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Advances in <i>Pseudomonas aeruginosa</i>-Induced Programmed Cell Death and Potential Targeted Treatment Strategies. [PDF]

Microorganisms
Tan C, Luo Y.
europepmc   +1 more source

Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach. [PDF]

World J Gastroenterol
Dong WW, Liu T, He LX, He WT.
europepmc   +1 more source

TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases. [PDF]

J Clin Invest
Haji S, Ogawa Y.
europepmc   +1 more source

Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes

Journal of Clinical Immunology, 2023
Pyrin is a cytosolic protein encoded by the MEFV gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the activation and secretion of IL-1β and IL-18. In addition, the Pyrin inflammasome activates Gasdermin D leading to pyroptosis, a highly pro-inflammatory cell death ...
Flore Wouters, Jeroen Bogie, Andy Wullaert, Jeroen van der Hilst   +3 more
semanticscholar   +5 more sources

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CATERPILLERs, pyrin and hereditary immunological disorders

Nature Reviews Immunology, 2006
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This family has gained rapid prominence because of its demonstrated and anticipated roles in immunity, cell death and growth, and diseases.
, Hal M Hoffman
exaly   +3 more sources

Inducing Pyroptosis Via the Pyrin Inflammasome

2023
The pyrin inflammasome detects bacterial toxins and effectors that inhibit RhoA GTPases and triggers inflammatory cytokine release and a fast cell death termed pyroptosis. In addition, various endogenous molecules, drugs, synthetic molecules, or mutations can trigger pyrin inflammasome activation.
Bronnec, Pauline, Sousa, Jeremy, Henry, Thomas   +2 more
openaire   +3 more sources

Functional Assessment of Disease-Associated Pyrin Variants

2022
The pyrin inflammasome detects effectors and toxins that inhibit RhoA GTPases and triggers inflammatory cytokines release and a fast cell death termed pyroptosis. Ancient plague pandemics in the Mediterranean basin have selected in the human population pyrin variants that can trigger an autoinflammatory disease termed familial Mediterranean fever (FMF).
Chirita, Daria, Jamilloux, Yvan, Henry, Thomas, Magnotti, Flora   +3 more
openaire   +4 more sources