Results 1 to 10 of about 1,938 (156)

Advancing Pyrogen Testing for Vaccines with Inherent Pyrogenicity: Development of a Novel Reporter Cell-Based Monocyte Activation Test (MAT) [PDF]

Vaccines
Background/Objectives: Pyrogens, fever-inducing substances from biological or environmental sources, are recognized by Toll-like receptors (TLRs) predominantly expressed by human monocytes and represent a critical quality attribute (CQA) for ...
Sijia Yi, Jenny Xu, Liping Song, Frank Celeste, Christopher J. Wang, Melissa C. Whiteman   +5 more
doaj   +2 more sources

Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection [PDF]

mSphere
Pertussis resurged over the last decade in most countries that replaced the traditional whole-cell pertussis vaccines (wP) by the less reactogenic acellular pertussis vaccines (aP).
Karolína Škopová, Jana Holubová, Barbora Bočková, Eva Slivenecká, João Melo Santos de Barros, Ondřej Staněk, Peter Šebo   +6 more
doaj   +2 more sources

Pre-Clinical Safety and Immunogenicity Study of a Coronavirus Protein-Based Subunit Vaccine for COVID-19 [PDF]

Vaccines, 2023
Creating an effective and safe vaccine is critical to fighting the coronavirus infection successfully. Several types of COVID-19 vaccines exist, including inactivated, live attenuated, recombinant, synthetic peptide, virus-like particle-based, DNA and ...
Kamshat Shorayeva, Aziz Nakhanov, Ainur Nurpeisova, Olga Chervyakova, Kuanysh Jekebekov, Zhandos Abay, Nurika Assanzhanova, Sandugash Sadikaliyeva, Elina Kalimolda, Aibol Terebay, Sabina Moldagulova, Zharkinay Absatova, Ali Tulendibayev, Syrym Kopeyev, Gulnur Nakhanova, Aisha Issabek, Sergazy Nurabayev, Aslan Kerimbayev, Lespek Kutumbetov, Yergali Abduraimov, Markhabat Kassenov, Mukhit Orynbayev, Kunsulu Zakarya   +22 more
doaj   +2 more sources

ISO 10993 biological evaluation of novel hemostatic powder – 4SEAL® [PDF]

Biomaterials Research, 2022
Background Hemostasis plays a crucial role during every surgery allowing for a bloodless operating field. Fast and effective surgery leads to a reduced risk of postoperative complications.
Lukasz Szymanski, Kamila Golaszewska, Anna Wiatrowska, Monika Dropik, Pawel Szymanski, Bartosz Gromadka, Patrycja Krakowiak, Justyna Wierzchowska, Damian Matak   +8 more
doaj   +2 more sources

Non-pyrogenicity and biocompatibility of parylene-coated magnetic bead implants [PDF]

Frontiers in Bioengineering and Biotechnology
Clinical grade magnetic bead implants have important applications in interfacing with the human body, providing contactless mechanical attachment or wireless communication through human tissue.
Cameron R. Taylor, Joshua K. Nott, Nilmini H. Ratnasena, Joel M. Cohen, Hugh M. Herr   +4 more
doaj   +2 more sources

Biocompatibility of novel albumin-aldehyde surgical adhesive [PDF]

Scientific Reports, 2022
Many medical procedures could benefit from the use of tissue sealants which allow for reduced surgery time, limited blood loss, easier tissue handling, and fewer postoperative complications.
Lukasz Szymanski, Kamila Gołaszewska, Anna Wiatrowska, Monika Dropik, Patrycja Krakowiak, Justyna Małkowska, Damian Matak   +6 more
doaj   +2 more sources

SARS-CoV-2 mRNA vaccine candidate encoding RBD chimera of Delta and Omicron variants: immunogenic potential and validation [PDF]

Iranian Journal of Microbiology
Background and Objectives: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has presented a challenging issue for global health in the 21st century.
Shahla Shahsavandi, Sina Soleimani, Majid Tebyanian, Amir Ali Hariri, Ashraf Mohammadi, Abbas Zare Mirakabadi, Mojtaba Noofeli, Zarrin Sharifnia, Mohammad Mahdi Ranjbar   +8 more
doaj   +2 more sources

Programming Bordetella pertussis lipid A to promote adjuvanticity [PDF]

Microbial Cell Factories
Background Bordetella pertussis is the causative agent of whooping cough or pertussis. Although both acellular (aP) and whole-cell pertussis (wP) vaccines protect against disease, the wP vaccine, which is highly reactogenic, is better at preventing ...
Yasmine Fathy Mohamed, Rachel C. Fernandez   +1 more
doaj   +2 more sources

Development of a Monocyte Activation Test as an Alternative to the Rabbit Pyrogen Test for Mono- and Multi-Component Shigella GMMA-Based Vaccines

Microorganisms, 2021
Generalised modules for membrane antigens (GMMA)-based vaccines comprise the outer membrane from genetically modified Gram-negative bacteria containing membrane proteins, phospholipids and lipopolysaccharides.
Danielle Carson, Sophie Myhill, Elena Palmieri, Francesca Necchi, Sjoerd Rijpkema, Francesca Micoli, Ida Karin Nordgren, Omar Rossi, Caroline Vipond   +8 more
doaj   +1 more source

SEROLOGICAL AND BIOLOGICAL ACTIVITY OF LIPOPOLYSACCHARIDE FROM Escherichia coli L-19 [PDF]

Biotechnologia Acta, 2015
The lipopolysaccharide from Escherichia coli L-19 was isolated, chemically identified and its nontoxicity but pyrogenicity were shown. The investigations of lipopolysaccharide influence on T- and B-lymphocytes indicated that it might be used as a mitogen
L. D. Varbanets, E. L. Zdorovenko , Е. G. Garkavaya, O. S. Brovarskaya   +3 more
doaj   +1 more source