Results 61 to 70 of about 5,835 (244)

Solid-Phase Synthesis of Oligo-2-Pyrimidinone-2'-Deoxyribonucleotides and Oligo-2-Pyrimidinone-2'-Deoxyriboside Methylphosphonates [PDF]

Nucleic Acids Research, 1996
A synthetic method was developed for the synthesis of oligodeoxyribonucleotides and oligodeoxyribonucleoside methylphosphonates comprised exclusively of the fluorescent 2-pyrimidinone base for the first time. The method utilized the solid-phase 2-cyanoethylphosphoramidite and methylphosphonamidite chemistry for internucleotide couplings and a ...
Y, Zhou, P O, Ts'o
openaire   +2 more sources

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles

Heterocyclic Communications, 2019
New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with ...
Zaki Remon M., Kamal El-Dean Adel M., Radwan Shaban M., Saber Ahmed F.   +3 more
doaj   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA)

Molecules, 2023
Staphylococcus aureus is a common human pathogen. Methicillin-resistant Staphylococcus aureus (MRSA) infections pose significant and challenging therapeutic difficulties.
Shraddha S. Ambade, Vivek Kumar Gupta, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale   +4 more
doaj   +1 more source

Long‐Term Hydrophilic, Anti‐Clotting, and Anti‐Fibrotic Dynamic Covalent Silicone‐Based Biomaterials

Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.
Dynamic covalent crosslinking of a Schiff‐base silicone elastomer with hydrazide‐functionalized polymers is demonstrated to improve the long‐term hydrophilicity as well as the anti‐fouling and anti‐clotting properties of PDMS implants. The hydrazone‐functionalized material prevents hydrophobic recovery, resists clotting, and significantly reduces ...
Norma A. Garza Flores, Eva Mueller, Robert Bui, James C. Fredenburgh, Ruiqi Yin, Rawaa Hussain, Rida A. Malik, Thomas Kalab, Dabeer Abdul‐Azeez, Fei Xu, Michael Brook, Jeffrey I. Weitz, Todd Hoare   +12 more
wiley   +1 more source

Dynamic Supramolecular Polyurethane Elastomers Enabling Bioinspired Strain‐Adaptive Stiffening to Resolve the Softness–Strength Paradox

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Segmental‐level molecular engineering of a supramolecular polyurethane elastomer integrates strain‐adaptive chains, soft elastic segments, and dynamic hydrogen bonding motifs. This design reconciles skin‐like softness with muscle‐level strength, offering a sustainable and high‐performance material platform for next‐generation artificial skin and soft ...
Haoming Zou, Zhi‐Xiong Fei, Zhao Yang, Ke‐Ke Yang, Dong‐Xu Yang, Ling‐Ying Shi   +5 more
wiley   +1 more source

Dihydroquinazolinones by Titanocene‐Catalyzed Reductive Radical Addition to Quinazolinones

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
Tri‐ and tetracyclic dihydroquinazolinones or quinazolinones by titanocene catalysis: A highly diastereoselective and efficient reductive radical addition to quinazolinones enables an unprecedented entry to pharmaceutically relevant dihydroquinazolinones by avoiding the interception of radical intermediates prior to the slow radical addition.
Thomas Heinrichs, Fabian Lang, Konstantin Woitol, Jana Vohn, Andreas Schneider, Andreas Gansäuer   +5 more
wiley   +1 more source

Thiazolidinedione–Pyrazolopyrimidinone Molecular Hybrids With Alkyl Spacers: Potential Antitubercular Agents Complemented by Molecular Modeling

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
We report the synthesis of 21 novel thiazolidinedione–pyrazolopyrimidinone derivatives (12a–u), prepared by coupling thiazolidinedione and pyrazolopyrimidinone pharmacophores through various alkyl linkers. The compounds were characterized spectroscopically and evaluated against the Mtb H37Rv strain, identifying compounds 5c and 5d as potent ...
Pule Seboletswe, Gobind Kumar, Nontobeko Gcabashe, Sanjeev Dhawan, Neha Manhas, Ankit, Audrey Jordaan, Digby F. Warner, Parvesh Singh   +8 more
wiley   +1 more source

An unexpected and efficient direct nucleophilic C-4 hydroxy substitution on 2-methoxy- and 2-mrthylthio-4(3H)-pyrimidinones bearing a diethylamino moiety on the C-6 side chain [PDF]

, 1997
The unexpected and efficient direct nucleophilic C-4 hydroxy (oxo) substitution by sodium alkoxides on 2-methoxy- and 2-methylthio-4(3H)- pyrimidinones bearing a diethylamino moiety on the c-6 side chain is reported.
BOTTA M, Saladino R., Occhionero F., OCCHIONERO F, SALADINO R, CRESTINI C, Crestini C., Nicoletti R., NICOLETTI R, Botta M.   +9 more
core   +3 more sources