Results 121 to 130 of about 68,807 (327)

Zur Kenntniss der Pyrimidine [PDF]

, 1897
Siegfried Ruhemann, A. S. Hemmy
openalex   +1 more source

PYRIMIDINE NUCLEOSIDES AS PRECURSORS OF PYRIMIDINES IN POLYNUCLEOTIDES [PDF]

Journal of Biological Chemistry, 1950
E. Hammarsten, E. Hammarsten, Peter Reichard, Peter Reichard, E. Saluste, E. Saluste   +5 more
openaire   +1 more source

Synthesis and Metal‐Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2‐Diamine Groups

ChemBioChem, EarlyView.
The findings of thermal denaturation experiments indicate that duplexes containing thymine analogues with 1,2‐ethylenediamine side chains show stabilizing effects with six metal ions (e.g., Cu(II), Ni(II), Zn(II), Co(II), Cd(II)). The 1,2‐diamine side chain demonstrated to be useful as a new metal‐ion binding site. Thymidine analogue with a 1,2‐diamino
Takahiro Atsugi, Shoji Fujiwara, Jiro Kondo, Akira Ono   +3 more
wiley   +1 more source

Synthesis and Antioxidant Activities of Novel Pyrimidine Acrylamides as Inhibitors of Lipoxygenase: Molecular Modeling and In Silico Physicochemical Studies

Molecules
The pyrimidine ring is present in various biomolecules such as DNA and RNA bases, aminoacids, vitamins, etc. Additionally, many clinically used drugs including methotrexate and risperidone contain the pyrimidine heterocyclic scaffold as well.
Michail Saragatsis, Eleni Pontiki
doaj   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Serendipitous Identification of Azine Anticancer Agents Using a Privileged Scaffold Morphing Strategy

Molecules
The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development.
Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Silvia Filippi, Eleonora Mancin, Lia Fiaschi, Elisa De Marchi, Federica Giammarino, Chiara Vagaggini, Bruno Mattia Bizzarri, Raffaele Saladino, Elena Dreassi, Maurizio Zazzi, Lorenzo Botta   +13 more
doaj   +1 more source

An Indole Dearomatization Strategy for the Synthesis of Pseudo‐Natural Products

ChemBioChem, Accepted Article.
The indole moiety is a privileged fragment that frequently populates existing bioactive compound collections. We describe the development of an indole‐dearomatization sequence and its application for library expansion of a collection of indole‐containing pseudo‐NPs.
Joseph G.F. Hoock, Annina Burhop, Luca C. Greiner, Beate Schölermann, Celine Da Cruz Lopes Guita, Jie Liu, Sukdev Bag, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Slava Ziegler, Michael Grigalunas, Herbert Waldmann   +13 more
wiley   +1 more source

The Origin of Purine and Pyrimidine Deoxyribose in Escherichia coli Systems

, 1959
Marilyn R. Loeb, Seymour S. Cohen
openalex   +1 more source

Inability of two Hydantoins to act as Precursors of Pyrimidines in Ribonucleic Acid. [PDF]

, 1950
S. Bergström, E. Hammarsten, Peter Reichard   +2 more
openalex   +1 more source

Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration

ChemistryEurope, EarlyView.
A photocatalyzed aminative carbonylation of unactivated alkenes mediated by nitrogen radicals has been developed. Various β‐aminoketones were produced effectively from allyl alcohols containing different aromatic heterocycles. Abstract Carbon monoxide, as a crucial C1 synthon, has been widely used in the difunctionalization of alkenes.
Ming Hou, Yuanrui Wang, Hefei Yang, Jiajun Zhang, Xiao‐Feng Wu   +4 more
wiley   +1 more source