Results 91 to 100 of about 5,835 (244)

‐quinazolin‐4‐ones via Diels–Alder Adducts of Phenyl Vinyl Sulfone to Cyclobutene‐Annelated Pyrimidinones [PDF]

, 2006
Under basic conditions (Et3N, dioxane), the aromatic amidines 4 and also S-methylisothiourea 4g cleanly undergo Michael addition to methyl 2-chloro-2-cyclopropylideneacelate (5), followed by intramolecular nucleophilic substitution, cyclopropyl to ...
Nizamov, Shamil, Armin de Meijere, Rauch, Karsten, Finsinger, Dirk, Suryakanta Dalai, Belov, Vladimir N., de Meijere, Armin, Shamil Nizamov, Dalai, Suryakanta, Dirk Finsinger, Karsten Rauch, Vladimir N. Belov   +11 more
core   +1 more source

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents

Acta Pharmaceutica, 2017
A novel series of carbamothioylamino-benzene-sulfonamide-thiophene-carboxylates 4a-c and thieno[3,2-d]pyrimidin-2-yl-amino-benzene-sulfonamides 5a-c were synthesized in a series of synthetic steps and were used as key intermediates for the synthesis of ...
Hafez Hend N., Alsalamah Sulaiman A., El-Gazzar Abdel-Rhman B. A.   +2 more
doaj   +1 more source

Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction

Chemical Communications, 2014
An NHC-catalyzed regio- and stereoselective Mannich/lactamization domino reaction of N-(benzothiazolyl)imines with α-chloroaldehydes has been developed.
Qijian Ni, Xiaoxiao Song, Jiawen Xiong, G. Raabe, D. Enders   +4 more
semanticscholar   +1 more source

The chemistry of imidazoles and pyrimidinones [PDF]

, 1997
The reactions of amino- and formylimidazoles, and aminopyrimidinones are described. Conditions were found for the successful condensation of 5(4)-aminoimidazole-4(5)-carboxamide with a number of substituted benzaldehydes, to provide a series of novel 5(4)-N-benzylideneaminoimidazole-4(5)-carboxamides. Reaction of a subset of the benzylidene derivatives
openaire   +1 more source

NITROIMIDAZOLES XI1 [I]: SYNTHESES OF TRISUBSTITUTED PYRAZOLES AND SUBSTITUTED (1 -METHYL-5-NITRO-2- IMIDAZOLYL) PYRIMIDINONES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1995
The reaction of P-diketones 1 with phenyl hydrazine afforded 5-aryl-3-(1- methyl-5-nitro-2-imidazoly1)-1-phenylpyrazole (2) and 3-aryl-5-(1-methyl-5- nitro-2-imidazoly1) -1-phenylpyrazole (3).
doaj  

Green Synthesis of Pyrazol‑chromeno[2,3‑d]pyrimidinones Using SBA-Pr-SO3H as an Efficient Nanocatalyst [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2017
Hexagonal mesoporous silica (SBA-15) was prepared and then functionalized by(3-mercaptopropyl)trimethoxysilane. The obtained 3-mercaptopropyl functionalized SBA-15 (SBA-Pr-SH) was then oxidized using H2O2 in methanol under an acidic condition to give ...
Ghodsi Mohammadi Ziarani, Fatemeh Saidian, Parisa Gholamzadeh, Alireza Badiei, Ali Abolhasani Soorki   +4 more
doaj  

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BMC Cancer, 2017
Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer ...
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa   +9 more
doaj   +1 more source

Asymmetric Carbon−Carbon Bond Formations in Conjugate Additions of Lithiated N-Boc Allylic and Benzylic Amines to Nitroalkenes:  Enantioselective Synthesis of Substituted Piperidines, Pyrrolidines, and Pyrimidinones [PDF]

, 2016
(−)-Sparteine mediated lithiations of N-Boc-allylic and benzylic amines provide configurationally stable intermediates which on conjugate additions to nitroalkenes provide highly enantioenriched enecarbamate products in good yields, and with high ...
Timothy A. Johnson (2384710), Brian W. Slafer (2096023), Doo Ok Jang (2191435), Peter Beak (2402176), Michael D. Curtis (2538214)   +4 more
core   +1 more source

One-Pot Eco-Safe Saccharin-Catalyzed Procedure for Expedient and Convenient Synthesis of Dihydropyrano[2,3-c]pyrazole, Tetrahydrobenzo[b]pyran and Pyrano[2,3-d]pyrimidinone Scaffolds as a Green and Versatile Catalyst

Indonesian Journal of Chemistry, 2018
A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation ...
Farzaneh Mohamadpour, Mojtaba Lashkari, Nourallah Hazeri   +2 more
doaj   +1 more source

Solvent-free and green synthesis of fused pyrimidine derivatives catalyzed by pillar[5]arene-based Lewis acid ionic liquid

Scientific Reports
This study presents a solvent-free and green approach for the synthesis of novel 7,9-diaryl-6H,7H-chromeno[4,3-d]thiazolo[3,2-a]pyrimidin-6-one (DCTP) derivatives using a newly developed pillar[5] arene-based Lewis acid ionic liquid (P5/Py[CuBr2]Br) as ...
Soheila Rastegar, Iraj Mohammadpoor-Baltork, Saeid Asghari, Shahram Tangestaninejad, Majid Moghadam, Behrouz Notash   +5 more
doaj   +1 more source