Results 11 to 20 of about 11,970 (271)

Monocyte Activation Test (MAT) as a possibility of replacement for the rabbit pyrogen test in hyperimmune sera

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2018
The use of a commercial kit for the monocyte-activation test (MAT) was evaluated for assessing pyrogenic contamination of hyperimmune sera . Three batches of sera, two pyrogen free and one pyrogenic, were tested.
Carla Lilian de Agostini Utescher   +3 more
doaj   +3 more sources

Routine Pyrogen Testing

open access: yesJournal of Pharmacy and Pharmacology, 1954
Summary The examination of preparations from large-scale manufacture for freedom from pyrogens is described. Typical results from the examination of 11. and 0·51. packs of water for injection, glucose-saline and solution and normal saline solution are presented.
K L Smith
openaire   +3 more sources

Pathophysiology of Fever and Application of Infrared Thermography (IRT) in the Detection of Sick Domestic Animals: Recent Advances

open access: yesAnimals, 2021
Body-temperature elevations are multifactorial in origin and classified as hyperthermia as a rise in temperature due to alterations in the thermoregulation mechanism; the body loses the ability to control or regulate body temperature.
Daniel Mota-Rojas   +10 more
doaj   +1 more source

Recombinant bacterial endotoxin testing: a proven solution

open access: yesBioTechniques, 2021
Testing of parenteral pharmaceuticals and medical devices for pyrogens (fever-inducing substances) is critical to patient safety. The original rabbit pyrogen test has largely been replaced by different bacterial endotoxin tests based on Limulus amebocyte
Brendan Tindall   +2 more
doaj   +1 more source

In-Field Implementation of a Recombinant Factor C Assay for the Detection of Lipopolysaccharide as a Biomarker of Extant Life within Glacial Environments

open access: yesBiosensors, 2012
The discovery over the past two decades of viable microbial communities within glaciers has promoted interest in the role of glaciers and ice sheets (the cryosphere) as contributors to subglacial erosion, global biodiversity, and in regulating global ...
David C. Cullen   +3 more
doaj   +1 more source

Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants

open access: yesScientific Reports, 2021
The exquisite specificity of Toll-like receptors (TLRs) to sense microbial molecular signatures is used as a powerful tool to pinpoint microbial contaminants.
Clovis H. T. Seumen   +3 more
doaj   +1 more source

Validation of moist and dry heat processes used for sterilization and depyrogenation during ampoules manufacturing [PDF]

open access: yesJournal of Advanced Biomedical and Pharmaceutical Sciences, 2020
Pyrogens are fever-producing substances, which are metabolic products of microorganisms and most potent pyrogens are the endotoxins. Depyrogenation can be defined as the elimination of all pyrogenic substances which is an important part of the ...
Ahmed Rashed   +3 more
doaj   +1 more source

Heating Evaluation of Lumbar Stand-Alone Cage Via Radio Frequency in MRI Coil and In-Vivo Pyrogen Test [PDF]

open access: yes한국정밀공학회지, 2017
Most of passive implants belong to medical device are consist of metallic and nonmetallic materials. According to the sort of components, it makes more influence into the human body.
Dong-Ki Seo, Ju-Sung Kang, Eun-Young Kim
doaj   +1 more source

Identifikasi Serovar Bakteri Leptospira sp pada Manusia dan Tikus Di Kabupaten Donggala

open access: yesJurnal Vektor Penyakit, 2022
Leptospirosis is an acute infectious disease caused by Leptospira sp bacteria and has zoonotic properties. This disease is passed on through contact with the urine of infected rat or with contaminated water and food.
Intan Tolistiawaty   +4 more
doaj   +1 more source

Development of a Monocyte Activation Test as an Alternative to the Rabbit Pyrogen Test for Mono- and Multi-Component Shigella GMMA-Based Vaccines

open access: yesMicroorganisms, 2021
Generalised modules for membrane antigens (GMMA)-based vaccines comprise the outer membrane from genetically modified Gram-negative bacteria containing membrane proteins, phospholipids and lipopolysaccharides.
Danielle Carson   +8 more
doaj   +1 more source

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