Results 161 to 170 of about 88,038 (326)

First case of pyrin-associated autoinflammation with neutrophilic dermatosis complicated by amyloidosis [PDF]

, 2020
Masatomo Kiyota, Masafumi Oya, Masahiro Ayano, Hiroaki Niiro, Takeshi Iwasaki, Minako Fujiwara, Yoshinao Oda, Kyoko Fujimoto, Hiroaki Ida   +8 more
openalex   +1 more source

Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]

, 2015
Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Expanding clinical spectrum of autosomal dominant pyrin-associated autoinflammatory disorder caused by the heterozygous MEFV p.Thr577Asn variant [PDF]

, 2018
Haruna Nakaseko, Naomi Iwata, Kazushi Izawa, Hirofumi Shibata, Ryuhei Yasuoka, Toaki Kohagura, Naoki Abe, Shinji Kawabe, Ryuta Nishikomori   +8 more
openalex   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Mutations in the B30.2 and the Central Helical scaffold domains of pyrin differentially affect inflammasome activation [PDF]

, 2022
Daria Chirita, Flora Magnotti, Pauiine Bronnec, Sarah Dalmon, Amandine Martin, Michel R. Popoff, Mathieu Gerfaud‐Valentin, P. Sève, Alexandre Bélot, A. Contis, A. Duquesne, Gaëtane Nocturne, Irene lemelle, Sophie Georgin‐Lavialle, Guilaine Boursier, Isabelle Touitou, Yvan Jamilloux, Thomas Henry   +17 more
openalex   +1 more source

Uskottavaa dokumenttielokuvaa rakentamassa : Tarkastelun kohteena dokumentaarinen Shoot me! -elokuva [PDF]

, 2010
Opinnäytetyöni kirjallisessa osassa pyrin selvittämään vaikuttamisen keinoja, joita tekijä käyttää hyödyksi dokumenttielokuvan teon eri vaiheissa. Tämä on samalla kirjallisen työni näkökulma.
Ollila, Matti
core  

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

NLR family pyrin domain containing 6 (NLRP6; NALP6) [PDF]

, 2011

openalex   +1 more source

Kasvu-­ ja kehityskohteet B2C-­myyjästä B2B-­myyjäksi [PDF]

, 2018
Tämä opinnäytetyö kuvaa kirjoittajan kehittymistä B2C myyjästä B2B myyjäksi. Jotta selkeä kuva kehityskaaresta, -­kohdista ja –tavoitteista onnistutaan luomaan, käydään ensin teoriaosuudessa myynnin teoriaa läpi.
Haavisto, Perttu
core