Results 61 to 70 of about 14,504 (194)

Methyl 4-[(pyrimidin-2-yl)carbamoyl]benzoate

Acta Crystallographica Section E, 2011
Molecules of the title compound, C13H11N3O3, are connected into centrosymmetric dimers via intermolecular N—H...N hydrogen bonds, generating an R22(8) motif.
Chun-Hsiang Lu, Chia-Jun Wu, Chun-Wei Yeh, Hui-Ling Hu, Jhy-Der Chen   +4 more
doaj   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

5-[(4-Ethoxyanilino)methyl]-N-(2-fluorophenyl)-6-methyl-2-phenylpyrimidin-4-amine

Acta Crystallographica Section E, 2012
The asymmetric unit of the title compound, C26H25FN4O, consists of two symmetry-independent molecules, denoted A and B. The conformation of each molecule is mainly determined by an intramolecular N—H...N hydrogen bond, which closes a six ...
Jerzy Cieplik, Marcin Stolarczyk, Iwona Bryndal, Tadeusz Lis   +3 more
doaj   +1 more source

Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV‐induced skin damage

Photochemistry and Photobiology, Volume 101, Issue 2, Page 338-349, March/April 2025.
In the present work with mouse models, we demonstrate that a novel compound, NEO400, is able to profoundly protect skin against damage caused by UV radiation (UVR) when it is applied to skin post‐UVR exposure. In comparison, Aloe vera or linoleic acid are unable to achieve a similar level of protection.
Stephen Swenson, Catalina Silva‐Hirschberg, Liliana Freeland, Kristen L. Chen, Nagore I. Marín‐Ramos, Axel H. Schönthal, Thomas C. Chen   +6 more
wiley   +1 more source

Ethyl 2-(4-carboxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate–N,N-dimethylformamide (1/1)

Acta Crystallographica Section E, 2012
In the title compound, C24H20N2O5S·C3H7NO, a benzene ring is positioned axially to the pyrimidine ring, which adopts a twist-boat conformation, and is inclined to its mean plane by 85.36 (7)°.
Noor Afshan Banu, V. Bheema Raju
doaj   +1 more source

Interventional human ocular safety experiments for 222‐nm far‐ultraviolet‐C lamp irradiation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 517-526, March/April 2025.
To directly assess the ocular safety of 222‐nm far‐ultraviolet‐C (UVC) irradiation in humans, five subjects were exposed to 222‐nm UVC at doses of 22, 50, and 75 mJ/cm2. The findings indicate that far‐UVC irradiation does not cause “clinically significant photokeratitis” or long‐term ocular damage, though it may induce temporary discomfort.
Kazunobu Sugihara, Sachiko Kaidzu, Masahiro Sasaki, Masaki Tanito   +3 more
wiley   +1 more source

Synthesis and crystal structure of N-(4-chlorophenyl)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-amine

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, C13H12ClN5, was synthesized by the cyclization of 1-(4,6-dimethylpyrimidin-2-yl)-4-phenylthiosemicarbazide in the presence of Ni(NO3)2. The molecular structure of the compound is essentially planar.
Hlib Repich, Svitlana Orysyk, Pavlo Savytskyi, Vasyl Pekhnyo   +3 more
doaj   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

6-(3,5-Dimethoxybenzylamino)-9-(oxan-2-yl)-9H-purine

Acta Crystallographica Section E, 2013
The molecule of the title compound, C19H23N5O3, contains six-membered pyrimidine and five-membered imidazole rings merged into the essentially planar purine skeleton (r.m.s. deviation = 0.01 Å).
Pavel Štarha, Igor Popa, Zdeněk Dvořák, Zdeněk Trávníček   +3 more
doaj   +1 more source

Photoprotective potential of gadusol against ultraviolet B radiation in melanocytes

Photochemistry and Photobiology, EarlyView.
Gadusol protects melanocytes from ultraviolet B (UVB)‐induced damage without cytotoxicity. Abstract The increasing incidence of skin cancer, including melanoma, combined with the need for ultraviolet (UV) filters that are safe for human health and marine ecosystems, is driving the search for new photoprotective agents.
Andressa Mai Matsumoto, Rocío Isla Naveira, Andy Joel Taipe Huisa, Marcelo Augusto Germani Marinho, Lais Zortéa, José María Monserrat, Agueda Elena Massa, María Sandra Churio, Ana Paula de Souza Votto   +8 more
wiley   +1 more source