Results 81 to 90 of about 2,914 (164)

Synthesis and biological evaluation of 2-methoxy- and 2-Methylthio-6-[(2′-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity

, 1999
The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished.
CONTI CINZIA, OCCHIONERO FRANCESCA, MASTROMARINO PAOLA, BOTTA, MAURIZIO, MAGRINI MAURIZIO, NICOLETTI ROSARIO, SALADINO RAFFAELE   +6 more
core   +1 more source

Solvent-free and green synthesis of fused pyrimidine derivatives catalyzed by pillar[5]arene-based Lewis acid ionic liquid

Scientific Reports
This study presents a solvent-free and green approach for the synthesis of novel 7,9-diaryl-6H,7H-chromeno[4,3-d]thiazolo[3,2-a]pyrimidin-6-one (DCTP) derivatives using a newly developed pillar[5] arene-based Lewis acid ionic liquid (P5/Py[CuBr2]Br) as ...
Soheila Rastegar, Iraj Mohammadpoor-Baltork, Saeid Asghari, Shahram Tangestaninejad, Majid Moghadam, Behrouz Notash   +5 more
doaj   +1 more source

Pentafluorophenylammonium triflate (PFPAT) catalyzed facile construction of substituted chromeno[2,3-d]pyrimidinone derivatives and their antimicrobial activity

Journal of Advanced Research, 2014
A new, simple thermally efficient and solvent-free condensation of 2-amino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-ethylcarboxylate derivatives with coumarin-3-carboxylic acid employing pentafluorophenylammonium triflate (PFPAT) as an inexpensive ...
Majid Ghashang, Syed Sheik Mansoor, Krishnamoorthy Aswin   +2 more
doaj   +1 more source

Introduction of Poly(4-Vinylpyridine) as an Efficient Promotor for the Synthesis of Pyrano[2,3-d]Pyrimidinones and Pyrido[2,3-d]Pyrimidines

, 2018
This article describes an efficient method for the synthesis of pyrano[2,3-d]pyrimidinones and pyrido[2,3-d]pyrimidines via promotion of the condensation of aromatic aldehydes, malononitrile and barbituric acid and/or 6-amino-1,3-dimethyluracil in the ...
Farhad Shirini (703231), Omid Goli-Jolodar (5905964), Leyla Nazemi Nasirmahale (5905961), Hassan Tajik (5905967)   +3 more
core   +1 more source

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria

Scientific Reports
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, M. Chiara Fusco, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris   +9 more
doaj   +1 more source

Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

, 2016
HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral replication, but integrase inhibitors as marketed drugs have just very recently started to emerge.
Annalise Di Marco (2338006), Federica Orvieto (2417227), Edith Monteagudo (2094247), Marco Ferrara (2094259), Massimiliano Fonsi (2335426), Peter J. Felock (2335495), Monica Donghi (2350966), Michael Rowley (2094223), Cristina Gardelli (2350957), Fabrizio Fiore (2238334), Ester Muraglia (2338012), Ralph Laufer (2238340), Odalys Gonzalez-Paz (2452147), Emanuela Nizi (2094238), Giovanna Pescatore (2369413), Vincenzo Summa (2094232), Olaf Kinzel (129105), Benedetta Crescenzi (1705666)   +17 more
core   +1 more source

Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-d] Pyrimidinones

Pharmaceuticals
Background: Recently, pyrido[2,3-d] pyrimidine, triazolopyrimidine, thiazolopyrimidine, quinoline, and pyrazole derivatives have gained attention due to their diverse biological activities, including antimicrobial, antioxidant, antitubercular, antitumor,
Ameen Ali Abu-Hashem, Sami A. Al-Hussain
doaj   +1 more source

‐quinazolin‐4‐ones via Diels–Alder Adducts of Phenyl Vinyl Sulfone to Cyclobutene‐Annelated Pyrimidinones

, 2006
Under basic conditions (Et3N, dioxane), the aromatic amidines 4 and also S-methylisothiourea 4g cleanly undergo Michael addition to methyl 2-chloro-2-cyclopropylideneacelate (5), followed by intramolecular nucleophilic substitution, cyclopropyl to ...
Nizamov, Shamil, Armin de Meijere, Rauch, Karsten, Finsinger, Dirk, Suryakanta Dalai, Belov, Vladimir N., de Meijere, Armin, Shamil Nizamov, Dalai, Suryakanta, Dirk Finsinger, Karsten Rauch, Vladimir N. Belov   +11 more
core   +1 more source

Dérivés de 2(1H)-pyrimidinones et d'isatogènes : synthèse, application de la chimie clic et activités biologiques [PDF]

, 2011
La synthèse de 1,2,3-triazoles disubstitués originaux via la cycloaddition 1,3-dipolaire catalysée par le cuivre(I) entre un alcyne et un azoture (CuAAC), en utilisant les dérivés éthynyles de la 2(1H)-pyrimidinone, les dérivés azides de la 2(1H ...
Najahi, Ennaji
core  

Asymmetric Carbon−Carbon Bond Formations in Conjugate Additions of Lithiated N-Boc Allylic and Benzylic Amines to Nitroalkenes:  Enantioselective Synthesis of Substituted Piperidines, Pyrrolidines, and Pyrimidinones

, 2016
(−)-Sparteine mediated lithiations of N-Boc-allylic and benzylic amines provide configurationally stable intermediates which on conjugate additions to nitroalkenes provide highly enantioenriched enecarbamate products in good yields, and with high ...
Timothy A. Johnson (2384710), Brian W. Slafer (2096023), Doo Ok Jang (2191435), Peter Beak (2402176), Michael D. Curtis (2538214)   +4 more
core   +1 more source