Results 21 to 30 of about 2,162 (216)

Nonwoven Textiles from Hyaluronan for Wound Healing Applications

Biomolecules, 2021
Nonwoven textiles are used extensively in the field of medicine, including wound healing, but these textiles are mostly from conventional nondegradable materials, e.g., cotton or synthetic polymers such as polypropylene.
Jolana Kubíčková, Tomáš Medek, Jarmila Husby, Jana Matonohová, Hana Vágnerová, Lucie Marholdová, Vladimír Velebný, Josef Chmelař   +7 more
doaj   +1 more source

Preclinical Toxicology Studies of Recombinant Human Platelet-Derived Growth Factor-BB Either Alone or in Combination with Beta-Tricalcium Phosphate and Type I Collagen [PDF]

Journal of Tissue Engineering, 2010
Human platelet-derived growth factor-BB (hPDGF-BB) is a basic polypeptide growth factor released from platelets at the injury site. It is a multifunctional molecule that regulates DNA synthesis and cell division and induces
Conan S. Young, Gino Bradica, Charlie E. Hart, Anuradha Karunanidhi, Reva M. Street, Lyndsey Schutte, Jeffrey O. Hollinger   +6 more
doaj   +1 more source

Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyrogenicity of TLR agonists [PDF]

, 2008
We present a systematic study that defines molecular profiles of adjuvanticity and pyrogenicity induced by agonists of human Toll-like receptor molecules in vitro. Using P(3)CSK(4), Lipid A and Poly I:C as model adjuvants we show that all three molecules
Marina Freudenberg, Kamgang, Richard Kenmoe, Ramos, Inês, Ghielmetti, Mascia, Elisabetta Padovan, Clemens Dahinden, Mascia Ghielmetti, Ramos, I., Padovan, Elisabetta, Rodrigues Duarte, Lurdes, Rodrigues Duarte, L., Freudenberg, M., Inês Ramos, Padovan, E., Dahinden, C., Kamgang, R., Dahinden, Clemens, Richard Kenmoe Kamgang, Lurdes Rodrigues Duarte, Ghielmetti, M., Freudenberg, Marina   +20 more
core   +1 more source

Detection of Beta-Glucan Contamination in Nanotechnology-Based Formulations

Molecules, 2020
Understanding the potential contamination of pharmaceutical products with innate immunity modulating impurities (IIMIs) is essential for establishing their safety profiles.
Barry W. Neun, Edward Cedrone, Timothy M. Potter, Rachael M. Crist, Marina A. Dobrovolskaia   +4 more
doaj   +1 more source

In vivo pyrogenicity evaluation of fungal bioproducts with prebiotic potential

Revista Información Científica, 2022
Introduction: natural products with pharmacological activity require preclinical evaluations to justify their uses scientifically. The pyrogen assay is a safety pharmacology test performed to determine the presence of endotoxins and it is a valuable ...
Yamila Lebeque-Pérez, Onel Fong-Lores, Elizabeth Rodríguez-Leblanch, Gabriel Llauradó-Maury, Manuel Jesús Serrat-Díaz   +4 more
doaj  

Preclinical Safety Evaluation of Ophthalmic Viscosurgical Devices in Rabbits and a Novel Mini-Pig Model

Ophthalmology and Therapy, 2019
Introduction To establish the preclinical safety and equivalency of ophthalmic viscosurgical devices (OVDs) comprised of bacterially sourced sodium hyaluronate (HA) to animal sourced HA using pyrogenicity and aqueous exchange models in rabbits and a ...
Ronika S. Leang, Lisa J. Kloft, Brad Gray, Arlene E. Gwon, Ling C. Huang   +4 more
doaj   +1 more source

Aplicabilidade do Teste de Ativação de Monócitos (MAT) no Brasil: importância da sua utilização como teste para detecção de pirogênios no controle da qualidade de produtos injetáveis | Applicability of the Monocyte Activation Test (MAT) in Brazil: the importance of its use as a test for the detection of pyrogens in the quality control of injectable products

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2015
O MAT (sigla do inglês Monocyte Activation Test) é considerado um potencial substituto do Teste de Pirogênios, entretanto: i. não foi avaliado para um número suficiente de produtos; ii.
Cristiane Caldeira da Silva, Mayara Cruz, João Carlos Freitas, Octavio Presgrave, Aurea Moraes, Isabella Fernandes Delgado   +5 more
doaj   +1 more source

Purity, pyrogenicity and sterility results from the ²¹¹At-BC8-B10 qualification runs.

, 2018
Purity, pyrogenicity and sterility results from the 211At-BC8-B10 qualification runs.
Ming-Kuan Chyan (2100880), Ronald L. Manger (5870378), Yawen Li (1415497), Johnnie J. Orozco (668395), Rainer Storb (5870387), Donald K. Hamlin (668399), Robert C. Emery (5870372), Eric F. Dorman (5870369), Roger Wong (786393), Douglas R. Woodle (5870375), Brenda M. Sandmaier (2100877), Margaret Nartea (5870381), Aimee L. Kenoyer (5870384), D. Scott Wilbur (668400), Oliver W. Press (498588), Damian J. Green (668403)   +15 more
core   +1 more source

Safety Profile Evaluation of an Original Mesenchymal Stromal Cell Secretome-Based Medicinal Product after Intratesticular Injection in Rabbits

Безопасность и риск фармакотерапии
INTRODUCTION. This work is a continuation of the studies of an original biological product based on the secretome of human mesenchymal stromal cells (MSCs) and intended for the restoration of spermatogenesis and fertility.
А. О. Monakova, V. Yu. Balabanyan, V. A. Vavilova, N. A. Basalova, V. S. Popov, Zh. A. Akopyan, A. Yu. Efimenko   +6 more
doaj   +1 more source

Optimization of the monocyte activation test for evaluating pyrogenicity of tick-borne encephalitis virus vaccine

, 2020
Pyrogen content is a key quality feature that must be checked in all injectable products, including vaccines. Four tests are currently available in the European Pharmacopoeia to monitor pyrogen/endotoxin presence: the rabbit pyrogen test (RPT), the ...
Valentini, Sara, Giacomini, Elena, Alleri, Liliana, Spreitzer, Ingo, Gaggioli, Andrea, Galli Stampino, Luisa, Etna, Marilena Paola, Coccia, Eliana M, von Hunolstein, Christina, Severa, Martina, Rizzo, Fabiana, Lambrigts, Denis, Ricci, Daniela, Shaid, Shahjahan   +13 more
core   +1 more source