Nucleoside Analogues as Antibacterial Agents [PDF]
Frontiers in Microbiology, 2019 The rapid increase in antibiotic-resistant bacteria has emphasized the urgent need to identify new treatments for bacterial infections. One attractive approach, reducing the need for expensive and time-consuming clinical trials, is to repurpose existing ...
Jessica M. Thomson, Iain L. Lamont
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Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]
Molecules, 2020 The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Heba Yehia +9 more
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In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues [PDF]
Scientific Reports, 2023 Drug-resistant Plasmodium falciparum (Pf) infections are a major burden on the population and the healthcare system. The establishment of Pf resistance to most existing antimalarial therapies has complicated the problem, and the emergence of resistance ...
Miklós Bege +9 more
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Checkpoint-Dependent Sensitivities to Nucleoside Analogues Uncover Specific Patterns of Genomic Instability [PDF]
Current Issues in Molecular BiologyNucleoside analogues are used as drugs and as labels in laboratory-based research. However, the effect of different nucleoside analogue mechanism(s) on cell sensitivity or mutagenesis is unclear.
Zainab Burhanuddin Kagalwala +5 more
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Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2023 Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside analogues have been widely used as anticancer drugs for the treatment of a variety of conditions, including gastrointestinal malignancies.
Xingxing Xu +4 more
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4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei [PDF]
Microorganisms, 2021 Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to synthesize purines de novo and thus solely depend on purine salvage from the host environment.
Dorien Mabille +10 more
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Nucleoside analogues for the treatment of animal trypanosomiasis [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2022 Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleosides
Dorien Mabille +9 more
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Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues [PDF]
Molecules, 2021 Despite the fact that COVID-19 vaccines are already available on the market, there have not been any effective FDA-approved drugs to treat this disease.
Vasiliki Daikopoulou +5 more
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Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches [PDF]
Molecules, 2022 Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is a serious public health problem. Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious efficacy and safety drawbacks.
Ludmila F. de A. Fiuza +10 more
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Nucleoside Analogues for Chagas Disease and Leishmaniasis Therapy: Current Status and Future Perspectives [PDF]
MoleculesChagas disease and leishmaniasis are two neglected tropical diseases that affect millions of people in low- and middle-income tropical countries. These diseases caused by protozoan parasites pose significant global health challenges, which have been ...
Emmanuel Awucha Nwoke +4 more
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