Results 111 to 120 of about 2,340 (179)

Targeted treatment of hypophosphatemia with trametinib in HRAS-related mosaic RASopathy. [PDF]

Orphanet J Rare Dis
Mirza A, Rossi C, Kulozik A, Banan R, Sahm F, Harrabi S, Syrbe S, Choukair D.   +7 more
europepmc   +1 more source

Ex-situ generation of gaseous nitriles in two-chamber glassware for facile haloacetimidate synthesis. [PDF]

Beilstein J Org Chem
Akselvoll NB, Larsen JT, Pedersen CM.
europepmc   +1 more source

Encorafenib plus binimetinib versus dabrafenib plus trametinib for the first-line treatment of patients with BRAF^V600E-mutant metastatic non-small cell lung cancer: a matching-adjusted indirect treatment comparison. [PDF]

ESMO Open
Planchard D, Mazières J, Grouin JM, Le Reun C, Luttenauer H, Boussahoua M, Macabeo B.   +6 more
europepmc   +1 more source

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Synthesis of fluorinated pyrimidinones

Journal of Fluorine Chemistry, 2013
Abstract A method for the construction of fluorinated pyrimidinones based on the reaction of cyanodifluoromethyl-substituted amines with isocyanates is described. The use of ortho-iodophenylisocyanate in this reaction followed by copper catalyzed intramolecular amination affords fluorinated fused heterocycles – 4-fluoropyrimido[1,6-a]benzimidazol-1 ...
Alexander Dilman, Alexander Korlyukov, Kosobokov Mikhail   +2 more
exaly   +2 more sources

New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics

Archiv der Pharmazie, 2012
AbstractA series of novel substituted pyrimidinones and fused pyrimidinones (compounds 3–18) were synthesized starting with oxiranylmethanone 2. The in vitro cytotoxicity against a human breast adenocarcinoma (MCF‐7) cell line was investigated and most of the tested compounds showed potent cytotoxic activity against the MCF‐7 cell line comparable to ...
Aymn E, Rashad, Ahmed H, Shamroukh, Nabil M, Yousif, Mowafia A, Salama, Hatem S, Ali, Mamdouh M, Ali, Abeer E, Mahmoud, Mahmoud, El-Shahat   +7 more
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Pyrimidinones as biodynamic agents

1987
In view of the diverse types of biological activities associated with pyrimidinones and molecules having pyrimidinone as a component substructure, the pyrimidinone moiety may be considered as an important pharmacophore for incorporation in the design of molecules of biological interest.
A K, Saxena, S, Sinha
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Ethynyltriisopropoxytitanium reactions with pyrimidinones

Journal of Organometallic Chemistry, 1988
Abstract Ethynyltriisopropoxytitanium has been generated in situ from ethynyllithium and chlorotriisopropoxytitanium at −80°C. It forms 1 1 adducts with pyrimidin-2(1 H )-ones with exclusive carbon-carbon bond formation at C(6). The products after quenching ethynylmagnesium bromide with chlorotriisopropoxytitanium at −10°C are 1 1 the ...
Frode Rise, David Grace, Kjell Undheim
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ChemInform Abstract: New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics.

ChemInform, 2013
AbstractA series of new pyrimidinone derivatives is synthesized starting from oxiranyl aryl ketone (I).
Aymn E. Rashad, Ahmed H. Shamroukh, Nabil M. Yousif, Mowafia A. Salama, Hatem S. Ali, Mamdouh M. Ali, Abeer E. Mahmoud, Mahmoud El‐Shahat   +7 more
openaire   +1 more source

An Unusual Condensation of Pyrimidinones: Synthesis of Bipyrimidinones and Bipyrimidinylmethane

HETEROCYCLES, 1991
An unusual condensation of pyrimidinones in the presence of lithiated furan derivatives or LiHMDS leads to the formation of 7, 8 and 13. In the case of the self condensation of 3, a novel acyloin reaction is invoked to explain the formation of product where the substrate acts as the catalyst in the ...
M. BOTTA, SALADINO R, A. GAMBACORTA, R. NICOLETTI   +3 more
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Antineoplastic properties of pyrimidinone interferon inducers

Advances in Enzyme Regulation, 1981
Abstract The interferon inducing, antiviral and antitumor activities of a new series of pyrimidinone compounds are compared and summarized in this report. An interesting split in mechanism of action appeared to exist in these compounds. One group represented by ABPP were very potent interferon inducing agents and the antiviral and antitumor activity ...
openaire   +2 more sources