Results 101 to 110 of about 5,835 (244)

Pentafluorophenylammonium triflate (PFPAT) catalyzed facile construction of substituted chromeno[2,3-d]pyrimidinone derivatives and their antimicrobial activity

Journal of Advanced Research, 2014
A new, simple thermally efficient and solvent-free condensation of 2-amino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-ethylcarboxylate derivatives with coumarin-3-carboxylic acid employing pentafluorophenylammonium triflate (PFPAT) as an inexpensive ...
Majid Ghashang, Syed Sheik Mansoor, Krishnamoorthy Aswin   +2 more
doaj   +1 more source

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria

Scientific Reports
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, M. Chiara Fusco, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris   +9 more
doaj   +1 more source

Dérivés de 2(1H)-pyrimidinones et d'isatogènes : synthèse, application de la chimie clic et activités biologiques [PDF]

, 2011
La synthèse de 1,2,3-triazoles disubstitués originaux via la cycloaddition 1,3-dipolaire catalysée par le cuivre(I) entre un alcyne et un azoture (CuAAC), en utilisant les dérivés éthynyles de la 2(1H)-pyrimidinone, les dérivés azides de la 2(1H ...
Najahi, Ennaji
core  

Density functional theory calculations, vibration spectral analysis and molecular docking of the antimicrobial agent 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl] sulfanyl}pyrimidin-4(3H)-one

Open Chemistry, 2018
Almutairi Maha S., Soumya S., Al-Wabli Reem I., Joe I. Hubert, Attia Mohamed I.   +4 more
doaj   +1 more source

From Meldrum's acid to biogically relevant chiral heterocycles : syntheses of pyrazolidinones, pyrimidinones and isoxazolidinones using domino organocatalyzed reactions [PDF]

, 2015
Dans le cadre de cette thèse, nous nous sommes tournés vers l'utilisation de l'acide de Meldrum en tant que plateforme pour la synthèse d'hétérocycles chiraux par organocatalyse.
Pair, Etienne
core  

Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines. [PDF]

RSC Adv, 2023
Naikoo RA, Kumar R, Sharma R, Mahajan D, Bhargava G.   +4 more
europepmc   +1 more source

Butadienyl Ketene: An Unexplored Intermediate in Organic Synthesis

SynOpen
Maninderjeet K. Mann, Simranpreet K. Wahan, Nitin Tandon, Gaurav Bhargava   +3 more
doaj   +1 more source

Efficient sodium selenate-catalyzed synthesis of 3,4-dihydro-2(1H)-pyrimidinones and –thiones under solvent-free conditions

Bulletin of the Chemical Society of Ethiopia, 2009
Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or –thiones in excellent yields.
Rahim Hekmatshoar, Maryam Heidari, Majid M. Heravi, Bita Baghernejad   +3 more
doaj  

Novel Pyrimidinones as SHP2 Antagonists for Treating Cancer [PDF]

ACS Medicinal Chemistry Letters, 2020
openaire   +2 more sources

Summary of Research: Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease: Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Trials (the ENHANCE Trials). [PDF]

Adv Ther
Anzueto A, Barjaktarevic IZ, Siler TM, Rheault T, Rickard K, O'Donovan K, Sciurba F.   +6 more
europepmc   +1 more source