Results 61 to 70 of about 3,637 (213)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Mesoporous molecular sieve MCM-41 catalyzed one-pot synthesis of 3,4-dihydro-2(1H)-pyrimidinones and –thiones under solvent-free conditions

Bulletin of the Chemical Society of Ethiopia, 2011
An efficient synthesis of 3,4-dihydro-2(1H)-pyrimidinones and -thiones using MCM-41 as the catalyst from an aldehyde, β-keto ester, and urea or thiourea under solvent-free conditions is described.
Rahim Hekmatshoar, Maryam Heidari, Majid. M. Heravi, Bita Baghernejad   +3 more
doaj  

Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents

Molecules, 2012
In this study, the antinociceptive properties of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives 5a–i at doses of 25 and 50 mg/kg were evaluated in mice, using the abdominal constriction test.
Francisco J. B. Mendonça Junior, Sebastião J. de Melo, Elisa Soares Leite, Almir G. Wanderley, Luciana Scotti, Marcus T. Scotti, João H. Costa-Silva, Janaína V. dos Anjos, Rajendra M. Srivastava   +8 more
doaj   +1 more source

ChemInform Abstract: Microwave‐Assisted, Mild, Facile, and Rapid One‐Pot Three‐Component Synthesis of Some Novel Pyrano[2,3‐d]pyrimidine‐2,4,7‐triones. [PDF]

, 2012
Novel pyrano[2,3-d]pyrimidine-2,4,7-triones were synthesized in 90–97% yield via a three-component reaction of an aromatic aldehyde, Meldrums acid, and barbituric acid in the presence of 10 mol % K2CO3 under microwave irradiation.
Pasha, M.A., Sadeq Hamood Saleh Azzam, .
core   +2 more sources

Functional Materials for Environmental Energy Harvesting in Smart Agriculture via Triboelectric Nanogenerators

Advanced Functional Materials, Volume 36, Issue 13, 12 February 2026.
This review explores functional and responsive materials for triboelectric nanogenerators (TENGs) in sustainable smart agriculture. It examines how particulate contamination and dirt affect charge transfer and efficiency. Environmental challenges and strategies to enhance durability and responsiveness are outlined, including active functional layers ...
Rafael R. A. Silva, Giulio Fatti, Emanuel Carlos, Guilherme Ferreira, Sumita Goswami, Suman Nandy, Luiz H. C. Mattoso, Elvira Fortunato, Caio G. Otoni, Rodrigo Martins   +9 more
wiley   +1 more source

Aza-Michael mono-addition using acidic alumina under solventless conditions [PDF]

, 2016
Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the ...
Abdilla, Roderick, Bosica, Giovanna
core   +2 more sources

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, Volume 36, Issue 17, 26 February 2026.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion [PDF]

, 2016
The role of molecular chaperones, among them heat shock proteins (Hsps), in the development of malaria parasites has been well documented. Hsp70s are molecular chaperones that facilitate protein folding.
Addmore Shonhai, Earl Prinsloo, Heini W. Dirr, Heinrich Hoppe, Ikechukwu Achilonu, Tawanda Zininga   +5 more
core   +2 more sources

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

Polarize the Solvent to Regulate the Intermediate Phase and Dynamic Crystallization of Perovskite Films

Advanced Materials, Volume 38, Issue 12, 25 February 2026.
A solvent engineering strategy using polar polymers is introduced to regulate perovskite crystallization dynamics in solar cells. Strongly polarized fluorinated groups stabilize the intermediate phase and control solvent exfoliation, leading to high‐quality films with suppressed defects.
Zhuoqiong Zhang, Yunfan Wang, Weizhen Wang, Yulan Huang, Shanchao Ouyang, Yonggui Sun, Fei Wang, Xianfang Zhou, Guichuan Xing, Shu Kong So, Guozhong Xing, Hanlin Hu, Songhua Cai, Sai‐Wing Tsang, Tom Wu   +14 more
wiley   +1 more source