Results 41 to 50 of about 11,970 (271)
British Journal of Clinical Pharmacology, EarlyView.With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić +4 more
wiley +1 more source
Rabbit Responses to Human Threshold Doses of A Bacterial Pyrogen
, 1954 Summary The scarcity and conflicting nature of the existing evidence on the relationship between effective doses of bacterial pyrogens in man and rabbit is pointed out.
G A Mogey, J G Dare
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar +6 more
wiley +1 more source
针刺研究, 1988 In present study we observed the effect of intermittent electric acupuncture on the discharge rate of heatsensitive neurons of preoptic-anterior hypothalamus (PO-AH)in the pyrogen treated rabbit. Twenty-one rabbits,weight between 1.8-
Yang Yonglu
doaj
Method for Determining Pyrogenicity Using Monocytes: Prospects and Features of Application (Review)
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. Determination of pyrogenic contaminants in medicines is a critical quality indicator that guarantees the preservation of life and health of patients.
E. O. Chechetova +2 more
doaj +1 more source
Response of Rabbits to Pyrogen in a Helox Environment
, 1980 1.|The effectiveness of a gas environment consisting of 80% helium and 20% oxygen (Helox) in reducing a rabbit\u27s fever due to an i.v. injection of endotoxin was found to be dependent on the amount of pyrogen injected.
Veale, W. L. +2 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura +6 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti‐seizure medication. Benzodiazepine‐containing immediate‐use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters ...
James W. Wheless +8 more
wiley +1 more source
Journal of Aerospace Technology and Management, 2016 The application of fluoropolymers in high-energy-release pyrotechnic compositions is common in the space and defense areas. Pyrotechnic compositions of magnesium/Teflon/Viton are widely used in military flares and pyrogen igniters for igniting the solid ...
Luciana de Barros +3 more
doaj +3 more sources
Immunoadjuvants enhance the febrile responses of rats to endogenous pyrogen
, 1989 The febrile responses of male Sprague-Dawley rats to a semipurified endogenous pyrogen produced from human monocytes were characterized by establishing fever dose-response curves.
S. G. Shimada, J. T. Stitt
core +1 more source