Results 71 to 80 of about 3,637 (213)

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents

Acta Pharmaceutica, 2017
A novel series of carbamothioylamino-benzene-sulfonamide-thiophene-carboxylates 4a-c and thieno[3,2-d]pyrimidin-2-yl-amino-benzene-sulfonamides 5a-c were synthesized in a series of synthetic steps and were used as key intermediates for the synthesis of ...
Hafez Hend N., Alsalamah Sulaiman A., El-Gazzar Abdel-Rhman B. A.   +2 more
doaj   +1 more source

Sigmatropic rearrangements in 5-allyloxytetrazoles [PDF]

, 2011
Mechanisms of thermal isomerization of allyl tetrazolyl ethers derived from the carbocyclic allylic alcohols cyclohex-2-enol and 3-methylcyclohex-2-enol and from the natural terpene alcohol nerol were investigated.
Abell, Abramovitch, Amin Ismael, Araújo, Araújo, Barkley, Basch, Becke, Bugalho, Bugalho, Cristiano, Cristiano, Cristiano, Cristiano, Daniela V. Coelho, Desarro, Dąbkowska, Frija, Frija, Frija, Frija, Frija, Frija, Frisch, Gu, Gómez-Zavaglia, Hashimoto, Head-Gordon, Igor Reva, Johnstone, Koldobskii, Lee, Luís M. T. Frija, M. Lurdes S. Cristiano, Mavromoustakos, McCarthy, Mishra, Pacios, Peng, Peng, Rui Fausto, Sandmann, Tamura, Toney   +43 more
core   +1 more source

Diels-alder cycloaddition of 2-azadienes to methyl 2-(2,6-dichlorophenyl)-2H-azirine-3-carboxylate in the synthesis of methyl 4-oxo-1,3-diazabicyclo[4.1.0]heptane-6-carboxylates [PDF]

, 2004
A number of fused 4-oxo-1,3-diazabicyclo[4.1.0]heptane-6-carboxylates, a new type of compound, have been obtained by Diels-Alder cycloaddition between nucleophilic 2-azadienes and an electrophilic 2H-azirine.
Alves, M. José, Durães, M. Miguel, Fortes, A. Gil   +2 more
core   +1 more source

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BMC Cancer, 2017
Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer ...
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa   +9 more
doaj   +1 more source

A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

, 2012
International audienceVariously substituted novel dihydropyridoazepinones have been prepared by an intermolecular radical addition followed by a radical cyclisation on a pyridine ring. The latter process involved the use of a combination of two different
Botez, I., Petit, Laurent, Tizot, A., Zard, Samir,   +3 more
core   +3 more sources

Green Synthesis of Pyrazol‑chromeno[2,3‑d]pyrimidinones Using SBA-Pr-SO3H as an Efficient Nanocatalyst [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2017
Hexagonal mesoporous silica (SBA-15) was prepared and then functionalized by(3-mercaptopropyl)trimethoxysilane. The obtained 3-mercaptopropyl functionalized SBA-15 (SBA-Pr-SH) was then oxidized using H2O2 in methanol under an acidic condition to give ...
Ghodsi Mohammadi Ziarani, Fatemeh Saidian, Parisa Gholamzadeh, Alireza Badiei, Ali Abolhasani Soorki   +4 more
doaj  

Sex-associated differences in baseline urinary metabolites of healthy adults. [PDF]

, 2018
The biological basis for gender variability among disease states is not well established. There have been many prior efforts attempting to identify the unique urine metabolomic profiles associated with specific diseases.
Anger, Jennifer T, Eilber, Karyn S, Fan, Sili, Fiehn, Oliver, Kim, Jayoung, Shahid, Muhammad, Yeon, Austin   +6 more
core   +1 more source

One-Pot Eco-Safe Saccharin-Catalyzed Procedure for Expedient and Convenient Synthesis of Dihydropyrano[2,3-c]pyrazole, Tetrahydrobenzo[b]pyran and Pyrano[2,3-d]pyrimidinone Scaffolds as a Green and Versatile Catalyst

Indonesian Journal of Chemistry, 2018
A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation ...
Farzaneh Mohamadpour, Mojtaba Lashkari, Nourallah Hazeri   +2 more
doaj   +1 more source

Substituentenkonstanten des Pyrazol-, 1,2,3-Triazol-, Benzotriazol- und Naphthotriazol-Restes [PDF]

, 1986
Die Synthese von Benzoesäuren mit den im Titel genannten Resten in m- bzw. p-Position (15, 13, 11, 9) sowie ihrer Ethyl- und Methylester wird beschrieben.
Anliker, Cepciansky, Dabard, Fischer, Flitsch, Flitsch, Fritzsche, Gold, Griffiths, Jaffe, Langhals, Veibel, Zweidler   +12 more
core   +1 more source

NITROIMIDAZOLES XI1 [I]: SYNTHESES OF TRISUBSTITUTED PYRAZOLES AND SUBSTITUTED (1 -METHYL-5-NITRO-2- IMIDAZOLYL) PYRIMIDINONES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1995
The reaction of P-diketones 1 with phenyl hydrazine afforded 5-aryl-3-(1- methyl-5-nitro-2-imidazoly1)-1-phenylpyrazole (2) and 3-aryl-5-(1-methyl-5- nitro-2-imidazoly1) -1-phenylpyrazole (3).
doaj