Results 81 to 90 of about 5,835 (244)
Introduction of Poly(4-Vinylpyridine) as an Efficient Promotor for the Synthesis of Pyrano[2,3-d]Pyrimidinones and Pyrido[2,3-d]Pyrimidines [PDF]
, 2018 This article describes an efficient method for the synthesis of pyrano[2,3-d]pyrimidinones and pyrido[2,3-d]pyrimidines via promotion of the condensation of aromatic aldehydes, malononitrile and barbituric acid and/or 6-amino-1,3-dimethyluracil in the ...
Farhad Shirini (703231) +3 more
core +1 more source
Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers +16 more
wiley +1 more source
Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors [PDF]
, 2018 In this study, a series of conformationally restricted thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones was designed and synthesized with the goal of improving the biological activity as 17-hydroxysteroid dehydrogenase type 2 ...
Hartmann, Rolf W. +2 more
core +1 more source
Pyrimidinone: versatile Trojan horse in DNA photodamage?
Photochemical & Photobiological Sciences, 2015 Abstract (6-4) Photolesions between adjacent pyrimidine DNA bases are prone to secondary photochemistry. It has been shown that singlet excited (6-4) moieties form Dewar valence isomers as well as triplet excitations. We here report on the triplet state of a minimal model for the (6-4) photolesion, 1-methyl-2(1H)-pyrimidinone.
Mathias, Micheel +3 more
openaire +3 more sources
ChemSusChem, Volume 19, Issue 8, 28 April 2026.Heterogeneous catalysis has historically been developed in the gas phase, however, we have found it pertinent to highlight solvent effects that must be accounted for in liquid environments. Condensed phase catalysis, like that in biomass, petroleum and the conversion of CO2, stands to benefit from the typically overlooked discussion regarding the ...
Jim B. Floyd +3 more
wiley +1 more source
Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors [PDF]
, 2016 HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral replication, but integrase inhibitors as marketed drugs have just very recently started to emerge.
Annalise Di Marco (2338006) +17 more
core +1 more source
Hydrogels for Bone Repair: Construction Strategies and Applications
Smart Medicine, Volume 5, Issue 2, April 2026.This review establishes an integrated framework for bone repair hydrogels, covering construction strategies from material selection to functional modification, mechanical and biological characterization, and diverse applications including defect repair, fracture healing, and smart responsive systems.
Miaomiao Wang +7 more
wiley +1 more source
Molecules, 2012 In this study, the antinociceptive properties of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives 5a–i at doses of 25 and 50 mg/kg were evaluated in mice, using the abdominal constriction test.
Francisco J. B. Mendonça Junior +8 more
doaj +1 more source
Small Structures, Volume 7, Issue 4, April 2026.This review highlights ionic liquid‐based self‐healing polymer electrolytes as a promising route toward safer, resilient solid‐state batteries. By combining nonvolatile plasticization, dynamic supramolecular interactions, and tailored polymer architectures, these materials can simultaneously improve ionic conductivity, mechanical robustness, and ...
Zhijun Wu +6 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney +3 more
wiley +1 more source