Results 41 to 50 of about 15,307 (218)
Food Safety and Health, EarlyView.Although fresh produce is extremely perishable and contaminated, it is essential for good health. To eliminate important foodborne pathogens, this paper investigates UV‐C irradiation as a safe, nonthermal technique. UV dose, exposure duration, and product characteristics all affect effectiveness.
Krish Rauniyar, Ruplal Choudhary
wiley +1 more source
5-Propyl-6-(p-tolylsulfanyl)pyrimidine-2,4(1H,3H)-dione
Acta Crystallographica Section E, 2014 In the title pymiridine-2,4-dione derivative, C14H16N2O2S, the dihedral angle between the six-membered rings is 66.69 (10)°. The molecule is twisted about the Cp—S (p = pyrimidine) bond, with a C—S—C—N torsion angle of −19.57 (16)°.
Fatmah A. M. Al-Omary +4 more
doaj +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair
Nature Communications, 2017 Repair of cyclobutane pyrimidine dimers requires access to DNA by the nucleotide excision repair machinery. Here the authors show that HBO1 facilitates accumulation of SNF2H and ACF1 to make chromatin more accessible after ultraviolet damage.
Hiroyuki Niida +14 more
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4-{4-Methyl-2-[(methyl)(2-methylphenyl)amino]-1,3-thiazol-5-yl}-N-(3-methylphenyl)pyrimidin-2-amine
Acta Crystallographica Section E, 2011 In the title compound, C23H23N5S, the thiazole ring and pyrimidine ring are almost coplanar, making a dihedral angle of 4.02 (9)°.
Hai-Bo Shi +3 more
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source
Acta Crystallographica Section E, 2011 In the title compound, C22H19Cl2N5S, the thiazole and pyrimidine rings are almost co-planar, making a dihedral angle of 6.48 (7)°.
Hai-Bo Li, Hai-Bo Shi, Wei-Xiao Hu
doaj +1 more source
Pyrimidine Dimers Block Simian Virus 40 Replication Forks [PDF]
Molecular and Cellular Biology, 1986 UV light produces lesions, predominantly pyrimidine dimers, which inhibit DNA replication in mammalian cells. The mechanism of inhibition is controversial: is synthesis of a daughter strand halted at a lesion while the replication fork moves on and reinitiates downstream, or is fork progression itself blocked for some time at the site of a lesion?
C A, Berger, H J, Edenberg
openaire +2 more sources
Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu +4 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source