Results 31 to 40 of about 5,835 (244)

Solid Phase Synthesis of 2,6-Disubstituted-4(3H)-pyrimidinones Targeting HIV-1 Reverse Transcriptase [PDF]

, 1998
The solution and solid phase synthesis of 6-substituted 2-[(4- hydroxybutyl)amino]-4(3H)-pyrimidinones 1 as HIV-1 RT inhibitors is ...
F. MESSINA, Fabrizio Manetti, E. NIZI, Giovanni Maga, G. MAGA, Emanuela Nizi, Federico Corelli, MANETTI, FABRIZIO, CORELLI, FEDERICO, BOTTA, MAURIZIO, Flavia Messina, Maurizio Botta   +11 more
core   +1 more source

Electron impact ionization mass spectra of some substituted dipyrido[1,2-a:4,3-d]pyrimidinones [PDF]

, 1993
The electron impact ionization mass spectra of dipyrido [1,2-a:4,3-d] pyrimidinones are strongly influenced by the degree of aromaticity of the fused rings. The molecular ions of the compounds are fairly stable.
Huber Imre, Maki Esa, Fülöp Ferenc, Bernáth Gábor, Pihlaja Kalevi, Vainiotalo Pirjo   +5 more
core   +3 more sources

1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis and In Silico Molecular Docking Study

Molecules, 2022
Alteration of insect growth regulators by the action of inhibitors is becoming an attractive strategy to combat disease-transmitting insects. In the present study, we investigated the larvicidal effect of 1,2,3-triazolyl-pyrimidinone derivatives against ...
Katharigatta N. Venugopala, Pottathil Shinu, Christophe Tratrat, Pran Kishore Deb, Raquel M. Gleiser, Sandeep Chandrashekharappa, Deepak Chopra, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Fawzi M. Mahomoodally, Michelyne Haroun, Mahmoud Kandeel, Syed Mohammed Basheeruddin Asdaq, Viresh Mohanlall, Nizar A. Al-Shar’i, Mohamed A. Morsy   +16 more
doaj   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV. [PDF]

Arch Pharm (Weinheim)
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Leite DI, Macedo FB, Lima MMC, Brum IS, Oliveira JFM, Costa ACS, Duarte SC, Moon S, Moura SCB, Oliveira AP, Boechat N, Bastos MM.   +11 more
europepmc   +2 more sources

A facile synthesis of polysubstituted furo[2,3-d]pyrimidinones and 1,2,4-triazole-fused derivatives

Journal Chemical Research, 2020
In this paper, a series of polysubstituted furo[2,3-d]pyrimidinones, including 1,2,4-triazole-fused derivatives, are synthesized via aza-Wittig reactions of iminophosphoranes, under mild conditions.
Hai-Tao Gao, Jun-Kai Ma, Yanggen Hu, Hong-Mei Wang   +3 more
semanticscholar   +1 more source

Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs.
Kamilla Rodrigues Rogerio, Leonardo J M Carvalho, Luiza Helena Pinto Domingues, Bruno Junior Neves, José Teófilo Moreira Filho, Rosane Nora Castro, Cesare Bianco Júnior, Claudio Tadeu Daniel-Ribeiro, Carolina Horta Andrade, Cedric Stephan Graebin   +9 more
doaj   +1 more source

Five-Membered Heterocyclic Ring Via Dichalcones [PDF]

مجلة التربية والعلم, 2013
In this study some of dichalcone compounds (4-12) were prepared by the reaction of benzalacetone and its derivatives with a number of different ketones (acetophenone, acetanilide, 2-butanone).
N. Ahmad, O Ali
doaj   +1 more source

Promising antimicrobial agents: Synthetic approaches to novel tricyclic and tetracyclic pyrimidinones with antimicrobial properties [PDF]

, 2010
New tricyclic pyrimidinone derivatives were obtained from the corresponding thiazolopyrimidinone or hydrazino systems. The annelation of tricyclic hydrazino compound with 1,2,4-triazole and tetrazole moieties gave novel tetracyclic condensed ...
Usama M. Abdul-Raouf, Mark C. Bagley, Sherif, Sherif M., Abdul-Raouf, Usama M., Gaber, Hatem M., Bagley, Mark Christopher, Sherif M. Sherif, Hatem M. Gaber   +7 more
core   +1 more source

A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations

Zanco Journal of Pure and Applied Sciences, 2023
The Biginelli Reaction is a one-pot acid catalyzed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalized 3,4-dihydro-2(H)-pyrimidinones (DHPMs).
Rostam R. Braiem
doaj   +1 more source

Synthesis of Pyrazolo[1,5-α]pyrimidinone Regioisomers [PDF]

The Journal of Organic Chemistry, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lori K, Gavrin, Arthur, Lee, Brian A, Provencher, Walter W, Massefski, Stephen D, Huhn, Gregory M, Ciszewski, Derek C, Cole, John C, McKew   +7 more
openaire   +2 more sources