Results 91 to 100 of about 22,404 (220)

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, Volume 36, Issue 34, 27 April 2026.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Syntheses of Isoxazoline-Carbocyclic Nucleosides and Their Antiviral Evaluation: A Standard Protocol

The Scientific World Journal, 2014
The current synthesis of racemic purine and pyrimidine isoxazoline-carbocyclic nucleosides is reported, detailing the key-steps for standard and reliable preparations.
Paolo Quadrelli, Naiara Vazquez Martinez, Roberto Scrocchi, Antonino Corsaro, Venerando Pistarà   +4 more
doaj   +1 more source

Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites.

PLoS Neglected Tropical Diseases, 2020
Trypanosoma cruzi parasites utilise de novo pyrimidine biosynthesis to produce DNA and survive within mammalian host cells. This pathway can be hijacked to assess the replication of intracellular parasites with the exogenous addition of a DNA specific ...
Melissa Louise Sykes, David Hugh Hilko, Livia Isabella Kung, Sally-Ann Poulsen, Vicky Marie Avery   +4 more
doaj   +1 more source

Orotic Aciduria [PDF]

, 2018
Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core   +1 more source

Metarhizium anisopliae Mitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Inhibition of adenovirus serotype 14 infection by octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- nucleosides in vitro. [PDF]

, 2018
On September 22, 2008, a physician on Prince of Wales Island, Alaska, notified the Alaska Department of Health and Social Services (ADHSS) of an unusually high number of adult patients with recently diagnosed pneumonia (n = 10), including three persons ...
Barnard, Dale L, Beadle, James R, Hostetler, Karl Y, Kumaki, Yohichi, Mclean, Tyler Z, Roth, Jason P, Smee, Donald F, Valiaeva, Nadejda, Woolcott, John D   +8 more
core  

Aromatic N versus aromatic F : bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs [PDF]

, 2010
The thermodynamics of base pairing is of fundamental importance. Fluorinated base analogs are valuable tools for investigating pairing interactions. To understand the influence of direct base–base interactions in relation to the role of water, pairing ...
Alrun N. Koller, Jelena Božilović, Joachim W. Engels, Holger Gohlke, Schweitzer, Loakes, Parsch, Lai, Somoza, Murray-Rust, Dunitz, Dunitz, Kool, O'H, Olsen, Olsen, Olsen, Müller, Thalladi, Desiraju, Reichenbächer, Kopitz, Turner, Stofer, Freier, Turner, Tanner, Kierzek, Vesnaver, Levitt, Arora, Cubero, Meyer, Ryjácek, Cubero, Florian, Bats, Živković, Klöpffer, Živković, Bégué, Bayly, Cornell, Müller, Torrie, Case, Šponer, Šponer, Šponer, Jorgensen, Berendsen, Ryckaert, Darden, Bouzida, Efron, MacCallum, Varani, Buckin, Gao, Kool, Šponer, Barsky, Zacharias, Ran, Smart, Jeffrey, Bondi, Hof, Jakobi, Eritja, Parsch, Vorbrüggen, Furneaux, Rolland, Guckian   +74 more
core   +1 more source

Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells in vitro [PDF]

, 2016
A novel anti-tumor agent 4-thio-5-(2′′-thienyl)uridine (6) was synthesized and the in vitro cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells (HT-29) was evaluated by MTT assay.
Li, Depeng, Ma, Kedong, Qin, Jianzhong, Xu, Yaozhong, Zhang, Xiaohui   +4 more
core   +1 more source

Oxetanes: Recent Advances in Synthesis, Reactivity and Medicinal Chemistry [PDF]

, 2016
The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate.
Bull, JA, Croft, RA, Davis, OA, Doran, R, Morgan, KF   +4 more
core   +1 more source