Results 61 to 70 of about 2,340 (179)

Solvent-free and green synthesis of fused pyrimidine derivatives catalyzed by pillar[5]arene-based Lewis acid ionic liquid

Scientific Reports
This study presents a solvent-free and green approach for the synthesis of novel 7,9-diaryl-6H,7H-chromeno[4,3-d]thiazolo[3,2-a]pyrimidin-6-one (DCTP) derivatives using a newly developed pillar[5] arene-based Lewis acid ionic liquid (P5/Py[CuBr2]Br) as ...
Soheila Rastegar, Iraj Mohammadpoor-Baltork, Saeid Asghari, Shahram Tangestaninejad, Majid Moghadam, Behrouz Notash   +5 more
doaj   +1 more source

Pentafluorophenylammonium triflate (PFPAT) catalyzed facile construction of substituted chromeno[2,3-d]pyrimidinone derivatives and their antimicrobial activity

Journal of Advanced Research, 2014
A new, simple thermally efficient and solvent-free condensation of 2-amino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-ethylcarboxylate derivatives with coumarin-3-carboxylic acid employing pentafluorophenylammonium triflate (PFPAT) as an inexpensive ...
Majid Ghashang, Syed Sheik Mansoor, Krishnamoorthy Aswin   +2 more
doaj   +1 more source

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria

Scientific Reports
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, M. Chiara Fusco, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris   +9 more
doaj   +1 more source

Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-d] Pyrimidinones

Pharmaceuticals
Background: Recently, pyrido[2,3-d] pyrimidine, triazolopyrimidine, thiazolopyrimidine, quinoline, and pyrazole derivatives have gained attention due to their diverse biological activities, including antimicrobial, antioxidant, antitubercular, antitumor,
Ameen Ali Abu-Hashem, Sami A. Al-Hussain
doaj   +1 more source

Synthesis of new binary trimethoxyphenylfuran pyrimidinones as proficient and sustainable corrosion inhibitors for carbon steel in acidic medium: experimental, surface morphology analysis, and theoretical studies

BMC Chemistry
In this study, synthesis and assessment of the corrosion inhibition of four new binary heterocyclic pyrimidinones on CS in 1.0 M hydrochloric acid solutions at various temperatures (30–50 °C) were investigated. The synthesized molecules were designed and
Hajar A. Ali, Ahmed. A. El-Hossiany, Ashraf S. Abousalem, Mohamed A. Ismail, Abd El-Aziz S. Fouda, Eslam A. Ghaith   +5 more
doaj   +1 more source

Density functional theory calculations, vibration spectral analysis and molecular docking of the antimicrobial agent 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl] sulfanyl}pyrimidin-4(3H)-one

Open Chemistry, 2018
Almutairi Maha S., Soumya S., Al-Wabli Reem I., Joe I. Hubert, Attia Mohamed I.   +4 more
doaj   +1 more source

The chemistry of imidazoles and pyrimidinones [PDF]

, 1997
The reactions of amino- and formylimidazoles, and aminopyrimidinones are described. Conditions were found for the successful condensation of 5(4)-aminoimidazole-4(5)-carboxamide with a number of substituted benzaldehydes, to provide a series of novel 5(4)-N-benzylideneaminoimidazole-4(5)-carboxamides. Reaction of a subset of the benzylidene derivatives
openaire   +1 more source

Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines. [PDF]

RSC Adv, 2023
Naikoo RA, Kumar R, Sharma R, Mahajan D, Bhargava G.   +4 more
europepmc   +1 more source

Butadienyl Ketene: An Unexplored Intermediate in Organic Synthesis

SynOpen
Maninderjeet K. Mann, Simranpreet K. Wahan, Nitin Tandon, Gaurav Bhargava   +3 more
doaj   +1 more source

Efficient sodium selenate-catalyzed synthesis of 3,4-dihydro-2(1H)-pyrimidinones and –thiones under solvent-free conditions

Bulletin of the Chemical Society of Ethiopia, 2009
Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or –thiones in excellent yields.
Rahim Hekmatshoar, Maryam Heidari, Majid M. Heravi, Bita Baghernejad   +3 more
doaj