Results 191 to 200 of about 35,554 (229)

Metabolomic Insights Into the Impact of a Maternal Western‐Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Plasma metabolites in adult offspring reflecting metabolic programming during critical developmental windows. ABSTRACT Perinatal nutrition influences offspring metabolic phenotype and obesity risk. This study examines how a maternal obesogenic diet and offspring's leptin supplementation during suckling affect the metabolome in offspring adulthood ...
Catalina A. Pomar, Rocío A. Martin‐Chamorro, Petr Zouhar, Pedro Castillo, Tomas Cajka, Jan Kopecky, Andreu Palou, Mariona Palou, Catalina Picó   +8 more
wiley   +1 more source

Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Kane A. C. Bastick, Caleb E. Griesbach, Ben Zhen Huang, Morgan J. Cordell, Yang (Daniel) Ou, Alán Aspuru‐Guzik, Andrei K. Yudin   +6 more
wiley   +2 more sources

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

RNA‐Lebendzellmikroskopie via click‐funktionalisierter TriPPPro Nucleotid‐Reporter

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Die intrazelluläre Zufuhr von trans‐Cycloocten und Bicyclo[6.1.0]nonin als sterisch anspruchsvolle Gruppen für die Diels–Alder‐Reaktion mit inversem Elektronenbedarf wurde durch die Triphosphat‐Prodrug‐Strategie (TriPPPro) erreicht. Nach der Hydrolyse innerhalb der Zelle werden die modifizierten Uridine und Cytidine metabolisch in die neu entstehende ...
J. Iven H. Knaack, Eileen List, Dörte Stalling, Vincente T. Sterrenberg, Chris Meier, Hans‐Achim Wagenknecht, Jens B. Bosse   +6 more
wiley   +1 more source

Pyrimidine [PDF]

, 2017
openaire   +2 more sources

Live‐Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters

Angewandte Chemie International Edition, Volume 65, Issue 2, 9 January 2026.
The intracellular delivery of trans‐cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron‐demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro) strategy. Once hydrolyzed inside cells, the modified uridines and cytidines are metabolically incorporated into nascent RNA, are labelled by a dual ...
J. Iven H. Knaack, Eileen List, Dörte Stalling, Vincente T. Sterrenberg, Chris Meier, Hans‐Achim Wagenknecht, Jens B. Bosse   +6 more
wiley   +1 more source

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

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Pyrimidines. XIII. Novel pyrimidine to pyrimidine transformation reactions

Journal of Heterocyclic Chemistry, 1977
AbstractNovel pyrimidine to pyrimidine transformation reactions are described. 1,3‐Dimethyl‐(or diethyl)‐uracil(1) are converted into isocytosine, 2‐thiouracil or uracil derivatives by treatment with guanidine, thiourea or urea, respectively. The latter two cases require base catalysis. The effects of some substituents at C‐5 and C‐6 of 1,3‐dialkylated
Kosaku Hirota, Kyoichi A. Watanabe, Jack J. Fox   +2 more
openaire   +1 more source

ChemInform Abstract: PYRIMIDINES. XIII. NOVEL PYRIMIDINE TO PYRIMIDINE TRANSFORMATION REACTIONS

Chemischer Informationsdienst, 1977
AbstractBei der Behandlung mit Guanidin (II) erhält man aus 1,3‐Dimethyluracil sowie den . analogen Verbindungen (I) die Pyrimidinone (III).
K. HIROTA, K. A. WATANABE, J. J. FOX
openaire   +1 more source