Results 131 to 140 of about 35,163 (154)

Corneal Toxicity of the Pediculocide A-200 Pyrinate

Archives of Ophthalmology, 1962
Five patients who had acute chemical erosion of the cornea secondary to the pediculocide A-200 Pyrinate * have been seen at the Massachusetts Eye and Ear Infirmary in the past 8 months. The symptoms were acute and severe, but complete healing ensued. All patients were between ages 3 and 8 years, and all had recently applied A-200 Pyrinate to the head ...
R D, REINECKE, R S, KINDER
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CATERPILLERs, pyrin and hereditary immunological disorders

Nature Reviews Immunology, 2006
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This family has gained rapid prominence because of its demonstrated and anticipated roles in immunity, cell death and growth, and diseases.
Jenny P-Y, Ting, Daniel L, Kastner, Hal M, Hoffman   +2 more
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Functional Assessment of Disease-Associated Pyrin Variants

2022
The pyrin inflammasome detects effectors and toxins that inhibit RhoA GTPases and triggers inflammatory cytokines release and a fast cell death termed pyroptosis. Ancient plague pandemics in the Mediterranean basin have selected in the human population pyrin variants that can trigger an autoinflammatory disease termed familial Mediterranean fever (FMF).
Chirita, Daria, Jamilloux, Yvan, Henry, Thomas, Magnotti, Flora   +3 more
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An alternative path for pyrin

Science Signaling, 2016
Mutations associated with an autoimmune disorder enable cells to assemble pyrin inflammasomes independently of microtubules.
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Pyrin variants can burn out the plague

Nature Reviews Immunology, 2020
Mutations in pyrin that cause the autoinflammatory disease familial Mediterranean fever may have been selected for during plague pandemics.
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Mutations in pyrin masquerading as a primary immunodeficiency

Clinical Immunology, 2016
Whole exome sequencing is increasingly used in the diagnosis of primary immunodeficiencies due to the overlapping and atypical presentations of these disorders. We report two patients who presented with recurrent infections and early onset colitis. They were investigated by whole exome sequencing due to suspicion of primary immunodeficiency and found ...
Yousef R. Badran, Mariam Rajab, Rima Hanna-Wakim, Wayne Bainter, Brittney Cangemi, Michel J. Massaad, Ghassan Dbaibo, Raif S. Geha, Janet Chou   +8 more
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Hereditary immunologic disorders caused by pyrin and cryopyrin

Current Allergy and Asthma Reports, 2007
A new family of hereditary immunologic disorders known as the autoinflammatory diseases involves dysregulation of the innate immune system. Elucidation of the genetic basis of these disorders has resulted in improved understanding of the disease pathophysiology of systemic and tissue inflammation, and has also revealed novel nonpathologic innate immune
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Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Cell Reports, 2022
Sophie Georgin-Lavialle, Michel Popoff, Thomas Henry   +2 more
exaly  

[The child with fever in pyrins time].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007
Kone-Paut, I., Hentgen, V., Guillaume, Serge, Touitou, I.   +3 more
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The pyrin inflammasome and the Yersinia effector interaction

Immunological Reviews, 2020
James B Bliska, Haleema Sadia Malik
exaly