Results 31 to 40 of about 3,637 (213)

Synthesis and Studies of Alkynyl Pyrimidinones as Metaphase Inhibitors. [PDF]

Acta Chemica Scandinavica, 1991
Methods are described for the syntheses of chloromethyl propargyl ethers and propargyl halides substituted with a hydroxyalkyl group, and their use in alkylation reactions of 2-pyrimidinones. The N-alkynyl derivatives are reversible inhibitors of mitosis in the metaphase of the cell-cycle. The in vivo screening was on Chang liver cells.
Tore Benneche, Gunnar Keilen, Jan Solberg, Reidar Oftebro, Kjell Undheim, Lars I. Elding   +5 more
openaire   +2 more sources

Quinazolin-4-ones, Thienopyrimidin-4-ones and Related Compounds: New Highly Active Powdery Mildewicides [1]

CHIMIA, 2003
In this short review, new quinazolinones and thieno-pyrimidinones with outstanding powdery mildew activity are introduced. The most important inventions of two major players in this field, DuPont and Syngenta, are presented and interesting ...
Harald Walter, Ronald Zeun
doaj   +1 more source

Synthesis of Isoxazolo[4,5‐D]Pyrimidinones, and their Isomerization into Oxazolo[4,5‐D]Pyrimidinones on Flash Vacuum Pyrolysis

Bulletin des Sociétés Chimiques Belges, 1994
AbstractA series of new 3‐phenylisoxazolo[4,5‐d]pyrimidinones 5a‐d were prepared from 5‐aminoisoxazole‐4‐carboxylic acid esters. Upon flash‐vacuum pyrolysis, these heterocycles are isomerized into hitherto unreported 2‐phényloxazolo[4,5‐d] ‐pyrimidinones 8a‐d.
Laurent, Sophie, Flammang, Robert, Barbieux-Flammang, Monique, Van Haverbeke, Yves, Wentrup, Curt   +4 more
openaire   +4 more sources

Prediction and evaluation of pyrimidinones derivatives: DFT analysis, corrosion inhibition, and bioactivity studies

Results in Surfaces and Interfaces
Analyzing binary heterocyclic pyrimidinones using density functional theory (DFT) calculations and Monte Carlo (MC) simulations, as well as assessing their ADME (Absorption, Distribution, Metabolism, and Excretion) and toxicological properties is the ...
Ahmed M. Wahba, Kamel Shoueir, Abd El-Aziz S. Fouda   +2 more
doaj   +1 more source

A Synthetic Approach to Pyrazolopyranopyrimidinones and Pyrazolopyranooxazinones as Antimicrobial Agents

Journal of Chemistry, 2016
The hitherto unknown 6-amino-4-(2-chloro-5-nitrophenyl)-3-methyl-1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile 1a was synthesized. Both 1a and its 2,4 dichlorophenyl derivative 1b were utilized as building blocks for the preparation of novel class of ...
A. K. Elziaty, G. Bassioni, A. M. A. Hassan, H. A. Derbala, M. S. Abdel-Aziz   +4 more
doaj   +1 more source

The role of phosphotungstic acid in enhancing the catalytic performance of UiO-66 (Zr) and its applications as an efficient solid acid catalyst for coumarins and dihydropyrimidinones synthesis

Catalysis Communications, 2022
In recent study, we report a facile and easy technique for the synthesis phosphotungstic acid (PTA) with different weight contents (10, 25, 50 and 75 wt%) loaded on UiO-66 (Zr) as efficient and reusable catalysts for the preparation of coumarin and ...
Fares T. Alshorifi, Dina E. Tobbala, Salah M. El-Bahy, Mohamed A. Nassan, Reda S. Salama   +4 more
doaj   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA)

Molecules, 2023
Staphylococcus aureus is a common human pathogen. Methicillin-resistant Staphylococcus aureus (MRSA) infections pose significant and challenging therapeutic difficulties.
Shraddha S. Ambade, Vivek Kumar Gupta, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale   +4 more
doaj   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Solid-Phase Synthesis of Oligo-2-Pyrimidinone-2'-Deoxyribonucleotides and Oligo-2-Pyrimidinone-2'-Deoxyriboside Methylphosphonates [PDF]

Nucleic Acids Research, 1996
A synthetic method was developed for the synthesis of oligodeoxyribonucleotides and oligodeoxyribonucleoside methylphosphonates comprised exclusively of the fluorescent 2-pyrimidinone base for the first time. The method utilized the solid-phase 2-cyanoethylphosphoramidite and methylphosphonamidite chemistry for internucleotide couplings and a ...
Y, Zhou, P O, Ts'o
openaire   +2 more sources