Results 171 to 180 of about 83,545 (299)
Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation
MedComm – Oncology, Volume 5, Issue 2, June 2026.The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong +4 more
wiley +1 more source
Immunology, Volume 178, Issue 2, Page 249-260, June 2026.Schematic overview of the roles triggering receptor expressed on myeloid cells‐1 (TREM‐1) plays in monosodium urate (MSU) crystal‐induced inflammasome activation and IL‐1β secretion in gout arthritis. The present study provides novel data suggesting that blockade of TREM‐1 by LP17 attenuates MSU‐crystal‐induced inflammation through inhibition of ...
Yair Molad +2 more
wiley +1 more source
A Type VI Secretion System in Burkholderia Species cenocepacia and orbicola Triggers Distinct Macrophage Death Pathways Independent of the Pyrin Inflammasome [PDF]
, 2023 Nicole A. Loeven +5 more
openalex +1 more source
Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease
Immunology, Volume 178, Issue 2, Page 218-230, June 2026.This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley +1 more source
, 2022 Pyrin inflammasome is a guard of RhoA activity. Pyrin activation is regulated by two steps: pyrin phosphorylation enacted by RhoA effectors PKN1/2, and a second checkpoint that relies on microtubule dynamics. Mutations in the pyrin encoding MEFV gene cause an auto-inflammatory disorder termed Familial Mediterranean fever (FMF).
openaire +1 more source
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Proposed signaling pathway by which TY modulates NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis. ABSTRACT This research focuses on exploring the modulation of pyroptosis and its underlying mechanisms via the “Tianyu” formulation (TY), a traditional Chinese medicine, in human rheumatoid arthritis fibroblast‐like synovial cells (RA‐HFLS) and a collagen ...
Yueya Zhu +5 more
wiley +1 more source
Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract BACKGROUND Genetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD‐associated ABI3S209F (Abi3S212F in mouse) variant regulates cytoskeletal dynamics, but its in vivo impact on pathology is unknown. METHODS: An Abi3S212F mouse was developed and crossed with
Claire A. Butler +29 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 3, May 2026.ABSTRACT Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life‐threatening pulmonary disorders with high mortality rates, and effective treatments are currently lacking. Secoisolariciresinol diglucoside (SDG), a plant lignan derived from flaxseed, possesses anti‐inflammatory and antioxidative activities.
Yuanyuan Zhong +8 more
wiley +1 more source
Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders [PDF]
, 2018 Zheng Wang +7 more
openalex +1 more source
[Latest Findings on NOD-Like Receptor Family Pyrin Domain Containing Protein 3 Inflammasome and Bone and Articular Diseases]. [PDF]
, 2023 Jiahe Wang +3 more
openalex +1 more source