Results 61 to 70 of about 2,914 (164)

Role of 1D and 2D Materials in Achieving Transparent and Flexible Lithium‐Ion Batteries for Wearable Electronics

Small, EarlyView.
Hybrid 1D–2D architectures redefine material design strategies for TFLIBs by decoupling competing performance parameters. This approach accelerates the transition of TFLIBs from proof of concept to practical wearable technologies. ABSTRACT Transparent and flexible lithium‐ion batteries (TFLIBs), enabled by advanced nanomaterials and flexible ...
Raviraj Madesan, Anand Sreekantan Thampy
wiley   +1 more source

Mechanistic Investigations into the Photochemistry of 4-Allyl-tetrazolones in Solution:  A New Approach to the Synthesis of 3,4-Dihydro-pyrimidinones

, 2016
Photolysis (λ = 254 nm) of 4-allyl-tetrazolones 2a−c was carried out in methanol, 1-propanol, 1-hexanol, acetonitrile, and cyclohexane. The sole primary photochemical process identified was molecular nitrogen elimination, with formation of pyrimidinones ...
M. Lurdes S. Cristiano (2248654), Igor V. Khmelinskii (2642482), Luís M. T. Frija (2495575)   +2 more
core   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Research on anti-HIV-1 agents. Part 2. Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase

, 2001
A small library of 2,6-disubstituted- and 2,5,6-trisubstituted-4(3H)-pyrimidinones has been synthesized by solid-phase synthesis starting from a modified Merrifield resin. The new pyrimidinones have been tested in vitro for their ability to inhibit HIV-1
Botta, Maurizio, Renzulli, M., Manetti, Fabrizio, Spadari, S., Maga, G., Corelli, Federico   +5 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Self-assembled pentamers and hexamers linked through quadruple-hydrogen-bonded 2-ureido-4 [1H]-pyrimidinones

, 2005
The preorganization of bifunctional 2-ureido-4-pyrimidinones mediated by either 1,3-substituted adamantane or meta-substituted phenylene ring linkers leads to the preferred formation of stable pentameric (1)5 and hexameric (2)6 assemblies, respectively ...
Mendoza, J de, Segura, M, Prados, P, Meijer, E.W., Henk M. Keizer, Sijbesma, RP Rint, Keizer, H.M., Sijbesma, R.P., Meijer, EW Bert, Gonzalez, J.J., Segura, M., Margarita Segura, E. W. Meijer, Keizer, HM Henk, Rint P. Sijbesma, Gonzalez, JJ, Pilar Prados, Prados, P., Juan J. González, Javier de Mendoza, Mendoza, de, J.   +20 more
core   +1 more source

Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors [PDF]

, 2018
In this study, a series of conformationally restricted thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones was designed and synthesized with the goal of improving the biological activity as 17-hydroxysteroid dehydrogenase type 2 ...
Hartmann, Rolf W., Marchais-Oberwinkler, Sandrine, Perspicace, Enrico   +2 more
core   +1 more source

Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones

, 2018
Dozens of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones were synthesized in a straightforward method by condensation of substituted 2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-diones or N-methyl-2H-thieno[2,3-d][1, 3 ...
Jian-Guo Cao (6159491), Guo-Zheng Huang (6159500), Si-Si Wang (2035588), Fei-Ze Liu (6159494), Haji Akber Aisa (7312430), Li-Fei Nie (6159488), Hainimu Xiamuxi (6159497)   +6 more
core   +1 more source

Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents

Molecules, 2012
In this study, the antinociceptive properties of 3,4-dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile derivatives 5a–i at doses of 25 and 50 mg/kg were evaluated in mice, using the abdominal constriction test.
Francisco J. B. Mendonça Junior, Sebastião J. de Melo, Elisa Soares Leite, Almir G. Wanderley, Luciana Scotti, Marcus T. Scotti, João H. Costa-Silva, Janaína V. dos Anjos, Rajendra M. Srivastava   +8 more
doaj   +1 more source