Results 121 to 130 of about 35,163 (154)

Effects of Botulinum Toxin A on Rosacea-Like Inflammation in an LL-37-Induced Rosacea Mouse Model. [PDF]

Ann Dermatol
Yoon D, Lee JO, Jang YN, Yoo KH, Kim BJ, Choi SY.   +5 more
europepmc   +1 more source

<i>Veronicastrum sibiricum</i> (L.) Pennell extract alleviates inflammation‑induced muscle atrophy through NLRP3 inflammasome regulation and mitochondrial function restoration. [PDF]

Mol Med Rep
Lee E, Kwon M, Nam JO.
europepmc   +1 more source

Structural Characterization of Squid Peptides and Evaluation of Their Antiphotoaging Activity in Nude Mice. [PDF]

Prev Nutr Food Sci
Peng Y, Tian M, Liu X, Su F.
europepmc   +1 more source

The Death-domain Fold of the ASC PYRIN Domain, Presenting a Basis for PYRIN/PYRIN Recognition [PDF]

Journal of Molecular Biology, 2003
The PYRIN domain is a conserved sequence motif identified in more than 20 human proteins with putative functions in apoptotic and inflammatory signalling pathways. The three-dimensional structure of the PYRIN domain from human ASC was determined by NMR spectroscopy. The structure determination reveals close structural similarity to death domains, death
Gottfried Otting, Eike Staub, Edgar Dahl   +2 more
exaly   +4 more sources

The effect of colchicine on pyrin and pyrin interacting proteins

Journal of Cellular Biochemistry, 2012
AbstractMEFV which encodes pyrin, cause familial Mediterranean fever (FMF), the most common auto‐inflammatory disease. Pyrin is believed to be a regulator of inflammation, though the nature of this regulatory activity remains to be identified.
Ekim Taşkıran, Engin Yilmaz
exaly   +4 more sources

CDC42 regulates PYRIN inflammasome assembly [PDF]

Cell Reports, 2022
The PYRIN inflammasome pathway is part of the innate immune response against invading pathogens. Unprovoked continuous activation of the PYRIN inflammasome drives autoinflammation and underlies several autoinflammatory diseases, including familial Mediterranean fever (FMF) syndrome.
Lotte Spel, Fabio Martinon
exaly   +3 more sources

Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes

Journal of Clinical Immunology, 2023
Pyrin is a cytosolic protein encoded by the MEFV gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the activation and secretion of IL-1β and IL-18. In addition, the Pyrin inflammasome activates Gasdermin D leading to pyroptosis, a highly pro-inflammatory cell death ...
Andy Wullaert, Jeroen Van Der Hilst, Wullaert Andy   +2 more
exaly   +5 more sources

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Inducing Pyroptosis Via the Pyrin Inflammasome

2023
The pyrin inflammasome detects bacterial toxins and effectors that inhibit RhoA GTPases and triggers inflammatory cytokine release and a fast cell death termed pyroptosis. In addition, various endogenous molecules, drugs, synthetic molecules, or mutations can trigger pyrin inflammasome activation.
Bronnec, Pauline, Sousa, Jeremy, Henry, Thomas   +2 more
openaire   +3 more sources