Results 31 to 40 of about 2,914 (164)
Angewandte Chemie, EarlyView.BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu +19 more
wiley +2 more sources
Synthesis and Self-Association of 4-Pyrimidinones
, 2016 Crystallization of 4-pyrimidinone from CHCl3 produced colorless needles that were shown by X-ray crystallography to consist of cyclic hydrogen-bonded dimers 2 of the 4(3H)-pyrimidinone tautomer 1.
Louis Vaillancourt (3045906) +2 more
core +1 more source
Microwave-assisted C-5 Iodination of substituted Pyrimidinones and Pirimidine nucleosides
, 2003 Direct microwave-assisted iodination of several pyrimidinones and pyrimidine nucleosides with N-iodosuccinimide to give the corresponding 5-iodo derivatives is described.
Lisa Paolini +8 more
core +1 more source
, 2018 The synthesis of previously unreported pyrazolo-pyrimidinones and isoxazolo-pyrimidinones are achieved via metal-free coupling of oxazine-2,6-diones with pyrazolidinone and isoxazolidinone, respectively. The synthesis provides easy access to a variety of
Girish Rawal +6 more
core +1 more source
Journal of Chemistry, 2016 The hitherto unknown 6-amino-4-(2-chloro-5-nitrophenyl)-3-methyl-1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile 1a was synthesized. Both 1a and its 2,4 dichlorophenyl derivative 1b were utilized as building blocks for the preparation of novel class of ...
A. K. Elziaty +4 more
doaj +1 more source
Synthesis and biological activity of some new fused thieno[2,3-b] pyridine derivatives; pyridothienopyrimidinones and pyridothienotriazinones [PDF]
Assiut University Journal of Multidisciplinary Scientific Research, 2016 3-Amino-4-aryl-5-ethoxycarbonyl-6-methylthieno[2,3-b]pyrindine-2-carboxamides 3a,b wereprepared and reacted with triethyl orthoformate to give pyridothienopyrimidinone derivatives4a,b.
doaj +1 more source
Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine
Advanced Healthcare Materials, EarlyView.Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi +2 more
wiley +1 more source
Solid Phase Synthesis of 2,6-Disubstituted-4(3H)-pyrimidinones Targeting HIV-1 Reverse Transcriptase
, 1998 The solution and solid phase synthesis of 6-substituted 2-[(4- hydroxybutyl)amino]-4(3H)-pyrimidinones 1 as HIV-1 RT inhibitors is ...
F. MESSINA +11 more
core +1 more source
Advanced Materials, EarlyView.This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley +1 more source
Advanced Science, EarlyView.Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta +6 more
wiley +1 more source