Results 81 to 90 of about 22,404 (220)

Synthesis of 5-Substituted Pyrimidine Nucleosides

Chemical and Pharmaceutical Bulletin, 1965
Uridine-5-carboxaldehyde (I), uridien-5-carboxylic acid (II), and 1-(β-D-ribofuranosyluronic acid) uracil-5-carboxaldehyde (III) were isolated and characterized form the reaction products obtained after catalytic oxidation of uridine-5-methanol (IV). Five aldehyde hydrazone derivatives of I and III were synthesized.
K, Imai, M, Honjo
openaire   +3 more sources

Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy [PDF]

, 2017
Acyclic nucleoside phosphonates (ANPs) are nowadays one of the key drugs in the treatment of DNA virus and retrovirus infections. In this work, we report the synthesis and antiviral evaluation of phosphonoamidate and diamidates prodrugs of C5-pyrimidine ...
Albadry, Najmiyah, Andrei, Graciela, Pertusati, Fabrizio, Serafini, Sara, Snoeck, Robert   +4 more
core   +2 more sources

How Plants May Maintain Protein Homeostasis Under Rising Atmospheric CO2

Plant, Cell &Environment, Volume 49, Issue 5, Page 2654-2672, May 2026.
ABSTRACT Vascular plants may employ several physiological mechanisms to stabilize their protein contents as atmospheric CO2 concentrations change over a day, year, decade, or century. One mechanism is that plants may rely more on soil ammonium as their nitrogen source when CO2 increases.
Arnold J. Bloom, Xiaoxiao Shi, Nathan M. Hannon   +2 more
wiley   +1 more source

The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates

Bioinorganic Chemistry and Applications, 2010
Conjugates of purine and pyrimidine nucleosides: thymidine and 2-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties.
Agnieszka B. Olejniczak, Jan Milecki, Grzegorz Schroeder   +2 more
doaj   +1 more source

Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry [PDF]

, 2012
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several ...
Addepalli, Bramsen, Caruthers, Chandrasekhar, Chevolot, Chittepu, Corey, Crooke, de Miguel, Dierckx, Duschinsky, Dyrager, Eguchi, El-Sagheer, Gutierrez, Inoue, Jayaprakash, Jean-Paul Desaulniers, Kaczmarek, Kuboyama, Kumar, Lachmann, Liu, Montevecchi, Nielsen, Nitin, Ostergaard, Pan, Park, Qing, Robins, Singh, Takarada, Tim Efthymiou, van Delft, Varizhuk, Wagner, Wei Gong, Whiting, Yamada, Yu   +40 more
core   +1 more source

Drug design and identification of potent leads against Mycobacterium tuberculosis thymidine monophosphate kinase [PDF]

, 2012
Antiviral chemotherapy often relies on nucleoside analogues, which, once phophorylated by intracellular kinases, target viral polymerases impeding DNA synthesis. In contrast, nucleoside analogues are much less explored as antibacterial drugs.
Munier-Lehmann, H, Pocet, S, Van Calenbergh, Serge   +2 more
core   +3 more sources

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Effect of C5-Methylation of Cytosine on the UV-Induced Reactivity of Duplex DNA: Conformational and Electronic Factors [PDF]

, 2016
International audienceC5-methylation of cytosines is strongly correlated with UV-induced mutations detected in skin cancers. Mutational hot-spots appearing at TCG sites are due to the formation of pyrimidine cyclobutane dimers (CPDs).
Banyasz, Akos, Douki, Thierry, Esposito, Luciana, Improta, Roberto, Lepori, Clément, Markovitsi, Dimitra, Perron, Marion   +6 more
core   +3 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, Volume 36, Issue 33, 23 April 2026.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

RNA synthesis in mitochondria isolated from rat liver [PDF]

, 1977
Mitochondrial RNA (mtRNA) was synthesized from purine and pyrimidine nucleosides in coupling with oxidative phosphorylation using isolated mitochondria. The in vivo synthesized mtRNA was adenine-uracil rich and sedimented at about 20 S by sucrose density
Inaba, Kozo, Oda, Takuzo
core   +1 more source