Results 11 to 20 of about 2,162 (216)

Method for Determining Pyrogenicity Using Monocytes: Prospects and Features of Application (Review)

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Determination of pyrogenic contaminants in medicines is a critical quality indicator that guarantees the preservation of life and health of patients.
E. O. Chechetova, N. P. Neugodova, O. V. Shapovalova   +2 more
doaj   +2 more sources

Endotoxins from a Pharmacopoeial Point of View [PDF]

Toxins, 2018
A pyrogen is a substance that causes fever after intravenous administration or inhalation. Gram negative endotoxins are the most important pyrogens to pharmaceutical laboratories. In the International, United States, Japanese and European Pharmacopoeias,
Elvira Franco, Verónica Garcia-Recio, Pilar Jiménez, Manuel Garrosa, Tomás Girbés, Manuel Cordoba-Diaz, Damián Cordoba-Diaz   +6 more
doaj   +2 more sources

History and current status of biological tests in Russia

Регуляторные исследования и экспертиза лекарственных средств, 2018
«Pyrogenicity» and «Abnormal Toxicity» are considered to be among most problematic pharmacopoeia monographs in the current editions of the leading world pharmacopoeias, the reasonability of which is not obvious to all experts.
M. S. Ryabtseva, T. A. Batuashvili, G. A. Sapozhnikova, N. P. Neugodova, Yu. V. Olefir, V. A. Merkulov   +5 more
doaj   +1 more source

Experimental evaluation of the possibility of determining bacterial endotoxins in typhoid Vi polysaccharide vaccines using the gel-clot test

Биопрепараты: Профилактика, диагностика, лечение, 2023
Scientific relevance. Currently, only the rabbit pyrogen test is used to test the Vianvac® typhoid Vi polysaccharide vaccine for pyrogenicity. As part of the product specification file, the gel-clot test for bacterial endotoxins (BE) will improve the ...
M. V. Abramtseva, N. S. Alekhina, E. D. Kolyshkina   +2 more
doaj   +1 more source

Structure of O-Polysaccharide and Lipid A of Pantoea Agglomerans 8488

Biomolecules, 2020
The Pantoea agglomerans 8488 lipopolysaccharide (LPS) was isolated, purified and characterized by monosaccharide and fatty acid analysis. The O-polysaccharide and lipid A components of the LPS were separated by mild acid degradation.
Tetiana V. Bulyhina, Evelina L. Zdorovenko, Ludmila D. Varbanets, Alexander S. Shashkov, Alexandra A. Kadykova, Yuriy A. Knirel, Oleh V. Lushchak   +6 more
doaj   +1 more source

A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs

Tropical Medicine and Infectious Disease, 2019
This small study reports on a non-pyrogenic response of five different Australian isolates of Coxiella burnetii (C. burnetii). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human ...
Aminul Islam, John Stenos, Gemma Vincent, Stephen Graves   +3 more
doaj   +1 more source

Рantoea agglomerans lipopolysaccharides: structure, functional and biological activity [PDF]

The Ukrainian Biochemical Journal, 2019
This review analyzed literature data, as well as our own research on lipopolysaccharides (LPS) of gram-negative bacteria, focusing mainly on Pantoea agglomerans, a member of the Enterobacteriaceae fami­ly.
L. D. Varbanets, Т. V. Bulyhina, L. А. Pasichnyk, N. V. Zhytkevich   +3 more
doaj   +1 more source

Licensed liposomal vaccines and adjuvants in the antigen delivery system

BioTechnologia, 2022
Liposomes (LSs) are promising nanoparticles with unique properties such as controlled nanosize, large surface area, increased reactivity, and ability to undergo modification.
Yuriy Krasnopolsky, Daria Pylypenko
doaj   +1 more source

Does pyrogenicity protect burning plants?

, 2019
Pyrogenic plants dominate many fire-prone ecosystems. Their prevalence suggests some advantage to their enhanced flammability, but researchers have had difficulty tying pyrogenicity to individual-level advantages.
Paine, C E Timothy, Passmore, Heather A, Harms, Kyle E, Gagnon, Paul R, Platt, William J, Myers, Jonathan A   +5 more
core   +2 more sources

Outer membrane vesicles: moving within the intricate labyrinth of assays that can predict risks of reactogenicity in humans

Human Vaccines & Immunotherapeutics, 2021
Outer membrane vesicles (OMV) are exosomes naturally released from the surface of Gram-negative bacteria. Since the ’80s, OMVs have been proposed as powerful vaccine platforms due to their intrinsic self-adjuvanticity and ability to present multiple ...
Omar Rossi, Francesco Citiulo, Francesca Mancini   +2 more
doaj   +1 more source