Results 11 to 20 of about 42,345 (197)
Broad-Spectrum Antiviral Strategies and Nucleoside Analogues [PDF]
Viruses, 2021 The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus 1 and 2 (SARS and SARS-CoV-2) viruses, or new strains of ...
Robert J. Geraghty +2 more
doaj +4 more sources
Current prodrug strategies for improving oral absorption of nucleoside analogues
Asian Journal of Pharmaceutical Sciences, 2014 Nucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired immunodeficiency disease syndrome), cytomegalovirus infections, cancer, etc. However, many nucleoside analogues exhibit poor oral bioavailability because of their
Youxi Zhang +3 more
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Synthetic strategies toward 1,3-oxathiolane nucleoside analogues [PDF]
Beilstein Journal of Organic Chemistry, 2021 Sugar-modified nucleosides have gained considerable attention in the scientific community, either for use as molecular probes or as therapeutic agents. When the methylene group of the ribose ring is replaced with a sulfur atom at the 3’-position, these ...
Umesh P. Aher +3 more
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6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2021 Kinetoplastid parasites are the causative agents of Chagas disease (CD), leishmaniasis and human African trypanosomiasis (HAT). Despite a sustained decrease in the number of HAT cases, more efforts are needed to discover safe and effective therapies ...
Cai Lin +6 more
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Aminoribosylated Analogues of Muraymycin Nucleoside Antibiotics [PDF]
Molecules, 2018 Nucleoside antibiotics are uridine-derived natural products that inhibit the bacterial membrane protein MraY. MraY is a key enzyme in the membrane-associated intracellular stages of peptidoglycan biosynthesis and therefore considered to be a promising ...
Daniel Wiegmann +2 more
doaj +3 more sources
Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues
Chemical Reviews, 2010 Peer ...
ROMEO G +3 more
openaire +6 more sources
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. [PDF]
Nature, 2022 Schultz DC +21 more
europepmc +2 more sources
Molecules, 2022 Pyrimidine nucleoside analogues are widely used to treat infections caused by the human immunodeficiency virus (HIV) and DNA viruses from the herpes family. It has been shown that 5-substituted uracil derivatives can inhibit HIV-1, herpes family viruses,
Vasily A. Kezin +7 more
doaj +1 more source
Enhanced Remdesivir Analogues to Target SARS-CoV-2
Molecules, 2023 We report the short synthesis of novel C-nucleoside Remdesivir analogues, their cytotoxicity and an in vitro evaluation against SARS-CoV-2 (CoV2). The described compounds are nucleoside analogues bearing a nitrogen heterocycle as purine analogues.
Ryuichi Majima +4 more
doaj +1 more source
Nucleoside Analogues and Mitochondrial Toxicity [PDF]
Clinical Infectious Diseases, 2004 An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity ...
Russell, Fleischer +2 more
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