Results 41 to 50 of about 3,637 (213)

Dynamic Supramolecular Polyurethane Elastomers Enabling Bioinspired Strain‐Adaptive Stiffening to Resolve the Softness–Strength Paradox

Advanced Science, EarlyView.
Segmental‐level molecular engineering of a supramolecular polyurethane elastomer integrates strain‐adaptive chains, soft elastic segments, and dynamic hydrogen bonding motifs. This design reconciles skin‐like softness with muscle‐level strength, offering a sustainable and high‐performance material platform for next‐generation artificial skin and soft ...
Haoming Zou, Zhi‐Xiong Fei, Zhao Yang, Ke‐Ke Yang, Dong‐Xu Yang, Ling‐Ying Shi   +5 more
wiley   +1 more source

Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles

Heterocyclic Communications, 2019
New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with ...
Zaki Remon M., Kamal El-Dean Adel M., Radwan Shaban M., Saber Ahmed F.   +3 more
doaj   +1 more source

Dihydroquinazolinones by Titanocene‐Catalyzed Reductive Radical Addition to Quinazolinones

Chemistry – A European Journal, EarlyView.
Tri‐ and tetracyclic dihydroquinazolinones or quinazolinones by titanocene catalysis: A highly diastereoselective and efficient reductive radical addition to quinazolinones enables an unprecedented entry to pharmaceutically relevant dihydroquinazolinones by avoiding the interception of radical intermediates prior to the slow radical addition.
Thomas Heinrichs, Fabian Lang, Konstantin Woitol, Jana Vohn, Andreas Schneider, Andreas Gansäuer   +5 more
wiley   +1 more source

CoMFA and CoMSIA Studies on Inhibitors of HIV-1 Integrase - Bicyclic Pyrimidinones

E-Journal of Chemistry, 2010
To understand the structural requirements of HIV-1 integrase inhibitors and to design new ligands against human HIV-1 integrase with enhanced inhibitory potency, a 3D QSAR (quantitative structure-activity relationship) study with comparative molecular ...
V. Radhika, S. Sree Kanth, M. Vijjulatha
doaj   +1 more source

An efficient synthesis of new fluorinated uracil derivatives [PDF]

, 2003
A series of potentially biologically active fluorinated uracil derivatives has been prepared in three steps from oxazolines and fluorinated nitriles with good chemical yields.Fustero Lardies, Santos, Santos.Fustero@uv.es ; Sanz Cervera, Juan Francisco ...
Asensio Martínez, Amparo, Fustero Lardiés, Santos, Piera, Julio, Salavert, Esther, Sanz Cervera, Juan Francisco   +4 more
core   +1 more source

Conjugated Polymers Engineered for Flexible/Stretchable Electronics

Journal of Polymer Science, EarlyView.
This review highlights glass transition temperature (Tg) as the central parameter linking molecular structure to device performance in conjugated polymers. By tuning backbone rigidity, side‐chain architecture, and dynamic bonding, Tg governs the balance between π–π stacking–enabled charge transport and mechanical compliance.
Yunchong Yang, Josh Bass, Weijia Yan, Ashwath Anand, Chunka Zhou, Jingjing Qiu   +5 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Optimization of Anti-kinking Designs for Vascular Grafts Based on Supramolecular Materials

Frontiers in Materials, 2020
Synthetic vascular grafts to be applied as access grafts for hemodialysis often require anti-kinking properties. Previously, electrospun microporous vascular implants based on synthetic supramolecular materials have been shown to perform adequately as ...
Dan Jing Wu, Dan Jing Wu, Dan Jing Wu, Kim van Dongen, Kim van Dongen, Kim van Dongen, Wojciech Szymczyk, Wojciech Szymczyk, Paul J. Besseling, Ruth M. Cardinaels, Giulia Marchioli, Giulia Marchioli, Giulia Marchioli, Marcel H. P. van Genderen, Marcel H. P. van Genderen, Carlijn V. C. Bouten, Carlijn V. C. Bouten, Anthal I. P. M. Smits, Anthal I. P. M. Smits, Patricia Y. W. Dankers, Patricia Y. W. Dankers, Patricia Y. W. Dankers   +21 more
doaj   +1 more source

Evaluation of Neurotropic Activity and Molecular Docking Study of New Derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines on the Basis of pyrano[3,4-c]pyridines

Molecules, 2022
Background: Heterocyclic compounds and their fused analogs, which contain pharmacophore fragments such as pyridine, thiophene and pyrimidine rings, are of great interest due to their broad spectrum of biological activity.
Shushanik Sh. Dashyan, Eugene V. Babaev, Ervand G. Paronikyan, Armen G. Ayvazyan, Ruzanna G. Paronikyan, Lernik S. Hunanyan   +5 more
doaj   +1 more source

Bio‐Inspired Molecular Events in Poly(Ionic Liquids)

Advanced Functional Materials, Volume 36, Issue 38, 11 May 2026.
Originating from dipolar and polar inter‐ and intra‐chain interactions of the building blocks, the topologies and morphologies of poly(ionic liquids) (PIL) govern their nano‐ and micro‐processibility. Modulating the interactions of cation‐anion pairs with aliphatic dipolar components enables the tunability of properties, facilitated by “bottom‐up ...
Jiahui Liu, Marek W. Urban
wiley   +1 more source