Results 101 to 110 of about 83,545 (299)

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. [PDF]

PLoS Pathogens, 2014
Microbial agents can aggravate inflammatory diseases, such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). An example is pertussis toxin (PTX), a bacterial virulence factor commonly used as an adjuvant to
Aline Dumas, Nathalie Amiable, Juan Pablo de Rivero Vaccari, Jae Jin Chae, Robert W Keane, Steve Lacroix, Luc Vallières   +6 more
doaj   +1 more source

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish [PDF]

, 2008
Background A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa.
Kerry J Laing, Maureen K Purcell, James R Winton, John D Hansen   +3 more
core   +2 more sources

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Inflammatory caspases : key regulators of inflammation and cell death [PDF]

, 2014
The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel, Lamkanfi, Mohamed   +1 more
core   +2 more sources

Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity.

The Journal of biological chemistry, 2010
The innate immune system provides an initial line of defense against infection. Nucleotide-binding domain- and leucine-rich repeat-containing protein (NLR or (NOD-like)) receptors play a critical role in the innate immune response by surveying the cytoplasm for traces of intracellular invaders and endogenous stress signals.
Anderson S, Pinheiro, Martina, Proell, Clarissa, Eibl, Rebecca, Page, Robert, Schwarzenbacher, Wolfgang, Peti   +5 more
openaire   +1 more source

The pyrin inflammasome and the Yersinia effector interaction

Immunological Reviews, 2020
AbstractPyrin is a cytosolic pattern‐recognition receptor that normally functions as a guard to trigger capase‐1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA. The MEFV gene encoding human pyrin is preferentially expressed in phagocytes. Key domains in pyrin include a pyrin domain (PYD), a linker region, and a
Haleema S. Malik, James B. Bliska
openaire   +3 more sources

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.

PLoS Pathogens, 2020
Members of the family of pyrin and HIN domain containing (PYHIN) proteins play an emerging role in innate immunity. While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interferon ...
Matteo Bosso, Caterina Prelli Bozzo, Dominik Hotter, Meta Volcic, Christina M Stürzel, Annika Rammelt, Yi Ni, Stephan Urban, Miriam Becker, Mario Schelhaas, Sabine Wittmann, Maria H Christensen, Florian I Schmidt, Thomas Gramberg, Konstantin M J Sparrer, Daniel Sauter, Frank Kirchhoff   +16 more
doaj   +1 more source

Domain architecture evolution of pattern-recognition receptors [PDF]

, 2010
In animals, the innate immune system is the first line of defense against invading microorganisms, and the pattern-recognition receptors (PRRs) are the key components of this system, detecting microbial invasion and initiating innate immune defenses. Two
Qing Zhang, Christian M. Zmasek, Adam Godzik, SF Altschul, G Apic, NA Baker, MK Basu, A Bateman, B Beutler, TA Binkowski, AK Bjorklund, D Boraschi, CB Burge, AA Canutescu, RR Copley, JA Darling, R Desper, M Dlugosz, CB Do, SR Eddy, J Felsenstein, K Forslund, JH Fritz, O Gascuel, J Gough, JH Han, T Hibino, AL Hughes, AL Hughes, A Ishii, Z Kambris, TD Kanneganti, K Katoh, KJ Laing, O Lespinet, F Leulier, A Marchler-Bauer, A Marchler-Bauer, F Martinon, AF McGettrick, R Medzhitov, PA Nuin, LA O'Neill, H Oshiumi, L Patthy, K Pawlowski, NH Putnam, NH Putnam, H Qin, AJ Robertson, F Ronquist, L Sael, N Saitou, JM Sasin, HA Schmidt, E Sodergren, A Stamatakis, C Stein, JP Ting, J Weiner 3rd, AP West, MJ West-Eberhard, Q Zhang   +62 more
core   +2 more sources

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source