Results 31 to 40 of about 2,340 (179)

Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles

Heterocyclic Communications, 2019
New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with ...
Zaki Remon M., Kamal El-Dean Adel M., Radwan Shaban M., Saber Ahmed F.   +3 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA)

Molecules, 2023
Staphylococcus aureus is a common human pathogen. Methicillin-resistant Staphylococcus aureus (MRSA) infections pose significant and challenging therapeutic difficulties.
Shraddha S. Ambade, Vivek Kumar Gupta, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale   +4 more
doaj   +1 more source

Conjugated Polymers Engineered for Flexible/Stretchable Electronics

Journal of Polymer Science, EarlyView.
This review highlights glass transition temperature (Tg) as the central parameter linking molecular structure to device performance in conjugated polymers. By tuning backbone rigidity, side‐chain architecture, and dynamic bonding, Tg governs the balance between π–π stacking–enabled charge transport and mechanical compliance.
Yunchong Yang, Josh Bass, Weijia Yan, Ashwath Anand, Chunka Zhou, Jingjing Qiu   +5 more
wiley   +1 more source

Binder Design in Extrusion‐Based 3D Printing of Electrodes: Enhancing Printability and Electrochemical Performance in Energy Storage Devices

Small, EarlyView.
Binder design plays a pivotal role in extrusion‐based 3D printing of energy storage electrodes by simultaneously governing ink printability and electrochemical performance. This review examines how diverse binder materials and design strategies are employed to enable printability while addressing key electrochemical challenges in energy storage devices,
Akesh Manimendra Badalge, Timothy J. Biddle, Huynh Tam Minh Nguyen, Eric Campbell, Munkhbayar Batmunkh, Tak Kim, Stefanie Feih, Yu Lin Zhong   +7 more
wiley   +1 more source

CoMFA and CoMSIA Studies on Inhibitors of HIV-1 Integrase - Bicyclic Pyrimidinones

E-Journal of Chemistry, 2010
To understand the structural requirements of HIV-1 integrase inhibitors and to design new ligands against human HIV-1 integrase with enhanced inhibitory potency, a 3D QSAR (quantitative structure-activity relationship) study with comparative molecular ...
V. Radhika, S. Sree Kanth, M. Vijjulatha
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Optimization of Anti-kinking Designs for Vascular Grafts Based on Supramolecular Materials

Frontiers in Materials, 2020
Synthetic vascular grafts to be applied as access grafts for hemodialysis often require anti-kinking properties. Previously, electrospun microporous vascular implants based on synthetic supramolecular materials have been shown to perform adequately as ...
Dan Jing Wu, Dan Jing Wu, Dan Jing Wu, Kim van Dongen, Kim van Dongen, Kim van Dongen, Wojciech Szymczyk, Wojciech Szymczyk, Paul J. Besseling, Ruth M. Cardinaels, Giulia Marchioli, Giulia Marchioli, Giulia Marchioli, Marcel H. P. van Genderen, Marcel H. P. van Genderen, Carlijn V. C. Bouten, Carlijn V. C. Bouten, Anthal I. P. M. Smits, Anthal I. P. M. Smits, Patricia Y. W. Dankers, Patricia Y. W. Dankers, Patricia Y. W. Dankers   +21 more
doaj   +1 more source

Evaluation of Neurotropic Activity and Molecular Docking Study of New Derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines on the Basis of pyrano[3,4-c]pyridines

Molecules, 2022
Background: Heterocyclic compounds and their fused analogs, which contain pharmacophore fragments such as pyridine, thiophene and pyrimidine rings, are of great interest due to their broad spectrum of biological activity.
Shushanik Sh. Dashyan, Eugene V. Babaev, Ervand G. Paronikyan, Armen G. Ayvazyan, Ruzanna G. Paronikyan, Lernik S. Hunanyan   +5 more
doaj   +1 more source