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The Chemistry and Bio-Medicinal Significance of Pyrimidines & Condensed Pyrimidines
Current Topics in Medicinal Chemistry, 2016This review discusses the biological and medicinal significance of one of the most important and interesting heterocyclic ring systems, the pyrimidine and its condensed derivatives. Herein, various physiologically important molecules, as well as, therapeutically used drugs having a pyrimidine or condensed pyrimidine system in their chemical structures,
M. S. Sanap +10 more
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The Effect of Different Purines and Pyrimidines on Human Pyrimidine Biosynthesis
1977Hereditary orotaciduria is caused by the patient’s inability to convert orotic acid to uridine monophosphate, due to an absence of the activity of orotidine phosphate decarboxylase in all cases and orotate phosphoribosyl-transferase in all cases but one. All or nearly all of the orotic acid formed by biosynthesis must be excreted or degraded. Therefore,
A. Rauch-Janssen +2 more
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1975
Publisher Summary This chapter covers the literature for the period from the latter part of 1994 to the early part of 1998. This period has seen the continued use of pyrimidine drugs—such as AZT and ddC in the treatment of viral diseases and the development of new analogues of these compounds, for example, 3TC (3’-thiocytosine).
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Publisher Summary This chapter covers the literature for the period from the latter part of 1994 to the early part of 1998. This period has seen the continued use of pyrimidine drugs—such as AZT and ddC in the treatment of viral diseases and the development of new analogues of these compounds, for example, 3TC (3’-thiocytosine).
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Pyrimidines. VIII. Pyrimidine Derivatives of Thioguanine
Journal of Medicinal and Pharmaceutical Chemistry, 1962Henry C. Koppel +3 more
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New England Journal of Medicine, 1973
PURINE metabolism in man has been studied extensively since the time of Garrod. Its end product is a readily measurable purine, uric acid, which reflects overall purine metabolism and, in uricotelic organisms, the major pathway of nitrogen excretion as well.
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PURINE metabolism in man has been studied extensively since the time of Garrod. Its end product is a readily measurable purine, uric acid, which reflects overall purine metabolism and, in uricotelic organisms, the major pathway of nitrogen excretion as well.
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Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion
Journal of the American Chemical Society, 2022Richmond Sarpong
exaly
1954
Publisher Summary This chapter provides an overview of purines and pyrimidines. The recognition of the biological importance of purines and pyrimidines as constituents of nucleic acids has been responsible for much research concerning the enzymatic processes involved in the biosynthesis and degradation of these compounds.
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Publisher Summary This chapter provides an overview of purines and pyrimidines. The recognition of the biological importance of purines and pyrimidines as constituents of nucleic acids has been responsible for much research concerning the enzymatic processes involved in the biosynthesis and degradation of these compounds.
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Iron Catalyzed Synthesis of Pyrimidines Under Air
Advanced Synthesis and Catalysis, 2020Gargi Chakraborty +2 more
exaly