Results 191 to 200 of about 16,097 (238)
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Repair of DNA‐containing pyrimidine dimers
The FASEB Journal, 1988Ultraviolet light‐induced pyrimidine dimers in DNA are recognized and repaired by a number of unique cellular surveillance systems. The most direct biochemical mechanism responding to this kind of geno‐toxicity involves direct photoreversal by flavin enzymes that specifically monomerize pyrimidine:pyrimidine dimers monophotonically
L, Grossman +3 more
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Nature, 1980
Pyrimidine dimer formation in response to UV radiation is governed by the thymine content of the potential dimer and the two flanking nucleotides. An enzymatic activity can be purified from Micrococcus luteus that cleaves the N-glycosyl bond between the 5' pyrimidine of a dimer and the corresponding sugar without rupture of a phosphodiester bond.
W A, Haseltine +5 more
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Pyrimidine dimer formation in response to UV radiation is governed by the thymine content of the potential dimer and the two flanking nucleotides. An enzymatic activity can be purified from Micrococcus luteus that cleaves the N-glycosyl bond between the 5' pyrimidine of a dimer and the corresponding sugar without rupture of a phosphodiester bond.
W A, Haseltine +5 more
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Pyrimidine dimer splitting in covalently linked dimer—arylamine systems
Journal of Photochemistry and Photobiology B: Biology, 1992Cyclobutadipyrimidines (pyrimidine dimers) undergo photosplitting which is sensitized by electron donors. We prepared a series of compounds in which a dimer is directly linked to an arylamine, which acts as sensitizer for dimer splitting. Two diastereomers of the dimer-arylamine exhibited very different splitting efficiencies.
S T, Kim, S D, Rose
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Electrochemically induced pyrimidine dimerization
Bioelectrochemistry and Bioenergetics, 1974Abstract A study has been made of the polarographic behaviour and the mechanisms of electroreduction of N-methyl derivatives of pyrimidone-2 and 4-methylthiouracils. One of the major electroreduction products of all the foregoing is a 6,6′-bis(3,6-dihydro-pyrimidone-2) dimer similar to that previously described as the major reduction product of the ...
Barbara Czochralska +2 more
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Are pyrimidine dimers Non-Instructive lesions?
Molecular and General Genetics MGG, 1981Published data from yeast and E. coli show that base substitution induced by UV in pyrimidine-pyrimidine sequences is not random, and suggest that fidelity of DNA replication is not entirely lost during transdimer synthesis. These observations question whether cyclobutane pyrimidine dimers are truly non-instructive lesions.
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Pyrimidine Dimers: Effect of Temperature on Photoinduction
Science, 1966Ultraviolet-induced pyrimidine dimer formation in DNA and polyuridylic acid was inhibited on irradiation at 77°K. Enhancement of thymine dimer formation in solutions of DNA occurred upon addition of ethylene glycol. Low temperature measurements of absorbance of polyuridylic acid at low temperature showed that no significant alteration of the residues ...
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On the pyrazine and pyrazine–pyrimidine dimers
The Journal of Chemical Physics, 1986Spectra of the pyrazine-d4, pyrazine-h4–pyrazine-d4, and pyrazine-d4–pyrimidine dimer are obtained and analyzed with the help of Lennard-Jones–hydrogen-bonding (LJ–HB) potential energy calculations. The pyrazine isotopic hetero and homo dimers possess nearly identical spectra with the exception that the perpendicular dimer features are displaced to the
J. Wanna, E. R. Bernstein
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Production of pyrimidine dimers in DNA in the dark
Biochemical and Biophysical Research Communications, 1971Abstract Trimethyl-1,2-dioxetane was decomposed (70°C) in the presence of E.coli DNA. Pyrimidine dimers were detected in the hydrolysate of the reaction mixture. Assuming the existence in cells of reactions which produce electronically excited molecules of sufficient energy these results demonstrate the possibility that pyrimidine photodimers ...
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Mechanism of photosensitized dimerization of pyrimidines
Chemical Communications (London), 1968Excited sensiter molecule in triplet state interacting with the target molecule (thymine) tranfers its triplet state energy to the latter. Two excited target molecule dimerize.
Kornhauser, Andrija +2 more
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The role of pyrimidine dimers in postreplication repair in Neurospora
Molecular and General Genetics MGG, 1982Using the Micrococcus luteus dimer specific endonuclease assay of Wilkins (1973), and photoreactivation we have examined the induction and fate of ultraviolet induced pyrimidine dimers in the excision defective strain, uvs-2, of Neurospora crassa. Dimer induction was fluence dependent from 0 to 800 ergs/mm2 UV.
R E, Calza, A L, Schroeder
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